• bupropion;
  • chest pain;
  • pharmacovigilance;
  • smoking cessation

Aims  To investigate the cause of chest pain during the use of bupropion as an aid to stop smoking.

Methods  The Netherlands Pharmacovigilance Centre received 22 reports of chest pain, associated with the use of bupropion as an aid to smoking cessation. Additional information about long-term follow up was collected to analyze whether these complaints herald manifest cardiac disease.

Results  All but one patient recovered after withdrawal of bupropion. Seven patients were additionally investigated and in six of them, a cardiac cause could be excluded. During long-term follow-up, no coronary heart diseases were diagnosed.

Conclusions  These reports indicate that chest pain seems to be associated with the use of bupropion, but its origin remains unclear.