Narrow-band (TL-01) ultraviolet B phototherapy for chronic plaque psoriasis: three times or five times weekly treatment?
Article first published online: 4 JAN 2002
British Association of Dermatology
British Journal of Dermatology
Volume 138, Issue 5, pages 833–839, May 1998
How to Cite
Dawe, Wainwright, Cameron and Ferguson (1998), Narrow-band (TL-01) ultraviolet B phototherapy for chronic plaque psoriasis: three times or five times weekly treatment?. British Journal of Dermatology, 138: 833–839. doi: 10.1046/j.1365-2133.1998.02221.x
- Issue published online: 4 JAN 2002
- Article first published online: 4 JAN 2002
- Cited By
Three and five times weekly narrow-band TL-01 (311–313 nm) ultraviolet (UV) B phototherapy regimens for chronic plaque psoriasis were compared in a randomized, observer-blinded, half-body, within-patient paired study. Twenty-one patients [13 men, eight women, age range 21–68 years, skin phototypes I (two patients), II (14) and III (five)] entered the study. Sixteen reached clearance or minimal residual activity (MRA) on both sides. Of the other five, three withdrew because they did not reach clearance or MRA on the 5 × weekly side by a maximum of 30 treatments, one when he was satisfied with moderate improvement and one because of repeated failure to attend. Those who completed treatment reached clearance or MRA after a median of 35 days with 5 × weekly treatment compared with 40 days with 3 × weekly treatment (P = 0.007), but required a median of 23.5 compared with 17 UVB exposures (P = 0.001) and 94 minimal erythema dose multiples (MEDs) compared with 64 MEDs (P = 0.01). Fifteen (of 16) developed at least one episode of well-demarcated erythema during 5 × weekly treatment compared with just three of 16 treated 3 × weekly (P < 0.001). There was no significant difference between regimens in duration of remission. For this skin phototype I–III population, the more rapid clearance of psoriasis with 5 × weekly phototherapy is not, for the majority of patients, sufficient to justify the extra exposures and higher UVB dose. We no longer use 5 × weekly phototherapy for psoriasis.