Three different autoimmune bullous diseases in one family: is there a common genetic base?
Article first published online: 24 DEC 2001
British Association of Dermatology
British Journal of Dermatology
Volume 140, Issue 2, pages 322–327, February 1999
How to Cite
KIRTSCHIG, MITTAG, WOLF, GORSKI and HAPPLE (1999), Three different autoimmune bullous diseases in one family: is there a common genetic base?. British Journal of Dermatology, 140: 322–327. doi: 10.1046/j.1365-2133.1999.02674.x
- Issue published online: 24 DEC 2001
- Article first published online: 24 DEC 2001
- cicatricial pemphigoid;
- familial occurrence;
- genetic transmission;
- HLA type;
- linear IgA disease;
- pemphigus vulgaris.
We report an unusual familial occurrence of autoimmune bullous diseases. Three members of a family suffered from three different autoimmune bullous diseases: pemphigus vulgaris (PV), linear IgA disease (LAD) and cicatricial pemphigoid (CP). The HLA type was determined in five family members: all were positive for HLA-DQ5/DR6, which is reported to be associated with susceptibility to PV. The CP patient was DQ7(3) positive, which is in concordance with enhanced susceptibility to ocular CP and CP. The LAD patient was B8 and DR3 negative but positive for HLA-A1. Our study supports the hypothesis that there is a genetically transmitted susceptibility to autoimmune bullous diseases but that additional factors seem necessary actually to develop a particular disease.