Calciphylaxis in a patient without renal failure or elevated parathyroid hormone: possible aetiological role of chemotherapy


Thomas T.Provost, 7401 Osler Drive, Suite 107, Towson, Maryland 21204, USA. Tel: +1 410 321 5900; fax +1 410 821 6052.


Calciphylaxis is a rare, often fatal disease characterized clinically by progressive cutaneous necrosis and ulceration, and histologically by vascular calcification and thrombosis. It has been described in association with end-stage renal disease, after initiation of dialysis, following renal transplantation, and in patients with hyperparathyroidism. We present the first case of calciphylaxis occurring in a patient with both normal renal function and parathyroid hormone level and discuss the possible aetiological role of chemotherapy-induced functional protein C and protein S deficiency.