Calcitriol 3 µg g−1 ointment in combination with ultraviolet B phototherapy for the treatment of plaque psoriasis: results of a comparative study
Article first published online: 23 DEC 2001
British Journal of Dermatology
Volume 144, Issue 3, pages 495–499, February 2001
How to Cite
Ring, J., Kowalzick, L., Christophers, E., Schill, W.B., Schöpf, E., Ständer, M., Wolff, H.H. and Altmeyer, P. (2001), Calcitriol 3 µg g−1 ointment in combination with ultraviolet B phototherapy for the treatment of plaque psoriasis: results of a comparative study. British Journal of Dermatology, 144: 495–499. doi: 10.1046/j.1365-2133.2001.04074.x
- Issue published online: 23 DEC 2001
- Article first published online: 23 DEC 2001
- Accepted for publication 5 November 2000
- calcitriol ointment;
- plaque psoriasis;
- randomized controlled trial;
- ultraviolet B phototherapy
Background Combinations of topical treatments and ultraviolet (UV) B phototherapy for plaque psoriasis may be more beneficial than either type of treatment used alone.
Objectives To determine the efficacy of calcitriol 3 µg g−1 ointment in combination with UVB phototherapy in treating plaque psoriasis.
Methods Calcitriol ointment with UVB was compared with vehicle plus UVB in a randomized, double-blind study in 104 patients.
Results Mean global improvement scores for both groups increased over the 8-week study period; there was a statistically significant difference (P < 0·05) in favour of the calcitriol/UVB combination from week 1. At end-point, 45% of the calcitriol/UVB group showed considerable improvement or clearing of psoriasis, compared with 21% of the control group. The superiority of calcitriol plus UVB was also reflected in the global severity and Psoriasis Area and Severity Index (PASI) scores; at end-point the mean percentage decrease in PASI score was 65% for the calcitriol/UVB group and 43% for vehicle/UVB (P = 0·0014). The incidence of skin-related adverse events was low (< 12%) and similar in the two treatment groups. No clinically significant changes in blood chemistry, in particular calcium levels, occurred. The greater efficacy of combined calcitriol and phototherapy allowed a 34% decrease in total UVB exposure.
Conclusions Calcitriol 3 µg g−1 ointment and UVB phototherapy in combination provides a promising therapy for managing chronic plaque psoriasis.