Resistance to activated protein C due to factor V Leiden mutation: high prevalence in patients with post-thrombotic leg ulcers
Article first published online: 23 DEC 2001
British Journal of Dermatology
Volume 144, Issue 3, pages 546–548, February 2001
How to Cite
Gaber, Y., Siemens, H.-J. and Schmeller, W. (2001), Resistance to activated protein C due to factor V Leiden mutation: high prevalence in patients with post-thrombotic leg ulcers. British Journal of Dermatology, 144: 546–548. doi: 10.1046/j.1365-2133.2001.04081.x
- Issue published online: 23 DEC 2001
- Article first published online: 23 DEC 2001
- Accepted for publication 14 October 2000
- activated protein C resistance;
- factor V Leiden mutation;
- post-thrombotic syndrome;
- primary varicosis;
- venous leg ulcers
Background Activated protein C (APC) resistance is the most frequently diagnosed heritable thrombophilic defect predisposing to thrombosis.
Objectives To determine the prevalence of APC resistance due to factor V Leiden mutation in patients with leg ulcers.
Methods Within a 2-year-period 100 consecutive patients with leg ulcers were examined for factor V Leiden mutation.
Results APC resistance due to factor V Leiden mutation was detected in 19 of 53 patients (36%) with post-thrombotic leg ulcers and in three of 47 patients (6%) with ulcers caused by primary varicosis. In a healthy control group APC resistance due to factor V Leiden mutation was found in five of 96 (5%) volunteers.
Conclusions In view of this high prevalence of APC resistance of 36%, which has never previously been reported, patients with post-thrombotic leg ulcers should be investigated for APC resistance.