The authors have no financial or proprietary interest in any instrument or products used in this study.
Serum leptin concentration is increased in patients with Behçet's syndrome and is correlated with disease activity
Article first published online: 9 AUG 2002
British Journal of Dermatology
Volume 147, Issue 2, pages 331–336, August 2002
How to Cite
Evereklioglu, C., Inalöz, H.S., Kirtak, N., Doganay, S., Bülbül, M., Otlu, B., Özerol, E., Er, H. and Özbek, E. (2002), Serum leptin concentration is increased in patients with Behçet's syndrome and is correlated with disease activity. British Journal of Dermatology, 147: 331–336. doi: 10.1046/j.1365-2133.2002.04703.x
- Issue published online: 9 AUG 2002
- Article first published online: 9 AUG 2002
- Accepted for publication 14 October 2001
- Behçet's syndrome;
- disease activity;
SummaryBackground Behçet's syndrome is a systemic, relapsing immuno-inflammatory disease with a generalized vasculitis of the microvasculature endothelial dysfunction. Leptin, a recently discovered neuroendocrine hormone, is a metabolic peptide that appears to be involved. Serum proinflammatory cytokines upregulate leptin levels and leptin itself directly induces nitric oxide production from endothelial cells with its specific receptors.
Objectives To detect changes of serum leptin concentrations in patients with Behçet's syndrome compared with age- and sex-matched healthy volunteers by using enzyme-linked immunosorbent assay. We also investigated whether disease activity or the duration of Behçet's syndrome correlates with leptin concentration.
Methods Thirty-five consecutive patients with Behçet's syndrome (41·2 ± 8·4 years, 16 male, 19 female) and 20 age- and sex-matched healthy control subjects (40·4 ± 10·91 years, nine male, 11 female) were included in this study. The body mass index (BMI) [weight (kg) height−1 (m2)] was calculated for subjects at study enrolment. We measured serum leptin with a leptin enzyme immunoassay kit, and acute-phase reactants, including erythrocyte sedimentation rate, α1-antitrypsin, α2-macroglobulin and neutrophil count. The Mann–Whitney U-test was used for statistical analysis and P < 0·05 was considered significant. Values were expressed as mean ± SD.
Results The gender ratio, age and BMI were not substantially different among Behçet's patients and controls. The mean serum leptin concentrations in patients with Behçet's syndrome (16·8 ± 7·49 ng mL−1) were significantly (P < 0·001) higher than in healthy control volunteers (7·5 ± 2·77 ng mL−1). Active Behçet's patients had significantly (P = 0·001) higher leptin concentrations (20·5 ± 7·99 ng mL−1) when compared with patients in inactive periods (12·8 ± 4·43 ng mL−1). In addition, patients with longer disease duration (mean, 20·1 ± 5·15 years) had also significantly (P = 0·013) higher leptin concentrations (20·2 ± 8·52 ng mL−1) than those with shorter disease duration (13·4 ± 4·52 ng mL−1) (mean, 7·4 ± 3·29 years). All acute-phase reaction parameters were found to be significantly (for each, P < 0·01) increased in active disease.
Conclusions Leptinmay have a role in modulating endothelial function and may be involved in mechanisms for vessel endothelium repair, during an exacerbation as well as in chronic disease.