Professor Fuchs died while the paper was in press.
Nine-year follow-up of a case of Grzybowski type multiple keratoacanthomas and failure to demonstrate human papillomavirus
Article first published online: 4 OCT 2002
British Journal of Dermatology
Volume 147, Issue 4, pages 793–796, October 2002
How to Cite
Haas, N., Schadendorf, D., Henz, B.M. and Fuchs, P.G. (2002), Nine-year follow-up of a case of Grzybowski type multiple keratoacanthomas and failure to demonstrate human papillomavirus. British Journal of Dermatology, 147: 793–796. doi: 10.1046/j.1365-2133.2002.04925.x
- Issue published online: 4 OCT 2002
- Article first published online: 4 OCT 2002
- Accepted for publication 17 March 2002
- Grzybowski type keratoacanthoma;
- human papillomavirus;
- skin tumours
Summary We describe a patient with a 9-year history of generalized eruptive keratoacanthoma (KA) of the Grzybowski type whose multiple skin lesions showed steady progression, resulting in a sclerotic, mask-like facial expression and ectropion. Eleven tumour biopsies representing lesions of different stages and localizations (erupting and regressing KAs, biopsies from non-involved light-protected and light-exposed skin, dermatosclerosis and squamous cell carcinomas) were analysed for human papillomavirus (HPV) sequences using a polymerase chain reaction approach capable of detecting the majority of all presently known HPV genotypes. None of the biopsy specimens proved to be HPV-positive, although HPV was detected in weakly and heavily affected control specimens by the method applied. These findings suggest an HPV-independent aetiology of this rare type of multiple KA.