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The effects of ultraviolet B treatment on the expression of adhesion molecules by circulating T lymphocytes in psoriasis
Article first published online: 5 JUN 2003
DOI: 10.1046/j.1365-2133.2003.05318.x
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How to Cite
Sigmundsdottir, H., Gudjonsson, J. and Valdimarsson, H. (2003), The effects of ultraviolet B treatment on the expression of adhesion molecules by circulating T lymphocytes in psoriasis. British Journal of Dermatology, 148: 996–1000. doi: 10.1046/j.1365-2133.2003.05318.x
Publication History
- Issue published online: 5 JUN 2003
- Article first published online: 5 JUN 2003
- Accepted for publication 25 November 2002
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Keywords:
- cutaneous lymphocyte-associated antigen;
- homing molecules;
- psoriasis;
- ultraviolet B treatment
SummaryBackground T lymphocytes are believed to play a role in the pathogenesis of psoriasis; > 80% of T lymphocytes that infiltrate psoriatic lesions express the surface glycoprotein cutaneous lymphocyte-associated antigen (CLA), compared with < 20% in the blood. Exposure to ultraviolet (UV) B is an effective treatment for psoriasis.
Objectives To compare the effects of UVB treatment of psoriasis on the expression of CLA and several other surface markers expressed by circulating T lymphocytes.
Methods Peripheral blood mononuclear cells from psoriatic patients were stained for adhesion molecules and stimulated with streptococcal antigens before and once weekly during 3 weeks of UVB treatment.
Results A marked and progressive decrease was observed during the treatment in expression of the CLA and the very late antigen-4α by T cells; this decrease correlated closely with clinical improvement (Psoriasis Area and Severity Index). T-cell expression of intercellular adhesion molecule-1 was not significantly affected during the treatment and no change was observed in the activation markers CD25 and CD69 or lymphocyte proliferation after stimulation with streptococcal antigens or superantigens.
Conclusions UVB treatment is associated with a marked reduction in the expression of skin-homing molecules by circulating T cells. This may be relevant to the therapeutic effect of UVB in psoriasis.