Sustained remission of severe resistant autoimmune neutropenia with Campath-1H

Authors


Dr Judith C. W. Marsh Division of Haematology, Department of Cellular and Molecular Sciences, St George’s Hospital Medical School, Cranmer Terrace, London SW17 0RE.

Abstract

We report the course of a patient with severe autoimmune neutropenia in whom only transient responses occurred with corticosteroids, antilymphocyte globulin and granulocyte-colony stimulating factor, and who was resistant to treatment with azathioprine, cyclosporin and intravenous immunoglobulin. A 10 d course of intravenous Campath-1H monoclonal resulted in a sustained haematological response. The long-lasting effect of Campath-1H may be due to its remarkable ability to induce a profound and prolonged peripheral blood T lymphopenia.

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