• 1
    Cohen Solal, K., Villeval, J.L., Titeux, M., Lok, S., Vainchenker, W., Wendling, F. (1996) Constitutive expression of Mpl ligand transcripts during thrombocytopenia or thrombocytosis. Blood, 88, 2578 2584.
  • 2
    Emmons, R.V.B., Reid, D.M., Cohen, R.L., Meng, G., Young, N.S., Dunbar, C.E., Shulman, N.R. (1996) Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction. Blood, 87, 4068 4071.
  • 3
    Frickhofen, N., Kaltwasser, J.P., Schrezenmeier, H., Raghavachar, A., Vogt, H.G., Herrmann, F., Freund, M., Meusers, P., Salama, A., Heimpel, H. (1991) Treatment of aplastic anemia with antilymphocyte globulin and methylprednisolone with or without cyclosporine. New England Journal of Medicine, 324, 1297 1304.
  • 4
    Hirayama, Y., Kohgo, Y., Matsunaga, T., Ohi, S., Sakamaki, S., Niitsu, Y. (1993) Cytokine mRNA expression of bone marrow stromal cells from patients with aplastic anaemia and myelodysplastic syndrome. British Journal of Haematology, 85, 676 683.
  • 5
    Ichikawa, N., Ishida, F., Shimodaira, S., Tahara, T., Kato, T., Kitano, K. (1996) Regulation of serum thrombopoietin levels by platelets and megakaryocytes in patients with aplastic anaemia and idiopathic thrombocytopenic purpura. Thrombosis and Haemostasis, 76, 156 160.
  • 6
    Kaushansky, K. (1995) Thrombopoietin: the primary regulator of platelet production. Blood, 86, 419 431.
  • 7
    Kern, P., Heimpel, H., Heit, W., Kubanek, B. (1977) Granulocytic progenitor cells in aplastic anaemia. British Journal of Haematology, 65, 613 623.
  • 8
    Kojima, S., Fukuda, M., Miyajima, Y., Matsuyama, T., Horibe, K. (1991) Treatment of aplastic anemia in children with recombinant human granulocyte colony-stimulating factor. Blood, 77, 937 941.
  • 9
    Kojima, S. & Matsuyama, T. (1994) Stimulation of granulopoiesis by high-dose recombinant human granulocyte colony-stimulating factor in children with aplastic anemia and very severe neutropenia. Blood, 83, 1474 1478.
  • 10
    Kojima, S., Matsuyama, T., Kodera, Y. (1992) Hematopoietic growth factors released by marrow stromal cells from patients with aplastic anemia. Blood, 79, 2256 2261.
  • 11
    Kojima, S., Matsuyama, T., Kodera, Y., Nishihira, H., Ueda, K., Shimbo, T., Nakahata, T. (1996) Measurement of endogenous plasma granulocyte colony-stimulating factor in patients with aquired aplastic anemia by a sensitive chemiluminescent immunoassay. Blood, 87, 1303 1308.
  • 12
    Kojima, S., Matsuyama, T., Kodera, Y., Tahara, T., Kato, T. (1997) Measurement of endogenous plasma thrombopoietin in patients with acquired aplastic anaemia by a sensitive enzyme-linked immunosorbent assay. British Journal of Haematology, 97, 538 543.
  • 13
    Kosugi, S., Kurata, Y., Tomiyama, Y., Tahara, T., Kato, T., Tadokoro, S., Shiraga, M., Honda, S., Kanakura, Y., Matsuzawa, Y. (1996) Circulating thrombopoietin level in chronic immune thrombocytopenic purpura. British Journal of Haematology, 93, 704 706.
  • 14
    Kunishima, S., Tahara, T., Kato, T., Kobayashi, S., Saito, H., Naoe, T. (1996) Serum thrombopoietin and plasma glycocalicin concentrations as useful diagnostic markers in thrombocytopenic disorders. European Journal of Haematology, 57, 68 71.
  • 15
    Kuter, D.J. & Rosenberg, R.D. (1995) The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit. Blood, 85, 2720 2730.
  • 16
    Marsh, J.C., Gibson, F.M., Prue, R.L., Bowen, A., Dunn, V.T., Hornkohl, A.C., Nichol, J.L., Gordon Smith, E.C. (1996) Serum thrombopoietin levels in patients with aplastic anaemia. British Journal of Haematology, 95, 605 610.
  • 17
    McCarty, J.M., Sprugel, K.H., Fox, N.E., Sabath, D.E., Kaushansky, K. (1995) Murine thrombopoietin mRNA levels are modulated by platelet count. Blood, 86, 3668 3675.
  • 18
    Nimer, S.D., Leung, D.H., Wolin, M.J., Golde, D.W. (1994) Serum stem cell factor levels in patients with aplastic anemia. International Journal of Hematology, 60, 185 189.
  • 19
    Nissen, C., Moser, Y., Dalle Carbonare, V., Gratwohl, A., Speck, B. (1989) Complete recovery of marrow function after treatment with anti-lymphocyte globulin is associated with high, whereas early failure and development of paroxysmal nocturnal haemoglobinuria are associated with low endogenous G-CSA-release. British Journal of Haematology, 72, 573 577.
  • 20
    Nissen, C., Moser, Y., Speck, B., Gratwohl, A., Weis, J. (1985) Stimulatory serum factors in aplastic anaemia. II. Prognostic significance for patients treated with high dose immunosuppression. British Journal of Haematology, 61, 499 512.
  • 21
    Noe, G., Riedel, W., Kubanek, B., Rich, I.N. (1992) A sensitive sandwich ELISA for measuring erythropoietin in human serum. British Journal of Haematology, 80, 285 292.
  • 22
    Raghavachar, A., Ganser, A., Freund, M., Heimpel, H., Herrmann, F., Schrezenmeier, H. (1996) Long-term interleukin-3 and intensive immunosuppression in the treatment of aplastic anemia. Cytokines and Molecular Therapy, 2, 215 223.
  • 23
    Schrezenmeier, H., Hertenstein, B., Wagner, B., Raghavachar, A., Heimpel, H. (1995) A pathogenetic link between aplastic anemia and paroxysmal nocturnal hemoglobinuria is suggested by a high frequency of aplastic anemia patients with a deficiency of phosphatidylinositol glycan anchored proteins. Experimental Hematology, 23, 81 87.
  • 24
    Schrezenmeier, H., Jenal, G., Herrmann, F., Heimpel, H., Raghavachar, A., Jenal, M. (1996) Quantitative analysis of cobblestone area forming cells in bone marrow of patients with aplastic anemia by limiting dilution assay. Blood, 88, 4474 4480.
  • 25
    Schrezenmeier, H., Noe, G., Raghavachar, A., Rich, I.N., Heimpel, H., Kubanek, B. (1994) Serum erythropoietin and serum transferrin receptor levels in aplastic anaemia. British Journal of Haematology, 88, 286 294.
  • 26
    Schrezenmeier, H., Raghavachar, A., Heimpel, H. (1993) Granulocyte-macrophage colony-stimulating factor in the sera of patients with aplastic anemia. The Clinical Investigator, 71, 102 108.
  • 27
    Stark, R., Andre, C., Thierry, D., Cherel, M., Galibert, F., Gluckman, E. (1993) The expression of cytokine and cytokine receptor genes in long-term bone marrow culture in congenital and acquired bone marrow hypoplasias. British Journal of Haematology, 83, 560 566.
  • 28
    Stoffel, R., Wiestner, A., Skoda, R.C. (1996) Thrombopoietin in thrombocytopenic mice: evidence against regulation at the mRNA level and for a direct regulatory role of platelets. Blood, 87, 567 573.
  • 29
    Sungaran, R., Markovic, B., Chong, B.H. (1997) Localization and regulation of thrombopoietin mRNa expression in human kidney, liver, bone marrow, and spleen using in situ hybridization. Blood, 89, 101 107.
  • 30
    Tahara, T., Usuki, K., Sato, H., Ohashi, H., Morita, H., Tsumura, H., Matsumoto, A., Miyazaki, H., Urabe, A., Kato, T. (1996) A sensitive sandwich ELISA for measuring thrombopoietin in human serum: serum thrombopoietin levels in healthy volunteers and in patients with haemopoietic disorders. British Journal of Haematology, 93, 783 788.
  • 31
    Takahashi, M., Nikkuni, K., Moriyama, Y., Shibata, A. (1991) GM-CSF-mediated impairment of liver to synthesize albumin, cholinesterase, and cholesterol. American Journal of Hematology, 36, 213 214.
  • 32
    Usuki, K., Tahara, T., Iki, S., Endo, M., Osawa, M., Kitazume, K., Kato, T., Miyazaki, H., Urabe, A. (1996) Serum thrombopoietin level in various hematological diseases. Stem Cells, 14, 558 565.
  • 33
    Watari, K., Asano, S., Shirafuji, N., Kodo, H., Ozawa, K., Takaku, F., Kamachi, S. (1989) Serum granulocyte colony-stimulating factor levels in healthy volunteers and patients with various disorders as estimated by enzyme immunoassay. Blood, 73, 117 122.
  • 34
    Wodnar Filipowicz, A., Lyman, S.D., Chklovskaia, E., Jansen, W., Gratwohl, A., Nissen, C. (1996) Flt3 ligand level reflects hematopoietic progenitor cell function in multilineage bone marrow failure. (Abstract). Experimental Hematology, 24, 1063.
  • 35
    Wodnar Filipowicz, A., Yancik, S., Moser, Y., Dalle Carbonare, V., Gratwohl, A., Tichelli, A., Speck, B., Nissen, C. (1993) Levels of soluble stem cell factor in serum of patients with aplastic anemia. Blood, 81, 3259 3264.
  • 36
    Yang, H.H., Bruno, E., Hoffman, R. (1986) Studies of human megakaryocytopoiesis using an anti-megakaryocyte colony- stimulating factor antiserum. Journal of Clinical Investigation, 77, 1873 1880.
  • 37
    Young, N.S. (1995) Aplastic anaemia. Lancet, 346, 228 232.