• 1
    Abboud, S.L. (1993) A bone marrow stromal cell line is a source and target for platelet-derived growth factor. Blood, 81, 2547 2553.
  • 2
    Bellón, T., Corbí, A., Lastres, P., Calés, C., Cebrián, M., Vera, S., Chiefetz, S., Letarte, M., Bernabeu, C. (1993) Identification and expression of two forms of the human transforming growth factor-β1-binding protein endoglin with distinct cytoplasmic regions. European Journal of Immunology, 23, 2340 2345.
  • 3
    Bühring, H.J., Müller, C.A., Letarte, M., Gougos, A., Saalmüller, A., van Agthoven, A.J., Busch, F.W. (1991) Endoglin is expressed on a subpopulation of immature erythroid cells of normal human bone marrow. Leukemia, 5, 841 847.
  • 4
    Cheifetz, S., Bellón, T., Calés, C., Vera, S., Bernabeu, C., Massagué, J., Letarte, M. (1992) Endoglin is a component of the transforming growth factor-β receptor system in human endothelial cells. Journal of Biological Chemistry, 267, 19027–19030.
  • 5
    Cheifetz, S. & Massagué, J. (1991) Isoform-specific transforming growth factor-β binding proteins with membrane attachments sensitive to phosphatidylinositol-specific phospholipase C. Journal of Biological Chemistry, 266, 20767–20772.
  • 6
    Dejana, E., Colella, S., Languino, L.R., Balconi, G., Corbascio, C., Marchisio, P.C. (1987) Fibrinogen induces adhesion, spreading and microfilament organization of human endothelial cells in vitro. Journal of Cell Biology, 104, 1403 1411.
  • 7
    Deryugina, E.I. & Müller-Sieburg, C.E. (1993) Stromal cells in long-term cultures: keys to the elucidation of hematopoietic development? Critical Reviews in Immunology, 13, 115 150.
  • 8
    Dorshkind, K. (1990) Regulation of haemopoiesis by bone marrow stromal cells and their products. Annual Review of Immunology, 8, 111 137.
  • 9
    Dubois, C.M., Ruscetti, F.W., Palaszynski, E.W., Falk, L.A., Oppenheim, J.J., Keller, J.R. (1990) Transforming growth factor-β is a potent inhibitor of interleukin 1 (IL-1) receptor expression: proposed mechanism of inhibition of IL-1 action. Journal of Experimental Medicine, 172, 737 744.
  • 10
    Dubois, C.M., Ruscetti, F.W., Stankova, J., Keller, J.R. (1994) Transforming growth factor-β regulates c-kit message stabolity and cell-surface protein expression in hematopoietic progenitors. Blood, 83, 3138 3145.
  • 11
    Eaves, C.J., Cashman, J.D., Kay, R.J., Dougherty, G.J., Otsuka, T., Gaboury, L.A., Hogge, D.E., Lansdorp, P.M., Eaves, A.C., Humphries, R.K. (1991) Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures. II. Analysis of positive and negative regulators produced by stromal cells within the adherent layer. Blood, 78, 110 117.
  • 12
    Fava, R.A., Casey, T.T., Wilcox, J., Pelton, R.W., Moses, H.L., Nanney, L.B. (1990) Synthesis of transforming growth factor-β1 by megakaryocytes and its localization to megakaryocyte and platelet α-granules. Blood, 76, 1946 1955.
  • 13
    Friedrich, C., Zausch, E., Sugrue, S.P., Gutiérrez-Ramos, J.C. (1996) Hematopoietic supportive functions of mouse bone marrow and fetal liver microenvironment: dissection of granulocyte, B-lymphocyte, and hematopoietic progenitor support at the stroma cell clone level. Blood, 87, 4596 4606.
  • 14
    Gimble, J.M., Hudson, J., Henthorn, J., Hua, X.X., Burstein, S.A. (1991) Regulation of interleukin 6 expression in murine bone marrow stromal cells. Experimental Hematology, 19, 1055 1060.
  • 15
    Gimble, J.M., Pietrangeli, C., Henley, A., Dorheim, M.A., Silver, J., Namen, A., Takeichi, M., Goridis, C., Kincade, P.W. (1989) Characterization of murine bone marrow and spleen-derived stromal cells: analysis of leucocyte marker and growth factor mRNA transcript levels. Blood, 74, 303 311.
  • 16
    Gougos, A. & Letarte, M. (1988) Identification of a human endothelial cell antigen with monoclonal antibody 44G4 produced against a pre-B leukemic cell line. Journal of Immunology, 141, 1925 1933.
  • 17
    Gougos, A. & Letarte, M. (1990) Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells. Journal of Biological Chemistry, 265, 8361–8364.
  • 18
    Heinrich, M.C., Dooley, D.C., Keeple, W.W. (1995) Tranforming growth factor-β1 inhibits expression of the gene products for steel factor and its receptor (c-kit) . Blood, 85, 1769 1780.
  • 19
    Hemler, M.E., Sánchez-Madrid, F., Flotte, T.J., Krensky, A.M., Burakoff, S.J., Bhan, A.K., Springer, T.A., Strominger, J.L. (1984) Glycoproteins of 210,000 and 130,000 M.W. on activated T cells: cell distribution and antigenic relation to components on resting cells and T cell lines. Journal of Immunology, 132, 3011 3018.
  • 20
    Hino, M., Tojo, A., Miyazono, K., Miura, Y., Urabe, A., Takaku, F. (1988) Effects of type β transforming growth factors on haematopoietic progenitor cells. British Journal of Haematology, 70, 143 147.
  • 21
    Hurley, R.W., McCarthy, J.B., Verfaillie, C.M. (1995) Direct adhesion to bone marrow stroma via fibronectin receptors inhibits hematopoietic progenitor proliferation. Journal of Clinical Investigation, 96, 511 519.
  • 22
    Ignotz, R.A. & Massagué, J. (1986) Transforming growth factor-β stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. Journal of Biological Chemistry, 261, 4337 4345.
  • 23
    Jacobsen, E.S.W., Ruscetti, F.W., Roberts, A.B., Keller, J.R. (1993) TGF-β is a bidirectional modulator of cytokine receptor expression on murine bone marrow cells. Journal of Immunology, 151, 4534 4544.
  • 24
    Jacobsen, F.W., Stokke, T., Jacobsen, S.E.W. (1995) Transforming growth factor-β potently inhibits the viability-promoting activity of stem cell factor and other cytokinesis and induces apoptosis of primitive murine hematopoietic progenitor cells. Blood, 86, 2957 2966.
  • 25
    Keller, J.R., Jacobsen, S.E., Sill, K.T., Ellingsworth, L.R., Ruscetti, F.W. (1991) Stimulation of granulopoiesis by transforming growth factor β: synergy with granulocyte/macrophage-colony stimulating factor. Proceedings of the National Academy of Sciences of the United States of America, 88, 7190 7194.
  • 26
    Keller, J.R., Mantel, C., Sing, G.K., Ellingsworth, L.R., Ruscetti, S.K., Ruscetti, F.W. (1988) Transforming growth factor β1 selectively regulates early murine hematopoietic progenitors and inhibits the growth of IL-3-dependent cell lines. Journal of Experimental Medicine, 168, 737 750.
  • 27
    Kingsley, D.M. (1994) The TGF-β superfamily: new members, new receptors, and new genetic tests of function in different organisms. Trends in Genetics, 10, 16 21.
  • 28
    Lastres, P., Bellón, T., Cabañas, C., Sánchez-Madrid, F., Acevedo, A., Gougos, A., Letarte, M., Bernabeu, C. (1992) Regulated expression on human macrophages of endoglin, an Arg-Gly-Asp-containing surface antigen. European Journal of Immunology, 22, 393 397.
  • 29
    Lastres, P., Letamendía, A., Zhang, H., Rius, C., Almendro, N., Raab, U., López, L.A., Langa, C., Fabra, A., Letarte, M., Bernabeu, C. (1996) Endoglin modulates cellular responses to TGF-β1. Journal of Cell Biology, 133, 1109 1121.
  • 30
    Lemke, H., Hammerling, G.J., Hofmann, C., Rajewsky, K. (1978) Hybrid cell lines secreting monoclonal antibody specific for major histocompatibility antigens of the mouse. Nature, 271, 249 251.
  • 31
    Lundell, B.I., McCarthy, J.B., Kovach, N.L., Verfaillie, C.M. (1996) Activation-dependent α5β1 integrin-mediated adhesion to fibronectin decreases proliferation of chronic myelogenous leukemia progenitors and K562 cells. Blood, 87, 2450 2458.
  • 32
    Massagué, J. (1987) Identification of receptors for type-β transforming growth factor. Methods in Enzymology, 146, 174 195.
  • 33
    Massagué, J. (1996) TGF-β signaling: receptors, transducers, and mad proteins. Cell, 85, 947 950.
  • 34
    Massagué, J., Attisano, L., Wrana, J.L. (1994) The TGF-β family and its composite receptors. Trends in Cellular Biology, 4, 172 178.
  • 35
    Massagué, J. & Polyak, K. (1995) Mammalian antiproliferative signals and their targets. Current Opinion in Genetics and Development, 5, 91 96.
  • 36
    McAllister, K.A., Grogg, K.M., Johnson, D.W., Gallione, C.J., Baldwin, M.A., Jackson, C.E., Helmbold, E.A., Markel, D.S., McKinnon, W.C., Murrell, J., McCorminck, M.K., Pericak-Vance, M.A., Heutink, P., Oostra, B.A., Haitjema, T., Westerman, C.J.J., Porteus, M.E., Guttmacher, A.E., Letarte, M., Marchuk, D.A. (1994) Endoglin, a TGF-β-binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1. Nature Genetics, 8, 345 351.
  • 37
    Moore, K.A., Pytowski, B., Witte, L., Hicklin, D., Lemisschka, I.R. (1997) Hematopoietic activity of a stromal cell transmembrane protein containing epidermal growth factor-like repeat motifs. Proceedings of the National Academy of Sciences of the United States of America, 94, 4011 4016.
  • 38
    Ohta, M., Greenberger, J.S., Anklesaria, P., Bassols, A., Massagué, J. (1987) Two forms of transforming growth factor-β distinguished by multipotential haematopoietic progenitor cells. Nature, 329, 539 541.
  • 39
    Ottmann, O.G. & Pelus, L.M. (1988) Differential proliferative effects of transforming growth factor-β on human hematopoietic progenitor cells. Journal of Immunology, 140, 2661 2665.
  • 40
    Robledo, M.M., Hidalgo, A., Lastres, P., Arroyo, A.G., Bernabeu, C., Sánchez-Madrid, F., Teixidó, J. (1996) Characterization of TGF-β1-binding proteins in human bone marrow stromal cells. British Journal of Haematology, 93, 507 514.
  • 41
    Robledo, M.M., Sanz-Rodríguez, F., Hidalgo, A., Teixidó, J. (1998) Differential use of VLA-4 and VLA-5 integrins by hematopoietic precursors and myeloma cells to adhere to TGF-β1-treated bone marrow stroma. Journal of Biological Chemistry, In press.
  • 42
    Rokhlin, O.W., Cohen, M.B., Kubagawa, H., Letarte, M., Cooper, M.D. (1995) Differential expression of endoglin on fetal and adult hematopoietic cells in human bone marrow. Journal of Immunology, 154, 4456 4465.
  • 43
    Roldán, E., García-Pardo, A., Brieva, J.A. (1992) VLA-4–fibronectin interaction is required for the terminal differentiation of human bone marrow cells capable of spontaneous and high rate immunoglobin secretion. Journal of Experimental Medicine, 175, 1739 1747.
  • 44
    Sansilvestri, P., Cardoso, A.A., Batard, P., Panterne, B., Hatzfeld, A., Lim, B., Lévesque, J.-P., Monier, M.-N., Hatzfeld, J. (1995) Early CD34high cells can be separated into KIThigh cells in which transforming growth factor-β (TGF-β) down-modulates c-kit and KIT low cells in which anti-TGF-β up-modulates c-kit. Blood, 86, 1729 1735.
  • 45
    Simmons, P.J. & Torok-Storb, B. (1991) Identification of stromal cell precursors in human bone marrow by a novel monoclonal antibody, STRO-1. Blood, 78, 55 62.
  • 46
    Tang, N., Nuccie, B.L., Ritterman, I., Liesveld, J.L., Abboud, C.N., Ryan, D.H. (1997) TGF-β down-regulates stromal IL-7 secretion and inhibits proliferation of human B cell precursors. Journal of Immunology, 159, 117 125.
  • 47
    Teixidó, J., Hemler, M.E., Greenberger, J.S., Anklesaria, P. (1992) Role of β1 and β2 integrins in the adhesion of human CD34hi stem cells to bone marrow stroma. Journal of Clinical Investigation, 90, 358 367.
  • 48
    Urashima, M., Ogata, A., Chuhan, D., Hatziyanni, M., Vidriales, M.B., Dedera, D.A., Schlossman, R.L., Anderson, K.C. (1996) Transforming growth factor-β1: differential effects on multiple myeloma versus normal B cells. Blood, 87, 1928 1938.
  • 49
    Wahl, S.M., Hunt, D.E., Wakefield, L.M., McCartney-Francis, N., Wahl, L.M., Roberts, A.B., Sporn, M.B. (1987) Transforming growth factor type β induces monocyte chemotaxis and growth factor production. Proceedings of the National Academy of Sciences of the United States of America, 84, 5788 5792.
  • 50
    Wrana, J.L., Attisano, L., Wieser, R., Ventura, F., Massagué, J. (1994) Mechanism of activation of the TGF-β receptor. Nature, 370, 341 343.
  • 51
    Yamakage, A., Kikuchi, K., Smith, E.A., LeRoy, C.L., Trojanowska, M. (1992) Selective upregulation of platelet-derived growth factor-β receptors by transforming growth factor β in scleroderma fibroblasts. Journal of Experimental Medicine, 175, 1227 1234.
  • 52
    Yamashita, H., Ichijo, H., Grimsby, S., Morén, A., ten Dijke, P., Miyazono, K. (1994) Endoglin forms a heteromeric complex with the signaling receptors for transforming growth factor-β. Journal of Biological Chemistry, 269, 1995 2001.
  • 53
    Zhang, H., Shaw, A.R.E., Mak, A., Letarte, M. (1996) Endoglin is a component of the transforming growth factor (TGF)-β receptor complex of human pre-B leukemic cells. Journal of Immunology, 156, 565 573.