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Keywords:

  • thrombosis;
  • methylenetetrahydrofolate reductase;
  • factor V Leiden;
  • prothrombin

Odds ratios for the MTHFRC677T variant were determined in a large case–control study of 558 unselected patients with venous thromboembolism and 500 control subjects. The odds ratios for MTHFRC677T heterozygosity and homozygosity were 1.07 (95%CI 0.84–1.36) and 0.71 (95%CI 0.48–1.03). In patients with the factor V Leiden or the F2G20210A mutations there was no apparent increase in risk of venous thromboembolism due to the MTHFRC677T polymorphism.

Thrombophilia testing should not include genotyping for the MTHFRC677T polymorphism.