• 1
    Araki, A. & Sako, Y. (1987) Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection. Journal of Chromatography, 422, 4352.
  • 2
    Bertina, R.M., Koeleman, B.P.C., Koster, T., Rosendaal, F.R., Dirven, R.J., De Ronde, H., Van Der Velden, P.A. & Reitsma, P.H. (1994) Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature, 369, 6467.
  • 3
    D'Angelo, A. & Selhub, J. (1997) Homocysteine and thrombotic disease. Blood, 90, 111.
  • 4
    Den Heijer, M., Blom, H.J., Gerrits, W.B.J., Rosendaal, F.R., Haak, H.L., Wijermans, P.W. & Bos, G.M.J. (1995) Is hyperhomocysteinaemia a risk factor for recurrent venous thrombosis? Lancet, 345, 882885.
  • 5
    Den Heijer, M., Koster, T., Blom, H.J., Bos, G.M.J., Briet, E., Reitsma, P.H., Vanderbroucke, J.P. & Rosendaal, F.R. (1996) Hyperhomocysteinemia as a risk factor for deep-vein thrombosis. New England Journal of Medicine, 334, 759762.
  • 6
    Den Heijer, M., Rosendaal, F.R., Blom, H.J., Gerrits, W.B.J. & Bos, G.M.J. (1998) Hyperhomocysteinemia and venous thrombosis: a meta-analysis. Thrombosis and Hemostasis, 80, 874877.
  • 7
    De Stefano, V., Chiusolo, P., Paciaroni, K., Casorelli, I., Rossi, E., Molinari, M., Servidei, S., Tonali, P.A. & Leone, G. (1998a) Prothrombin G20210A mutant genotype is a risk factor for cerebrovascular ischemic disease in young patients. Blood, 91, 35623565.
  • 8
    De Stefano, V., Chiusolo, P., Paciaroni, K. & Leone, G. (1998b) Epidemiology of factor V Leiden: clinical implications. Seminars in Thrombosis and Haemostasis, 24, 367379.
  • 9
    De Stefano, V., Finazzi, G. & Mannucci, P.M. (1996) Inherited thrombophilia: pathogenesis, clinical syndromes, and management. Blood, 87, 35313544.
  • 10
    Falcon, C.R., Cattaneo, M., Panzeri, D., Martinelli, I. & Mannucci, P.M. (1994) High prevalence of hyperhomocyst(e)inemia in patients with juvenile venous thrombosis. Arteriosclerosis and Thrombosis, 14, 10801083.
  • 11
    Fermo, I., Vigano’ D'Angelo, S., Paroni, R., Mazzola, G., Calori, G. & D'Angelo, A. (1995) Prevalence of moderate hyperhomocysteinemia in patients with early-onset venous and arterial occlusive disease. Annals of Internal Medicine, 123, 747753.
  • 12
    Poort, S.R., Rosendaal, F.R., Reitsma, P.H. & Bertina, R.M. (1996) A common genetic variation in the 3′ untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood, 88, 36983703.
  • 13
    Ridker, P.M., Hennekens, C.H., Selhub, J., Miletich, J.P., Malinow, M.R. & Stampfer, M.J. (1997) Interrelation of hyperhomocyst(e)inemia, factor V Leiden, and risk of future venous thromboembolism. Circulation, 95, 17771782.
  • 14
    Simioni, P., Prandoni, P., Burlina, A., Tormene, D., Sardella, C., Ferrari, V., Benedetti, L. & Girolami, A. (1996) Hyperhomocysteinemia and deep-vein thrombosis: a case–control study. Thrombosis and Hemostasis, 76, 883886.