• Please log in or register to access this feature.
You have full text access to this OnlineOpen article

Increased serum levels of vascular endothelial growth factor predict risk of progression in early B-cell chronic lymphocytic leukaemia

  1. Stefano Molica1,
  2. Gaetano Vitelli2,
  3. Domenico Levato1,
  4. Giuseppe Maria Gandolfo2,
  5. Vincenzo Liso3

Article first published online: 24 DEC 2001

DOI: 10.1046/j.1365-2141.1999.01752.x

Issue

British Journal of Haematology

British Journal of Haematology

Volume 107, Issue 3, pages 605–610, December 1999

Additional Information

How to Cite

Molica, S., Vitelli, G., Levato, D., Gandolfo, G. M. and Liso, V. (1999), Increased serum levels of vascular endothelial growth factor predict risk of progression in early B-cell chronic lymphocytic leukaemia. British Journal of Haematology, 107: 605–610. doi: 10.1046/j.1365-2141.1999.01752.x

Author Information

  1. 1

    Divisione Ematologia e Oncologia Clinica, Azienda Ospedaliera ‘Pugliese-Ciaccio’, Catanzaro

  2. 2

    Servizio Patologia Clinica, IRCCS, Istituto Regina Elena, Roma

  3. 3

    Cattedra Ematologia, Università degli Studi, Bari, Italy

* Stefano Molica Department of Haematology/Oncology, Azienda Ospedaliera ‘Pugliese-Ciaccio’, Viale Pio X, 88100 Catanzaro, Italy. e-mail: molica@voyager.it

Publication History

  1. Issue published online: 24 DEC 2001
  2. Article first published online: 24 DEC 2001

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (152K)

References

  • 1
    Aguyao, A., Kantarjian, H., Manshouri, T., Gidel, C., Barlogie, B., Koller, C., O'Brien, S., Albitar, M., Keating, M. (1998) Low levels of vascular endothelial growth factor (VEGF) in cells of patients with chronic lymphoid leukemia (CLL) correlate with survival, particularly in patients with low beta-2 microglobulin levels. Blood, 92, (Suppl. 1), 226a.
  • 2
    Banks, R.E., Forbes, M.A., Kinsey, S.E., Stanley, A., Ingham, E., Walters, C., Selby, P.J. (1998) Release of the angiogenic cytokine vascular endothelial growth factor (VEGF) from platelets: significance for VEGF measurements and cancer biology. British Journal of Cancer, 77, 956 964.
  • 3
    Bellamy, W.T., Richter, L., Frutiger, Y., Grogan, T.M. (1999) Expression of vascular endothelial growth factor and its receptors in hematopoietic malignancies. Cancer Research, 59, 728 733.
  • 4
    Berse, B., Brown, L.F., Van De Water, L., Dvokar, H.F., Senger, D.R. (1992) Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors. Molecular and Cellular Biology, 3, 211 219.
  • 5
    Bertolini, F., Paolucci, M., Peccatori, F., Cinieri, S., Agazzi, A., Ferrucci, P.F., Cocorocchio, E., Goldhirsch, A., Martinelli, G. (1999) Angiogenic growth factors and endostatin in non-Hodgkin's lymphoma. British Journal of Haematology, 106, 504 509.
  • 6
    Binet, J.L., Auquier, A., Dighiero, G., Chastang, C., Piguet, H., Goasguen, J., Vaugier, G., Potron, G., Colona, P., Oberling, F., Thomas, M., Tchernia, G., Jacquillat, C., Boivin, P., Lesty, C., Duault, M.T., Monconduit, M., Belabbes, S., Gremy, F. (1981) A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis. Cancer, 48, 198 212.
  • 7
    Cheson, B.D., Bennett, J.M., Grever, M., Kay, N., Keating, M.J., O'Brien, S., Rai, K.R. (1996) National Institute-sponsored working group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood, 87, 4990 4997.
  • 8
    Cohen, T., Nahari, D., Cerem, L.W., Neufeld, G., Levi, B.Z. (1996) Interleukin 6 induces the expression of vascular endothelial growth factor. Journal of Biological Chemistry, 271, 736 743.
  • 9
    Dighiero, G., Maloum, K., Desablens, B., Cazin, B., Navarro, M., Leblay, R., Leporrier, M., Jaubert, J., Lepeu, G., Dreyfus, B., Binet, J.L., Travade, P. (1998) Chlorambucil in indolent chronic lymphocytic leukemia. New England Journal of Medicine, 338, 1506 1514.
  • 10
    Dirix, L.Y., Vermeulen, P.B., Hubens, G., Benoy, I., Martin, M., De Pooter, C., Van Oosterom, A.T. (1996) Serum basic fibroblast growth factor and vascular endothelial growth factor and tumour growth kinetics in advanced colorectal cancer. Annals of Oncology, 7, 843 848.
  • 11
    Dunst, J., Pigorsch, S., Hansgen, G., Hintner, I., Lautenschlager, C., Becker, A. (1999) Low hemoglobin is associated with increased levels of vascular endothelial growth factor (VEGF) in cancer patients. Does anemia stimulate angiogenesis? Strahlenther Onkologie, 175, 93 96.
  • 12
    Esch, F., Baird, A., Ling, N., Ueno, N., Hill, F., Deneroy, L. (1985) Primary structure of bovine fibroblastic growth factor (FGF) and comparison with the amino-terminal sequence of bovine brain acidic FGF. Proceedings of the National Academy of Sciences of the United States of America, 82, 6507 6511.
  • 13
    Folkman, J. (1995) Angiogenesis in cancer, vascular, rheumatoid and other disease. Nature Medicine, 1, 27 31.
  • 14
    Frank, S., Hubner, G., Breier, G., Longaker, M.T., Greenhalgh, D.G., Werner, S. (1995) Regulation of vascular endothelial growth factor expression in cultured keratinocytes: implications for normal and impaired wound healing. Journal of Biological Chemistry, 270, 1260 1267.
  • 15
    Freeman, M.R., Schneck, F.X., Gagnon, M.L., Corless, C., Soker, S., Niknejad, K., Peoples, G.E., Klagsbrun, M. (1995) Peripheral blood T lymphocytes and lymphocytes infiltrating human cancers express vascular endothelial growth factor: a potential role for T cells in angiogenesis. Cancer Research, 55, 4140 4149.
  • 16
    French Cooperative Group on Chronic Lymphocytic Leukaemia (1990) Natural history of stage A chronic lymphocytic leukaemia untreated patients. British Journal of Haematology, 76, 45 62.
  • 17
    Gasparini, G. & Harris, A.L. (1995) Clinical importance of the determination of tumor angiogenesis in breast carcinoma: much more than a new prognostic tool. Journal of Clinical Oncolology, 13, 765 782.
  • 18
    Hallek, M., Langenmayer, I., Nerl, C., Knauf, W., Dietzfelbinger, H., Adorf, D., Ostwald, M., Busch, R., Kuhn-Hallek, I., Thiel, E., Emmerich, B. (1999) Elevated serum thymidine kinase levels identify a subgroup at high risk of disease progression in early, nonsmoldering chronic lymphocytic leukemia. Blood, 93, 1732 1737.
  • 19
    Kini, A.R., Peterson, L.C., Kay, N.E. (1998) Evidence for abnormal angiogenesis in the bone marrow of patients with B-cell chronic lymphocytic leukemia. Blood, 92, (Suppl. 1), 717a.
  • 20
    Li, V.W., Folkerth, R.D., Watanabe, H. (1994) Microvessel count and cerebrospinal fluid basic fibroblast growth factor in children with brain tumours. Lancet, 344, 82 86.
  • 21
    Molica, S. (1991) Progression and survival studies in early chronic lymphocytic leukemia. Blood, 78, 895 899.
  • 22
    Molica, S. (1999) Is it time for a reassessment of prognostic features in B-cell chronic lymphocytic leukemia? Hematology and Cell Therapy, 41, 87 93.
  • 23
    Molica, S., Levato, D., Cascavilla, N., Levato, L., Musto, P. (1999) Clinico-prognostic implications of simultaneous increased serum levels of soluble CD23 and beta-2 microglobulin in B-cell chronic lymphocytic leukaemia. European Journal of Haematology, 62, 117 122.
  • 24
    Montserrat, E., Sanchez-Bisono, J., Vinolas, N., Rozman, C. (1986) Lymphocyte doubling time in chronic lymphocytic leukaemia: analysis of its prognostic significance. British Journal of Haematology, 62, 567 578.
  • 25
    Montserrat, E., Vinolas, N., Reverter, J.C., Rozman, C. (1988) Natural history of chronic lymphocytic leukemia: on the progression and prognosis of early stages. Nouvelle Revue Française d'Hématologie, 30, 359 361.
  • 26
    Morrison, V.A. (1998) The infectious complications of chronic lymphocytic leukemia. Seminars in Oncology, 25, 98 106.
  • 27
    Nakamura, T., Nawa, K., Ichiara, A. (1984) Partial purification and characterization of hepatocyte growth factor from serum of hepatomized rats. Biochemical and Biophysical Research Communications, 122, 1450 1459.
  • 28
    Perez-Atayade, A.R., Sallan, S.E., Tedrow, U., Connors, E.A., Folkman, J. (1997) Spectrum of tumor angiogenesis in the bone marrow of children with acute lymphoblastic leukemia. American Journal of Pathology, 150, 815 821.
  • 29
    Rai, K.R., Sawitsky, A., Cronkite, E.P., Chanana, A.D., Levy, N.R., Pasternack, B.S. (1975) Clinical staging of chronic lymphocytic leukemia. Blood, 46, 219 234.
  • 30
    Rozman, C., Montserrat, E., Rodriguez-Fernandez, J.M., Ayats, R., Vallespi, T., Parody, R., Rios, A., Prados, D., Morey, M., Gomis, F., Alcala, A., Gutierrez, M., Maldonado, J., Gonzales, G., Giralt, M., Hernandez-Nieto, L., Cabrera, A., Fernandez-Ranana, J.M. (1984) Bone marrow histologic pattern: the best single prognostic parameter in chronic lymphocytic leukemia: a multivariate survival analysis of 329 cases. Blood, 64, 642 653.
  • 31
    Salven, P., Maenpaa, H., Orpana, A., Alitalo, K., Joensuu, H. (1997) Serum VEGF is often elevated in disseminated cancer. Clinical Cancer Research, 6, 647 651.
  • 32
    Sarfati, M., Chevret, S., Chastang, C., Biron, G., Stryckmans, P., Delespesse, G., Binet, J.C., Merle-Beral, H., Bron, D. (1996) Prognostic importance of serum soluble CD23 level in chronic lymphocytic leukemia. Blood, 88, 4259 4264.
  • 33
    Shami, P.J., Hussong, J.W., Rodgers, G.M. (1998) Evidence of increased angiogenesis in the bone marrow of patients with acute nonlymphocytic leukemia. Blood, 92, (Suppl. 1), 512a.
  • 34
    Toi, M., Shinichi, K., Suzuki, H., Yamamoto, Y., Inada, K., Imazawa, T., Taniguchi, T., Tominaga, T. (1996) Quantitative analysis of vascular endothelial growth factor in primary breast cancer. Cancer, 77, 1101 1106.
  • 35
    Vacca, A., Ribatti, D., Presta, M., Minischetti, M., Iurlaro, M., Ria, R., Albini, A., Bussolino, F., Dammacco, F. (1999) Bone marrow neovascularization, plasma cell angiogenic potential, and matrix metalloproteinase-2 secretion parallel progression of human multiple myeloma. Blood, 93. 3064 3073.
  • 36
    Yamamoto, Y., Toi, M., Kondo, S., Matsumoto, T., Suzuki, H., Kitamura, M., Tsurata, K., Taniguchi, T., Okamoto, A., Mori, T., Yoshida, M., Ikeda, T., Tominaga, T. (1996) Concentrations of vascular endothelial growth factor in the sera of normal controls and cancer patients. Clinical Cancer Research, 2, 821 826.
View Full Article (HTML) Get PDF (152K)