Recombinant human factor VIIa in the management of amyloid-associated factor X deficiency


David Green, MD, PhD, 345 E Superior St-Room 1407, Chicago, IL 60611, USA. E-mail:


Factor X deficiency is an important complication of amyloidosis. It is associated with severe bleeding that is difficult to control with plasma or prothrombin complex concentrates. Splenectomy ameliorates the factor X deficiency, but achieving satisfactory haemostasis for this operation is problematic. We report that a new clotting concentrate, recombinant factor VIIa, readily controls bleeding and makes splenectomy feasible.