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Vitamin E correlates inversely with non-transferrin-bound iron in sickle cell disease
Article first published online: 20 DEC 2001
DOI: 10.1046/j.1365-2141.2001.03018.x
1365-2141/asset/cover.gif?v=1&s=340532f3ee73ba9171e38abd4d7f6a926d117661 "British Journal of Haematology")
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How to Cite
Marwah, S. S., Wheelwright, D., Blann, A. D., Rea, C., Beresford, R., Phillips, J. D., Wright, J. and Bareford, D. (2001), Vitamin E correlates inversely with non-transferrin-bound iron in sickle cell disease. British Journal of Haematology, 114: 917–919. doi: 10.1046/j.1365-2141.2001.03018.x
Publication History
- Issue published online: 20 DEC 2001
- Article first published online: 20 DEC 2001
- Received 12 February 2001; accepted for publication 18 May 2001
- Abstract
- Article
- References
- Cited By
Keywords:
- sickle cell disease;
- antioxidant activity;
- vitamin E;
- NTBI
Decreased serum vitamin E levels are found in homozygous sickle cell disease (SCD). Excessive transfusions may lead high non-transferrin-bound iron (NTBI). Hypothesizing a relationship between the two, vitamin E (measured using high performance liquid chromatography) was significantly lower in 30 SCD patients than in 30 age-/sex-matched controls (P < 0·001), but NTBI (bleomycin assay) was higher (P < 0·001). Vitamin E was lower in 10 transfused patients than in 20 non-transfused patients (P < 0·001) with a significant inverse correlation between the NTBI and vitamin E (r = −0·58, P < 0·001). NTBI associated with iron overload in SCD may increase the potential for oxidative damage and low vitamin E activity may compound this effect.