TAFI antigen and D-dimer levels during normal pregnancy and at delivery


Professor Philippe de Moerloose, Haemostasis Unit, Geneva University Hospital, 1211 Geneva 14, Switzerland. E-mail: philippe.deMoerloose@hcuge.ch


We have investigated whether the levels of thrombin-activatable fibrinolysis inhibitor (TAFI) were correlated with d-dimer levels during pregnancy and at delivery. From the 10th week of pregnancy to delivery, 519 samples from 144 women (mean age 29·3 ± 5, range 19–43) were obtained. We confirm the gradual increase of d-dimer levels, and provide reference intervals for d-dimer measurements throughout normal pregnancy. TAFI levels increased moderately during pregnancy but no inverse correlation with d-dimer levels was observed.