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Keywords:

  • platelets;
  • cyclooxygenase-1;
  • cyclooxygenase-2;
  • flow cytometry;
  • coronary artery bypass surgery

Summary. There are conflicting reports about the expression of cyclooxygenase (COX)-2 in human platelets. The present study describes a flow cytometric method for the measurement of platelet COX. Both COX-1 and COX-2 were shown to be expressed in platelets from patients undergoing a coronary artery bypass graft. There was a significant increase in COX-2 expression at day 5 as compared with pre-surgery values (mean fluorescence 12·31 ± 0·88 versus 9·15 ± 0·88; means ± SEM, n = 7, P < 0·05), whereas COX-1 levels did not change (13·45 ± 1·11 versus 12·38 ± 1·41; n = 7, P > 0·05).