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Successful non-myeloablative allogeneic transplantation for treatment of idiopathic hypereosinophilic syndrome

  1. Naoto T. Ueno1,2,
  2. Athanasios Anagnostopoulos1,
  3. Gabriela Rondón1,
  4. Richard E. Champlin1,
  5. N. Mikhailova3,
  6. O. S. Pankratova3,
  7. L. S. Zoubarovskaya3,
  8. E. V. Semenova3,
  9. B. V. Afanasyev3,
  10. Susan O'Brien4,
  11. Michael Andreeff1,
  12. Andrey Y. Zaritskey3

Article first published online: 2 OCT 2002

DOI: 10.1046/j.1365-2141.2002.03771.x

Issue

British Journal of Haematology

British Journal of Haematology

Volume 119, Issue 1, pages 131–134, October 2002

Additional Information

How to Cite

Ueno, N. T., Anagnostopoulos, A., Rondón, G., Champlin, R. E., Mikhailova, N., Pankratova, O. S., Zoubarovskaya, L. S., Semenova, E. V., Afanasyev, B. V., O'Brien, S., Andreeff, M. and Zaritskey, A. Y. (2002), Successful non-myeloablative allogeneic transplantation for treatment of idiopathic hypereosinophilic syndrome. British Journal of Haematology, 119: 131–134. doi: 10.1046/j.1365-2141.2002.03771.x

Author Information

  1. 1

    Department of Blood and Marrow Transplantation, and

  2. 2

    Department of Molecular and Cellular Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA, and

  3. 3

    Centre of Hematology, BMT Department, St Petersburg Pavlov State Medical University, St Petersburg, Russia, and

  4. 4

    Department of Leukaemia, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA

*Naoto T. Ueno, MD, PhD/Athanasios Anagnostopoulos, MD, Department of Blood and Marrow Transplantation, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard Box 448, Houston, TX 77030, USA. E-mail: nueno@mdanderson.org/aanagnos@mdanderson.org

Publication History

  1. Issue published online: 2 OCT 2002
  2. Article first published online: 2 OCT 2002
  3. Received 19 February 2002; accepted for publication 15 April 2002

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Keywords:

  • blood and marrow transplantation;
  • eosinophils;
  • idiopathic hypereosinophilic syndrome

Summary. In this report, we describe two patients with idiopathic hypereosinophilic syndrome (HES) who received a non-myeloablative allogeneic transplantation following a reduced-intensity preparative regimen of melphalan and fludarabine. In both cases, complete donor chimaerism and remission were achieved, and have lasted for more than 10 months. This report provides proof of principle for the feasibility of non-myeloablative transplantation for patients with idiopathic HES, who can show co-morbidity due to eosinophilic infiltration of their organs.

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