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References

  • AABB Extracorporeal Therapy Committee (1992) Guidelines for Therapeutic Hemapheresis: 1992–1993. American Association of Blood Banks, Bethesda.
  • Aird, W.C., Edelberg, J.M., Weiler-Guettler, H., Simmons, W.W., Smith, T.W. & Rosenberg, R.D. (1997) Vascular bed-specific expression of an endothelial cell gene is programmed by the tissue microenvironment. Journal of Cell Biology, 138, 11171124.
  • Allford, S.L., Harrison, P., Lawrie, A.S., Liesner, R., Mackie, I.J. & Machin, S.J. (2000) von Willebrand factor-cleaving protease activity in congenital thrombotic thrombocytopenic purpura. British Journal of Haematology, 111, 12151222.
  • Anthony, M.T., Zeigler, Z.R., Lister, J., Raymond, J.M., Shadduck, R.K., Kramer, R.E., Gryn, J.F., Rintels, P.B., Besa, E.C., George, J.N., Silver, B., Joyce, R. & Bodensteiner, D. (1998) Plasminogen activator inhibitor (PAI-1) antigen levels in primary TTP and secondary TTP post-bone marrow transplantation. American Journal of Hematology, 59, 914 .
  • Antunes, I., Magina, S., Grango, E., Eliseo, A., Lemos, R., Barros, M.A. & Mesquita-Guimaraes, J. (1999) Haemolytic uraemic syndrome induced by Pentostatin in a patient with cutaneous T cell lymphoma. Dermatology, 198, 179180.
  • Armstrong, G.D., Rowe, P.C., Goodyer, P., Orrbine, E., Klassen, T.P., Wells, G., Mackenzie, A., Lior, H., Blanchard, C., Auclair, F., Thompson, B., Rafter, D.J. & McLaine, P.N. (1995) A phase I study of chemically synthesized verotoxin (shiga-like toxin) Pk-trisaccharide receptors attached to chromosorb for preventing hemolytic–uremic syndrome. Journal of Infectious Diseases, 171, 10421045.
  • Asada, Y., Sumiyoshi, A., Hayashi, T., Suzumiya, J. & Kaketani, K. (1985) Immunohistochemistry of vascular lesion in thrombotic thrombocytopenic purpura, with special reference to factor VIII related antigen. Thrombosis Research, 38, 469479.
  • Barbot, J., Costa, E., Guerra, M., Barreirinho, M.S., Isvarlal, P., Lammle, B., Gerritsen, H.E. & Furlan, M. (2000) Ten years of prophylactic treatment with fresh frozen plasma in a child with chronic relapsing thrombotic thrombocytopenic purpura due to a congenital deficiency of vWF-cleaving protease. Haemostasis, 30, 193a.
  • Bast, D.J., Brunton, J.L., Karmali, M.A. & Richardson, S.E. (1997) Toxicity and immunogenicity of a Verotoxin 1 mutant with reduced globotriasyl ceramide receptor binding in rabbits. Infection and Immunity, 65, 20192028.
  • Bell, W.R., Braine, H.G., Ness, P.M. & Kickler, T.S. (1991) Improved survival in thrombotic thrombocytopenic purpura–hemolytic uremic syndrome. Clinical experience in 108 patients. New England Journal of Medicine, 325, 398403.
  • Bennet, C.L., Weinberg, P.D., Rozenberg-Ben-Dror, K., Yarnold, P.R., Kwaan, H.C. & Green, D. (1998) Thrombotic thrombocytopenic purpura is associated with ticlopidine. Annals of Internal Medicine, 128, 541544.
  • Bennet, C.L., Connors, J.M., Carwile, J.M., Moake, J.L., Bell, W.R., Tarantolo, S.R., McCarthy, L.J., Sarode, R., Hatfield, A.J., Michalets, E.L., Feldman, M.D., Davidson, C.J. & Tsai, H.-M. (2000) Thrombotic thrombocytopenic purpura associated with clopidogrel. New England Journal of Medicine, 342, 17731777.
  • Berns, J.S., Kaplan, B.S., Mackow, R.C. & Hefter, L.G. (1992) Inherited hemolytic uremic syndrome in adults. American Journal of Kidney Diseases, 29, 331334.
  • Bird, J.M., Cummins, D. & Machin, S.J. (1990) Cyclophosphamide for chronic relapsing thrombotic thrombocytopenic purpura. Lancet, 336, 565566.
  • Bobbio-Pallavicini, E., Porta, C., Centurioni, R., Gugliotta, L., Vianelli, N., Tacconi, F., Billio, A., Ascari, E. & the Italian Cooperative Group for TTP (1994) Vincristine sulfate for the treatment of thrombotic thrombocytopenic purpura refractory to plasma-exchange. European Journal of Haematology, 52, 222226.
  • Bobbio-Pallavicini, E., Gugliotta, L., Centurioni, R., Porta, C., Vianelli, N., Billio, A., Tacconi, F. & Ascari, E. for the Italian Co-operative Group for TTP (1997) Antiplatelet agents in thrombotic thrombocytopenic purpura (TTP). Results of a randomised multicenter trial by the Italian Cooperative Group for TTP. Haematologica, 82, 429435.
  • Bourke, B., Chan, V.L. & Sherman, P. (1998) Campylobacter upsaliensis: waiting in the wings. Clinical Microbiology Reviews, 11, 440449.
  • Cabrera, G.R., Fortenberry, J.D., Warshaw, B.L., Chambliss, C.R., Butler, J.C. & Cooperstone, B.G. (1998) Haemolytic uraemic syndrome associated with invasive streptococcus pneumoniae infection. Pediatrics, 101, 699703.
  • Carter, A.O., Borczyk, A.A., Carlson, J.A., Harvey, B., Hockin, J.C., Karmali, M.A., Krishnan, C., Korn, D.A. & Lior, H. (1987) A severe outbreak of Eschericia coli 0157:H7 associated haemorrhagic colitis in a nursing home. New England Journal of Medicine, 24, 14961500.
  • Chant, I., Milford, D. & Rose, P.E. (1994) Plasminogen activator inhibitor activity in diarrhoea associated haemolytic uraemic syndrome. Quarterly Journal of Medicine, 87, 737740.
  • Chintagumpala, M.M., Hurwitz, R.L., Moake, J.L., Mahoney, D.H. & Steuber, C.P. (1992) Chronic relapsing thrombotic thrombocytopenic purpura in infants with large von Willebrand factor multimers during remission. Journal of Paediatrics, 120, 4953.
  • Chua, S. & Redman, C.W. (1992) Prognosis for pre-eclampsia complicated by 5g or more of proteinuria in 24 hours. European Journal of Obstetrics, Gynecology and Reproductive Biology, 43, 912.
  • Cimolai, N., Morrison, B. & Carter, J. (1992) Risk factors for the central nervous system manifestations of gastroenteritis associated haemolytic uraemic syndrome. Paediatrics, 90, 616621.
  • Cimolai, N., Basalyga, S., Mah, D.G., Morrison, B.J. & Carter, J.E. (1994) A continuing assessment of risk factors for the development of Eschericia coli 0157:H7 associated haemolytic uraemic syndrome. Clinical Nephrology, 42, 8589.
  • Crowther, M.A., Heddle, N., Hayward, C.P.M., Warkentin, T. & Kelton, J.G. (1996) Splenectomy done during hematologic remission to prevent relapse in patients with thrombotic thrombocytopenic purpura. Annals of Internal Medicine, 125, 294296.
  • Dent, J.A., Galbusera, M. & Ruggeri, Z.M. (1991) Heterogeneity of plasma von Willebrand factor multimers resulting from proteolysis of the constituent subunit. Journal of Clinical Investigation, 88, 774782.
  • Drake, T.A., Cheng, J., Chang, A. & Taylor, Jr, F.B. (1993) Expression of tissue factor, thrombomodulin, and E-selectin in baboons with lethal Eschericia coli sepsis. American Journal of Pathology, 142, 14581470.
  • Dundas, S. & Todd, A. (1999) The clinical management of E. coli 0157 infection. CPD Infection, 1, 1419.
  • Dundas, S., Murphy, J., Soutar, R.L., Jones, G.A., Hutchinson, S.J. & Todd, W.T.A. (1999) Effectiveness of therapeutic plasma exchange in the 1996 Lanarkshire Eschericia coli 0157:H7 outbreak. Lancet, 354, 13271330.
  • Dundas, S., Todd, W.T., Stewart, A.I., Murdoch, P.S., Chaudhuri, A.K. & Hutchinson, S.J. (2001) The central Scotland 1996 Eschericia coli 0157 outbreak: predicotors of haemolytic uraemic syndrome/thrombotic thrombocytopenic purpura and death. Clinical Infectious Diseases, 33, 923931.
  • Evans, G., Llewelyn, C., Luddington, R., Baglin, T.P. & Williamson, L.M. (1999) Solvent/detergent fresh frozen plasma as primary treatment of acute thrombotic thrombocytopenic purpura. Clinical and Laboratory Haematology, 21, 119123.
  • Ezra, Y., Rose, M. & Eldor, A. (1996) Therapy and prevention of thrombotic thrombocytopenic purpura during pregnancy: a clinical study of 16 pregnancies. American Journal of Hematology, 51, 16.
  • Fang, J.S., Chen, J.B., Chen, W.T. & Hsu, K.T. (1999) Haemolytic uraemic syndrome in an adult male with Aeromonas hydrophilia enterocolitis. Nephrology, Dialysis and Transplantation, 14, 439440.
  • Fujikawa, K., Suzuki, H., McMullen, B. & Chung, D. (2001) Purification of human von Willebrand factor-cleaving protease and its identification as a new member of the metalloproteinase family. Blood, 98, 16621666.
  • Fung, M.C., Storniolo, A.M., Nguyen, B., Arning, M., Brookfield, W. & Vigil, J. (1999) A review of haemolytic uraemic syndrome in patients with gemcitabine therapy. Cancer, 85, 20232032.
  • Furlan, M., Robles, R. & Lämmle, B. (1996) Partial purification and characterization of a protease from human plasma cleaving von Willebrand factor to fragments produced by in vivo proteolysis. Blood, 87, 42234234.
  • Furlan, M., Robles, R., Solenthaler, M., Wassmer, M., Sandoz, P. & Lämmle, B. (1997) Deficient activity of von Willebrand factor-cleaving protease in chronic relapsing thrombotic thrombocytopenic purpura. Blood, 89, 30973103.
  • Furlan, M., Robles, R., Galbusera, M., Remuzzi, G., Kyrle, P.A., Brenner, B., Krause, M., Scharrer, I., Aumann, V., Mittler, U., Solenthaler, M. & Lämmle, B. (1998) Von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura and the hemolytic–uremic syndrome. New England Journal of Medicine, 339, 15781584.
  • Gaddis, T.G., Guthrie, T.H.J., Drew, M.J., Sahud, M., Howe, R.B. & Mittelman, A. (1997) Treatment of plasma refractory thrombotic thrombocytopenic purpura with protein A immunoabsorption. American Journal of Hematology, 55, 5558.
  • Gasser, C., Gautier, E., Steck, A., Siebenmann, R.E. & Oechslin, R. (1955) Hämolytisch–urämische syndrome: bilaterale nierendrinndennekrosen bei akuten erworbenen hämolytischen anämien. Scweizerische Medizinische Wochenschrift, 85, 905909.
  • Gerritsen, H.E., Robles, R., Lämmle, B. & Furlan, M. (2001) Partial amino acid sequence of purified von Willebrand factor-cleaving protease. Blood, 98, 16541661.
  • Gianviti, A., Perna, A., Caringella, A., Edefonti, A., Penza, R., Remuzzi, G. & Rizzoni, G. (1993) Plasma exchange in children with hemolytic–uremic syndrome at risk of poor outcome. American Journal of Kidney Diseases, 22, 264266.
  • Gordon, L.I., Kwaan, H.C. & Rossi, E.C. (1987) Deleterious effects of platelet transfusions and recovery thrombocytosis in patients with thrombotic microangiopathy. Seminars in Hematology, 24, 194201.
  • Grif, K., Dierich, M.P., Karch, H. & Allerberger, F. (1998) Strain-specific differences in the amount of Shiga toxin released from enterohemorrhagic Eschericia coli following exposure to sub inhibitory concentrations of antimicrobial agents. European Journal of Clinical Microbiology and Infectious Diseases, 17, 761766.
  • Hagley, M.T., Hosney, I.A., Hulisz, D.T. & Davis, H.H. (1992) Haemolytic uraemic syndrome associated with ingestion of quinine. American Journal of Nephrology, 12, 192195.
  • Hand, J.P., Lawlor, E.R., Yong, C.K.K. & Davis, J.H. (1998) Successful use of cyclosporin A in the treatment of refractory thrombotic thrombocytopenic purpura. British Journal of Haematology, 100, 597599.
  • Harkness, D.R., Byrnes, J.J., Lian, E.C.-Y., Williams, W.D. & Hensley, G.T. (1981) Hazard of platelet transfusion in thrombotic thrombocytopenic purpura. Journal of the American Medical Association, 246, 19311933.
  • Harrison, C.N., Lawrie, A.S., Iqbal, A., Hunter, A. & Machin, S.J. (1996) Plasma exchange with solvent/detergent-treated plasma of resistant thrombotic thrombocytopenic purpura. British Journal of Haematology, 94, 756758.
  • Hayman, R., Brockelsby, J., Kenny, L. & Baker, P. (1999) Preeclampsia: the endothelium, circulating factor(s) and vascular endothelial growth factor. Journal of the Society for Gynecological Investigation, 6, 310.
  • Hayward, C.P.M., Sutton, D.M.C., Carter, Jr, W.H. Campbell, E.D. Scott, J.G. Francombe, W.H. Shumak K.H. & Baker M.A. (1994) Treatment outcomes in patients with adult thrombotic thrombocytopenic purpura–haemolytic syndrome. Archives of Internal Medicine, 154, 982987.
  • Hebert, P.C. Wells, G. Blajchman, M.A. Marshall, J. Martin, C. Pagliarello, G. Tweed, M. Schweitzer I. & Yetisir E. (1999) A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. New England Journal of Medicine, 340, 409417.
  • Hoorntje, S.J. Prins, E.J.L. Smit A.J. & Donker A.J.M. (1981) Reversal of long-standing renal insufficiency by captopril in a patient with relapsing hemolytic uremic syndrome due to an oral contraceptive. Annal of Internal Medicine, 94, 355357.
  • Huang, J.-J. Chen, M.-W. Sung, J.-M. Lan, R.R. Wang, M.C. & Chen F.F. (1998) Post partum haemolytic uraemic syndrome associated with antiphospholipid antibody. Nephrology, Dialysis and Transplantation, 13, 182186.
  • Hubel C.A. (1999) Oxidative stress in the pathogenesis of preeclampsia. Proceedings of the Society for Experimental Biology and Medicine, 222, 222235.
  • Hunt, B. Lämmle, B. Haycock G. & Furlan M. (2001) von Willebrand factor cleaving protease in childhood diarrhoea associated haemolytic uraemic syndrome. Thrombosis and Haemostasis, 85, 975978.
  • Hunt B.J. & Jurd, K.M. (1998) Endothelial cell activation. British Medical Journal, 316, 13281329.
  • Kahra, K. Draganov, B. Sund S. & Hovig T. (1998) Post partum renal failure: a complex case with probable coexistence of hemolysis, elevated liver enzymes, low platelet count, and haemolytic uremic syndrome. Obstetrics and Gynaecology, 92, 698700.
  • Kaplan, B.S. Meyers K.E. & Schulman, S.L. (1998) The pathogenesis and treatment of hemolytic uremic syndrome. Journal of the American Society of Nephrology, 9, 11261133.
  • Karch, H. Janetzki-Mittmann, C. Aleksic, S. & Datz, M. (1995) Isolation of enterohaemorrhagic Eschericia coli 0157 strain from patients with haemolytic uramic syndrome by using immunomagnetic separation, DNA based methods and direct culture. Journal of Clinical Microbiology, 34, 516519.
  • Karpman, D. Holmberg, L. Jirgård, L. & Lethagen, S. (1996) Increased platelet retention in familial recurrent thrombotic thrombocytopenic purpura. Kidney International, 49, 190199.
  • Karpman, D. Lethagen, S. Kristoffersson, A.C. Isaksson, C. & Holmberg, L. (1997) von Willebrand factor mediates increased platelet retention in recurrent thrombotic thrombocytopenic purpura. Thrombosis and Haemostasis, 78, 14561462.
  • Katoh, M. & Shigematsu, H. (1999) Renal involvement of thrombotic thrombocytopenic purpura: special reference to the glomeruloid structures. Pathology International, 49, 638642.
  • Kincaid-Smith, P. Fairley, K.F. & Kloss, M. (1988) Lupus anticoagulant associated with renal thrombotic microangiopathy and pregnancy-related renal failure. Quarterly Journal of Medicine, 258, 795851.
  • Kniaz, D. Eisenberg, G.M. Elrad, H. Johnson, G.A. Valaitis, J. & Bregman, H. (1992) Post partum hemolytic–uraemic syndrome associated with antiphospholipid antibodies. American Journal of Nephrology, 12, 126133.
  • Kohli, H.S. Sud, K. Jha, V. Gupta, K.L. Minz, M. Joshi, K. & Sakhuja, V. (1998) Cyclosporin induced haemolytic uraemic syndrome presenting as primary graft dysfunction. Nephrology, Dialysis and Transplantation, 13, 29402942.
  • Kovacs, M.J. Roddy, J. Gregoire, S. Cameron, W. Eidus, L. & Drouin, J. (1990) Thrombotic thrombocytopenic purpura following hemorrhagic colitis due to Escherichia coli 0157:H7. American Journal of Medicine, 88, 177179.
  • Koyama, T. Suehiro, A. Kakishita, E. Taira, S. Isojima, S. Norioka, M. & Ito, K. (1990) Efficiency of the high molecular weight fraction of plasma for the maintenance of pregnancy associated with thrombotic thrombocytopenic purpura. American Journal of Hematology, 35, 179183.
  • Kusunoki, Y. Nobumoto, K. Ohkawa, M. Watanabe, T. Hamada, I. & Tochimaru, H. (1998) Gabexate mesilate plus intravenous gammaglobulin treatment in children with diarrhoea–associated haemolytic uraemic syndrome. Nephron, 79, 227228.
  • Lämmle, B. Robles, R. & Furlan, M. (2001) Severe constitutional deficiency of von Willebrand factor-cleaving protease (vWF-cp) in 23 patients with familial thrombotic thrombocytopenic purpura. Thrombosis and Haemostasis, a.
  • Levy, G.G. Nichols, W.C. Lian, E.C. Foroud, T. McClintock, J.N. McGee, B.M. Yang, A.Y. Siemieniak, D.R. Stark, K.R. Gruppo, R. Sarode, R. Shurin, S.B. Chandrasekaran, V. Stabler, S.P. Sabio, H. Bouhassira, E.E. Upshaw, J.D. Ginsburg, D. & Tsai, H.-M. (2001) Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura. Nature, 413, 488494.
  • Lian, E.C.-Y. Brynes, J.J. & Harkness, D.R. (1984) Two successful pregnancies in women with chronic thrombotic thrombocytopenic purpura treated by plasma infusion. American Journal of Hematology, 16, 287291.
  • Lingwood, C.A. Law, H. Richardson, S. Petric, M. Brunton, J.L. De Grandis, S. & Karmali, M. (1987) Glycolipid binding of purified and recombinant E. coli produced verotoxin in vitro. Journal of Biological Chemistry, 262, 88348839.
  • Loirat, C. Beafils, F. Sonsino, E. Schlegel, N. Guesnu, M. Pillion, G. Andre, J.L. Broyer, M. Guyot, C. & Habib, R. (1984) Traitement du syndrome hemolytique et uremique de l'enfant par l'urokinase, Essai controle cooperatif. Archives Francaises Pediatrie, 41, 1519.
  • Loirat, C. Sonsino, E. Hinglais, N. Jais, J.P. Landais, P. & Fermanian, J. (1988) Treatment of childhood haemolytic uraemic syndrome with plasma. A multicentre randomised controlled trial. Pediatric Nephrology, 2, 279285.
  • Loof, A.H. Van Vliet, H.H.D.M. & Kappers-Klune, M.C. (2001) Low activity of von Willebrand factor-cleaving protease is not restricted to patients suffering from thrombotic thrombocytopenic purpura. British Journal of Haematology, 112, 10871088.
  • Lucas, M. Rose, P.E. & Morris, A. (2000) Contrasting effects of HSP 72 expression on apoptosis in human umbilical vein endothelial cells and an angiogenic cell line EC304. British Journal of Haematology, 110, 957964.
  • Mabie, W.C. Barton, J.R. & Sibai, B. (1997) Septic shock in pregnancy. Obstetrics and Gynaecology, 90, 553561.
  • Magann, E.F. Bass, D. Chauhan, S.P. Sullivan, D.L. Martin, R.W. Martin, Jr, J.N. (1994a) Antepartum corticosteroids: disease stabilization in patients with the syndrome of hemolysis, elevated liver enzymes, and low platelets (HELLP). American Journal of Obstetrics and Gynecology, 171, 11481153.
  • Magann, E.F., Perry, K.G., Meydrech, E.F., Harris, R.L., Chauhan, S.P. & Martin, Jr, J.N. (1994b) Post partum corticosteroids: accelerated recovery from the syndrome of hemolysis, elevated lever enzymes, and low platelets (HELLP). American Journal of Obstetrics and Gynecology, 171, 11541158.
  • De Man, A.M., Smulders, Y.M., Roozendaal, K.J. & Frissen, P.H. (1997) HIV-related thrombotic thrombocytopenic purpura: report of two cases and a review of the literature. Netherlands Journal of Medicine, 51, 103109 .
  • Mannucci, P.M., Canciani, M.T., Forza, I., Lussana, F., Lattuada, A. & Rossi, E. (2001) Changes in health and disease of the metalloprotease that cleaves von Willebrand factor. Blood, 98, 27302735.
  • Martin, J.N., Files, J.C., Blake, P.G., Norman, P.H., Martin, R.W., Hess, L.W., Morrison, J.C. & Wiser, W.L. (1990) Plasma exchange for pre-eclampsia: post partum use for persistently severe pre-eclampsia–eclampsia with HELLP syndrome. American Journal of Obstetrics and Gynecology, 162, 126137.
  • Martin, J.N., Perry, K.G., Roberts, W.E., Files, J.C., Norman, P.F., Morrison, J.C. & Blake, P.G. (1994a) Plasma exchange for pre-eclampsia: immediate peripartum utilization for selected patients with HELLP syndrome. Journal of Clinical Apheresis, 9, 162165.
  • Martin, J.N., Perry, K.G., Roberts, W.E., Normanes, J.C., Blake, P.G., Morrison, J.C. & Wiser, W.L. (1994b) Plasma exchange for pre-eclampsia: unsuccessful antepartum utilization for severe pre-eclampsia with or without HELLP syndrome. Journal of Clinical Apheresis, 9, 155161.
  • Martin, J.N., Perry, K.G., Blake, P.G., May, W.A., Moore, A. & Robinette, L. (1997) Better maternal outcomes are achieved with dexamethasone therapy for post partum HELLP (hemolysis, elevated liver enzymes, and thrombocytopenia) syndrome. American Journal of Obstetrics and Gynecology, 177, 10111017.
  • Martinez, C., Muñiz-Díaz, E., Pastoret, C., Sanchez, I., Ramos, A., Ciendones, M., Montero, A. & Madoz, P. (2000) Experience with methylene blue virus-inactivated plasma in the treatment of thrombotic thrombocytopenic purpura (TTP). Vox Sanguines, 78, P224a.
  • Martinez-Roman, S., Gratacos, E., Torne, A., Torra, R., Carmona, F. & Cararach, V. (1996) Successful pregnancy in a patient with hemolytic–uremic syndrome during the second trimester of pregnancy. Journal of Reproductive Medicine, 41, 211214.
  • Mazzei, C., Pepkowitz, S., Klapper, E. & Goldfinger, D. (1998) Treatment of thrombotic thrombocytopenic purpura: a role for early vincristine administration. Journal of Clinical Apheresis, 13, 2022.
  • Milford, D.V., Taylor, C.M., Guttridge, B., Hall, S.M., Rowe, B. & Kleanthous, H. (1990) Haemolytic uraemic syndrome in the British Isles 1985–88: association with verotoxin producing Eschericia coli. Part I: Clinical and epidemiological aspects. Archives of Disease in Childhood, 65, 716721.
  • Milford, D., Staten, J., MacGreggor, I., Dawes, J., Taylor, C.M. & Hill, F.G. (1991) Prognostic markers in diarrhoea associated haemolytic uraemic syndrome: initial neutrophil count, neutrophil elastase and von Willebrand antigen. Nephrology, Dialysis and Transplantation, 6, 232237 .
  • Moake, J.L., Byrnes, J.J., Troll, J.H., Rudy, C.K., Hong, S.L., Weinstein, M.J. & Colannino, N.M. (1985) Effects of fresh-frozen plasma and its cryosupernatant fraction on von Willebrand factor multimeric forms in chronic relapsing thrombotic thrombocytopenic purpura. Blood, 65, 12321236.
  • Moake, J.L. & McPherson, P.D. (1989) Abnormalities of von Willebrand factor multimers in thrombotic thrombocytopenenic purpura and the haemolytic uraemic syndrome. American Journal of Medicine, 87, 3N9N.
  • Moake, J., Chintagumpala, M., Turner, N., McPherson, P., Nolasco, L., Steuber, C., Santiago-Borrero, P., Horowitz, M. & Pehta, J. (1994) Solvent/detergent-treated plasma suppresses shear-induced platelet aggregation and prevents episodes of thrombotic thrombocytopenic purpura. Blood, 84, 490497.
  • Moghal, N.E., Ferreira, M.A., Howie, A.J., Milford, D.V., Raafat, E. & Taylor, C.M. (1998) The late histologic findings in diarrhea associated hemolytic uremic syndrome. Journal of Pediatrics, 132, 220223.
  • Mokrzycki, M.H. & Kaplan, A.A. (1994) Therapeutic plasma exchange: complications and management. American Journal of Kidney Diseases, 23, 817827.
  • Molinari, E., Costamagna, L., Perotti, C., Isernia, P., Pagani, A. & Salvaneschi, L. (1993) Refractory thrombotic thrombocytopenic purpura: successful treatment by plasmapheresis with plasma cryosupernatant. Haematologica, 78, 389392.
  • Monnens, L., Drayer, J. & De Jong, M. (1981) Malignant hypertension in a child with hemolytic–uremic syndrome treated with captopril. Acta Paediatrica Scandinavica, 70, 583585.
  • Monteagudo, J., Pereira, A., Reverter, J.C., Pijoan, J., Tusell, J., Puig, L., Ordinas, A. & Castillo, R. (1991) Thrombin generation and fibrinolysis in the thrombotic thrombocytopenic purpura and the hemolytic–uremic syndrome. Thrombosis and Haemostasis, 66, 515519.
  • Morrison, D.M., Tyrell, D.L. & Jewell, L.D. (1986) Colonic biopsy in verotoxin-induced hemorrhagic colitis and thrombotic thrombocytopenic purpura (TTP). American Journal of Clinical Pathology, 86, 108112.
  • Moschowitz, E. (1924) Hyaline thrombosis of the terminal arterioles and capillaries: a hitherto undescribed disease. Proceedings of the New York Pathological Society, 24, 2124.
  • Muttukrishna, S., Knight, P.G., Groome, N.P., Redman, C.W. & Ledger, W.L. (1997) Activin A and inhibin A as possible endocrine markers for pre-eclampsia. Lancet, 349, 12851288.
  • Nataro, J.P. & Kaper, J.B. (1998) Diarrheagenic Eshericia coli. Clinical Microbiology Reviews, 11, 142201.
  • Noris, M., Ruggenenti, P., Perna, A., Orisio, S., Caprioli, J., Skerka, C., Vasile, B., Zipfel, P.F. & Remuzzi, G. on behalf of the Italian Registry of Familial and Recurrent Hemolytic Uremic Syndrome/Thrombotic Thrombocytopenia Purpura (1998) Hypocomplementemia discloses genetic predisposition to hemolytic uremic syndrome and thrombotic thrombocytopenic purpura: role of factor H abnormalities. Journal of the American Society of Nephrology, 10, 281293.
  • O'Connor, N.T.J., Bruce-Jones, P. & Hill, L.F. (1992) Vincristine therapy for thrombotic thrombocytopenic purpura. American Journal of Hematology, 39, 234236.
  • O'Regan, S., Chesney, R. & Montear, J. (1980) Aspirin and dipyridamole therapy in the haemolytic uraemic syndrome. Journal of Paediatrics, 97, 473476.
  • Obrig, T.G., Moran, T.P. & Brown, J.E. (1987) The mode of action of Shiga toxin on peptide elongation of eukaryotic protein synthesis. Biochemical Journal, 244, 287294.
  • Odendaal, H.J., Pattison, R.C., Bam, R., Grove, D. & Kotze, T.J. (1990) Aggressive or expectant management for patients with severe preeclampsia between 28 and 34 weeks' gestation: a randomised controlled trial. Obstetrics and Gynaecology, 76, 10701075.
  • Ohali, M., Shalev, H., Schlesinger, M., Katz, Y., Kachko, L., Carmi, R., Sofer, S. & Landau, D. (1998) Hypocomplementemic autosomal recessive hemolytic uremic syndrome with decreased factor H. Pediatric Nephrology, 12, 619624.
  • Oleksowicz, L., Bhagwati, N. & DeLeon-Fernandez, M. (1999) Deficient activity of von Willebrand's factor-cleaving protease in patients with disseminated malignancies. Cancer Research, 59, 22442250.
  • Page, N.M., Woods, R.J., Gardiner, S.M., Lomthaisong, K., Gladwell, R.T., Butlin, D.J., Manyonda, I.T. & Lowry, P.J. (2000) Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia. Nature, 15, 797800.
  • Pasquale, D., Vidhya, R., DaSilva, K., Tsan, M.-F., Lansing, L. & Chikkappa, G. (1998) Chronic relapsing thrombotic thrombocytopenic purpura: role of therapy with cyclosporine. American Journal of Hematology, 57, 5761.
  • Peces, R., Diaz-Corte, C., Bultar, J., Seco, M. & Alvarez-Grande, J. (1998) Haemolytic uraemic syndrome in a heroin addict. Nephrology, Dialysis and Transplantation, 13, 31973199.
  • Pereira, A., Mazzara, R., Monteagudo, J., Sanz, C., Puig, L., Martinez, A., Ordinas, A. & Castillo, R. (1995) Thrombotic thrombocytopenic purpura/hemolytic uremic syndrome: a multivariate analysis of factors predicting the response to plasma exchange. Annals of Hematology, 70, 319323.
  • Perez, N., Spizzirri, F., Rahman, R., Suarez, A., Larrubia, C. & Lasarte, P. (1998) Steroids in the hemolytic uremic syndrome. Pediatric Nephrology, 12, 101104.
  • Perotti, C., Torretta, L., Molinari, E. & Salvaneschi, L. (1996) Cryoprecipitate-poor plasma fraction (cryosupernatant) in the treatment of thrombotic thrombocytopenic purpura at onset. A report of four cases. Haematologica, 81, 175177.
  • Van Der Plas, R.M., Schiphorst, M.E., Huizinga, E.G., Hene, R.J., Verdonck, L.F., Sixma, J.J. & Horowitz, M. (1999) von Willebrand factor proteolysis is deficient in classic, but not in bone marrow-associated thrombotic thrombocytopenic purpura. Blood, 93, 37983802.
  • Proesmans, W. & Eeckels, R. (1974) Has heparin changed the prognosis of the hemolytic–uremic syndrome. Clinical Nephrology, 2, 169173.
  • Ray, P.E., Liu, X.H., Xu, L. & Rakusan, T. (1999) Basic fibroblast growth factor in HIV-associated hemolytic uremic syndrome. Pediatric Nephrology, 13, 586593.
  • Redman, C.W. & Sargent, I.L. (2000) Placental debris, oxidative stress and pre-eclampsia. Placenta, 21, 597602.
  • Redman, C.W., Sacks, G.P. & Sargent, I.L. (1999) Preeclampsia: an excessive maternal inflammatory response to pregnancy. American Journal of Obstetrics and Gynecology, 180, 499506.
  • Remuzzi, G. & Ruggenenti, P. (1995) The hemolytic uremic syndrome. Kidney International, 48, 219.
  • Remuzzi, G., Galbusera, M., Salvadori, M., Rizzoni, G., Paris, S. & Ruggenenti, P. (1996) Bilateral nephrectomy stopped disease progression in plasma-resistant hemolytic uremic syndrome with neurological signs and coma. Kidney International, 49, 282286.
  • Reymond, D., Johnson, R.P., Karmali, M.A., Petric, M., Winkler, M., Johnson, S., Rahn, K., Renwick, S., Wilson, J., Clarke, R.C. & Spika, J. (1996) Neutralising antibodies to Eschericia coli Vero Cytotoxin 1 and antibodies to 0157 lipopolysaccharide in healthy farm family members and urban residents. Journal of Clinical Microbiology, 34, 20532057.
  • Riely, C.A. (1987) Acute fatty liver of pregnancy. Seminars in Liver Disease, 7, 4754 .
  • Rizzoni, G., Claris-Appiani, A., Edefonti, A., Facchin, P., Franchini, F., Gusmano, R., Imbasciati, E., Pavanello, L., Perfumo, F. & Remuzzi, G. (1988) Plasma infusion for hemolytic uremic syndrome in children: results of a multicenter controlled trial. Journal of Pediatrics, 12, 284290.
  • Robson, J.S., Martin, A.M., Ruckley, V. & Macdonald, M.K. (1968) Irreversible post-partum renal failure: a new syndrome. Quarterly Journal of Medicine, 37, 423435.
  • Robson, W.L., Leung, A.K. & Montgomery, M.D. (1991a) Causes of death in hemolytic uremic syndrome. Child Nephrology and Urology, 11, 8486.
  • Robson, W.L., Fick, G.H., Jadavji, T. & Leung, A.K. (1991b) The use of intravenous gammaglobulin in the treatment of typical hemolytic uremic syndrome. Pediatric Nephrology, 5, 289292.
  • Rock, G., Kelton, J.G., Shumak, K.H., Buskard, N.A., Sutton, D.M.C., Benny, W.B. & members of the Canadian Aphereis Group (1998) Laboratory abnormalities in thrombotic thrombocytopenic purpura. British Journal of Haematology, 103, 10311036.
  • Rock, G.A., Shumak, K.H., Buskard, N.A., Blanchette, V.S., Kelton, J.G., Nair, R.C., Spasoff, R.A. & the Canadian Apheresis Group (1991) Comparison of plasma exchange with plasma infusion in the treatment of thrombotic thrombocytopenic purpura. New England Journal of Medicine, 325, 393397.
  • Rock, G., Shumak, K.H., Sutton, D.M.C., Buskard, N.A., Nair, R.C., Michelson, A.D. & members of the Canadian Apheresis Group (1996) Cryosupernatant as replacement fluid for plasma exchange in thrombotic thrombocytopenic purpura. British Journal of Haematology, 94, 383386.
  • Rose, M. & Eldor, A. (1987) High incidence of relapses in thrombotic thrombocytopenic purpura. Clinical study of 38 patients. American Journal of Medicine, 83, 437444.
  • Rose, P. & Chant, I. (1998) Hematology of hemolytic–uremic syndrome. In: Eschericia coli 0157:H7 and other Shiga Toxin-Producing E. coli Strains (ed. by J.B. Kaper & A.D. O'Brien), p. 293. American Society for Microbiology, Washington.
  • Rose, P.E., Enayat, S.M., Sunderland, R., Short, P.E., Williams, C.E. & Hill, F.G.H. (1984) Abnormalities of factor VIII related protein multimers in the haemolytic uraemic syndrome. Archives of Disease in Childhood, 59, 11351140.
  • Rosove, M.H., Ho, W.G. & Goldfinger, D. (1982) Ineffectiveness of aspirin and dipyridamole in the treatment of thrombotic thrombocytopenic purpura. Annals of Internal Medicine, 96, 2733.
  • Rougier, N., Kazatchkine, M.D., Rougier, J.-P., Fremeaux-Bacchi, V., Blouin, J., Deschenes, G., Soto, B., Badouin, V., Pautard, B., Proesmans, W., Weiss, E. & Weiss, L. (1998) Human complement factor H deficiency associated with hemolytic uremic syndrome. Journal of the American Society of Nephrology, 9, 23182326.
  • Ruggenenti, P. & Remuzzi, G. (1996) Malignant vascular disease of the kidney: nature of the lesions, mediators of disease progression, and the case for bilateral nephrectomy. American Journal of Kidney Diseases, 27, 459475.
  • Ruggeneti, P. & Remuzzi, G. (1998) Pathophysiology and management of thrombotic microangiopathy. Journal of Nephrology, 11, 300310.
  • Sagripanti, A., Carpi, A., Baicchi, U., Morganti, M., Rosaia, B., Nicolini, A. & Mittermayer, C. (1996) Plasmatic parameters of coagulation activation in thrombotic microangiopathy. Biomedicine and Pharmacotherapy, 50, 357362.
  • Sarode, R., Gottschall, J.L., Aster, R.H. & McFarland, J.G. (1997) Thrombotic thrombocytopenic purpura: early and late responders. American Journal of Hematology, 54, 102107.
  • Schiebe, M., Hoffman, W., Belka & Bamberg, M. (1998) Mitomycin C-related haemolytic uraemic syndrome in cancer patients. Anticancer Drugs, 9, 433435.
  • Schmidt, R.H., Lenz, T., Grone, H.J., Geiger, H. & Scheuermann, E.H. (1999) Haemolytic uraemic syndrome after tacrolimus rescue therapy for cortisone-resistant rejection. Nephrology, Dialysis and Transplantation, 14, 979983.
  • Schwartz, M.L. & Brenner, W. (1985) Severe preeclampsia with persistent post partum hemolysis and thrombocytopenia treated by plasmapheresis. American Journal of Obstetrics and Gynecology, 65, s53– s55.
  • Seigler, R. (1994) Spectrum of extrarenal involvement in post diarrheal haemolytic uraemic syndrome. Journal of Paediatrics, 125, 511518.
  • Shumak, K.H., Rock, G.A., Nair, R.C. & the Canadian Apheresis Group (1995) Late relapses in patients successfully treated for thrombotic thrombocytopenic purpura. Annals of Internal Medicine, 122, 569572.
  • Sibai, B.M. & Ramadan, M.K. (1993) Acute renal failure in pregnancies complicated by hemolysis, elevated liver enzymes and low platelets. American Journal of Obstetrics and Gynecology, 168, 16821690.
  • Sibai, B.M., Spinnato, J.A., Watson, D.L., Hill, G.A. & Anderson, G.D. (1984) Pregnancy outcome in 303 cases with severe preeclampsia. Obstetrics and Gynaecology, 64, 319325.
  • Sibai, B.M., Ramadan, M.K., Usta, I., Salama, M., Mercer, B.M. & Friedman, S.A. (1993) Maternal morbidity and mortality in 442 pregnancies with hemolysis, elevated liver enzymes, and low platelets (HELLP syndrome). American Journal of Obstetrics and Gynecology, 169, 10001006.
  • Sibai, B.M., Mercer, B.M., Schiff, E. & Friedman, S.A. (1994) Aggressive versus expectant management of severe preeclampsia at 28–32 weeks' gestation: a randomzed controlled trial. American Journal of Obstetrics and Gynecology, 171, 818822.
  • Sibai, B.M., Ramadan, M.K., Chari, R.S. & Friedman, S.A. (1995) Pregnancies complicated by HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets): subsequent pregnancy outcome and long-term prognosis. American Journal of Obstetrics and Gynecology, 172, 125129.
  • Strutz, F., Wieneke, U., Braess, J., Kaboth, U., Kneba, M., Rumpf, K.W., Grupp, C. & Müller, G.A. (1998) Treatment of relapsing thrombotic thrombocytopenic purpura with cyclophosphamide pulse therapy. Nephrology, Dialysis and Transplantation, 13, 13201321.
  • Tassinari, D., Sartori, S., Panzini, I., Ravaioli, A. & Iorio, D. (1999) Hemolytic uremic syndrome during therapy with estramustine phosphate for advanced prostatic cancer. Oncology, 56, 112133.
  • Te Loo, D.M., Monnens, L.A., Van der Velden, T.J., Vermeer, M.A., Preyers, F., Demacker, P.N., Van Den Heuvel, L.P. & Van Hinsbergh, V.W. (2000) Binding and transfer of verocytotoxin by polymorphonuclear leukocytes in hemolytic uremic syndrome. Blood, 95, 33963402.
  • Tesh, V. & O'Brien, A. (1991) The pathogenic mechanisms of Shiga toxin and the shiga-like toxins. Molecular Microbiology, 5, 18171822.
  • The Eclampsia Trial Collaborative Group (1995) Which anticonvulsant for women with eclampsia? Evidence from the Collaborative Eclampsia Trial. Lancet, 345, 14551463.
  • Tobe, T.J., Franssen, C.J., Zijlstra, J.G., De Jong, P.E. & Stegeman, C.A. (1999) Hemolytic uremic syndrome due to Caprocytophaga canimorsus bacteraemia after a dog bite. American Journal of Kidney Diseases, 33, E5.
  • Torok, T.J., Holman, R.C. & Chorba, T.L. (1995) Increasing mortality from thrombotic thrombocytopenic purpura in the United States: analysis of national mortality data. American Journal of Hematology, 50, 8490.
  • Tsai, H.-M. (1996) Physiologic cleavage of von Willebrand factor by a plasma protease is dependent on its conformation and requires calcium ion. Blood, 87, 42354244.
  • Tsai, H.-M. & Lian, E.C.-Y. (1998) Antibodies to von Willebrand factor-cleaving protease in acute thrombotic thrombocytopenic purpura. New England Journal of Medicine, 339, 15851594.
  • Tsai, H.-M., Nagel, R.L. & Sussman, I.I. (1991) Subunit composition of plasma von Willebrand factor multimers: evidence for a non-proteolytic mechanism resulting in apparent increase in proteolytic fragments. Thrombosis Research, 63, 179188.
  • Tsai, H.-M., Rice, L., Sarode, R., Chow, T.W. & Moake, J.L. (2000) Antibody inhibitors to von Willebrand factor metalloproteinase and increased binding of von Willebrand factor to platelets in ticlopidine-associated thrombotic thrombocytopenic purpura. Annals of Internal Medicine, 132, 794799.
  • Ubara, Y., Hara, S., Takedatu, H., Katori, H., Yamada, K., Yoshihara, K., Matsushita, Y., Yokoyama, K., Takemoto, F., Yamada, A., Takagawa, R., Endo, Y., Hara, M., Koida, J. & Kumada, H. (1998) Hemolytic uremic syndrome associated with beta-interferon therapy for chronic hepatitis. Nephron, 80, 107108.
  • Ucar, A., Fernandez, H.F., Byrnes, J.J., Lian, E.C. & Harrington, Jr, W.J. (1994) Thrombotic microangiopathy and retroviral infections: a 13-year experience. American Journal of Hematology, 45, 304309.
  • Udvardy, M. & Rak, K. (1990) Cyclophosphamide for chronic relapsing thrombotic thrombocytopenic purpura. Lancet, 336, 15081509.
  • Upshaw, J.D. (1978) Congenital deficiency of a factor in normal plasma that reverses microangiopathic hemolysis and thrombocytopenia. New England Journal of Medicine, 298, 13501352.
  • Van Ojik, H., Biesma, D.W., Fijnheer, R., Hené, R.J. & Lokhurst, H.M. (1997) Cyclosporine for thrombotic thrombocytopenic purpura after autologous bone marrow transplantation. British Journal of Haematology, 96, 641643.
  • Vesely, S.K., George, J.N., Atkinson, B.S. & Raife, T.J. (2000) Thrombotic thrombocytopenic purpura (TTP) versus hemolytic–uremic syndrome (HUS) in adults: analysis of clinical features and outcomes. Blood, 96, 630a.
  • Veyradier, A., Obert, B., Houllier, A., Meyer, D. & Girma, J.-P. (2001) Specific von Willebrand factor-cleaving protease in thrombotic microangiopathies: a study of 111 cases. Blood, 98, 17651772.
  • Wada, H., Mori, Y., Shimura, M., Hiyoyama, K., Ioka, M., Nakasaki, T., Nishikawa, M., Nakano, M., Kumeda, K., Kaneko, T., Nakamura, S. & Shiku, H. (1998) Poor outcome in disseminated intravascular coagulation or thrombotic thrombocytopenic purpura patients with severe vascular endothelial cell injuries. American Journal of Hematology, 58, 189194.
  • Wagoner, R.D., Holley, K.E. & Johnson, W.J. (1968) Accelerated nephrosclerosis and post partum acute renal failure. Quarterly Journal of Medicine, 37, 423435.
  • Waiser, J., Budde, K., Rudolph, B., Orkner, M.A. & Neumayer, H.H. (1999) De novo hemolytic uremic syndorme post renal transplant after cytomegalovirus infection. American Journal of Kidney Diseases, 34, 556559.
  • Walters, M.D., Matthei, I.U., Kay, R., Dillon, M.J. & Barratt, T.M. (1989) The polymorphonuclear leucocyte count in childhood haemolytic uraemic syndrome. Pediatric Nephrology, 3, 130134.
  • Warwicker, P., Goodship, T.H.J., Donne, R.L., Pirson, Y., Nicholls, A., Ward, R.M., Turnpenny, P. & Goodship, J.A. (1998) Genetic studies into inherited and sporadic hemolytic uremic syndrome. Kidney International, 53, 836844.
  • Warwicker, P., Donne, R.L., Goodship, J.A., Goodship, T.H.J., Howie, A.J., Kumararatne, D.S., Thompson, R.A. & Taylor, C.M. (1999) Familial relapsing haemolytic uraemic syndrome and complement factor H deficiency. Nephrology, Dialysis and Transplantation, 14, 12291233.
  • Weiner, C.P. (1987) Thrombotic microangiopathy in pregnancy and the post partum period. Seminars in Hematology, 23, 119129.
  • Welborn, J.L., Emrick, P. & Acevedo, M. (1990) Rapid improvement of thrombotic thrombocytopenic purpura with vincristine and plasmapheresis. American Journal of Hematology, 35, 1821.
  • Wheeler, A.P. & Bernard, G.R. (1999) Treating patients with severe sepsis. New England Journal of Medicine, 340, 207214.
  • White, G.E. & Fujiwara, K. (1986) Expression and intracellular distribution of stress fibres in aortic endothelium. Journal of Cell Biology, 103, 6370.
  • Wilson, W.A., Gharavi, A.E., Koike, T., Lockshin, M.D., Branch, D.W., Piette, J.C., Brey, R., Derksen, R., Harris, E.N., Hughes, G.R., Triplett, D.A. & Khamashta, M.A. (1999) International consensus statement for the preliminary classification criteria for definite antiphospholipid syndrome. Arthritis and Rheumatism, 42, 13091311.
  • Wong, C.S., Jelacic, S., Habeeb, R.L., Watkins, S.L. & Tarr, P.I. (2000) The risk of the hemolytic uremic syndrome after antibiotic treatment of Eschericia coli 0157:H7 infections. New England Journal of Medicine, 342, 19301936.
  • Wurzel, J.M. (1979) TTP lesions in the placenta but not in the fetus. New England Journal of Medicine, 301, 503504.
  • Zeigler, Z.R., Shadduck, R.K., Gryn, J.F., Rintels, P.B., George, J.N., Besa, E.C., Bodensteiner, D., Silver, B., Kramer, R.E. & the North America TTP Group (2001) Cryoprecipitate poor plasma does not improve early response in primary adult thrombotic thrombocytopenic purpura (TTP). Journal of Clinical Apheresis, 16, 1922.
  • Zimmerhacki, L. (2000) E. coli antibiotics and the haemolytic uraemic syndrome. New England Journal of Medicine, 342, 19901991.
  • Zimmerman, T.S., Dent, J.A., Ruggeri, Z.M. & Nannini, L.H. (1986) Subunit composition of plasma von Willebrand factor: cleavage is present in normal individuals, increased in IIA and IIB von Willebrand disease, but minimal in variants with aberrant structure of individual oligomers (types IIC, IID and IIE). Journal of Clinical Investigation, 77, 947951.
  • Zoja, C., Corna, D., Farina, C., Sacchi, G., Lingwood, C., Doyle, M.P., Padhye, V.V., Abbate, M. & Remuzzi, G. (1992) Verotoxin glycoplipid receptors determine the localization of microangiopathic process in rabbits given verotoxin 1. Journal of Laboratory and Clinical Medicine, 120, 229238.