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Allogeneic haematopoietic stem cell transplantation for the treatment of adult T-cell leukaemia/lymphoma

  1. Masahiro Kami1,
  2. Tamae Hamaki1,
  3. Shigesaburo Miyakoshi1,
  4. Naoko Murashige2,
  5. Yoshinobu Kanda2,
  6. Ryuji Tanosaki2,
  7. Yoichi Takaue2,
  8. Shuichi Taniguchi3,
  9. Hisamaru Hirai4,
  10. Keiya Ozawa5,
  11. Masaharu Kasai6

Article first published online: 24 JAN 2003

DOI: 10.1046/j.1365-2141.2003.04054.x

Issue

British Journal of Haematology

British Journal of Haematology

Volume 120, Issue 2, pages 304–309, January 2003

Additional Information

How to Cite

Kami, M., Hamaki, T., Miyakoshi, S., Murashige, N., Kanda, Y., Tanosaki, R., Takaue, Y., Taniguchi, S., Hirai, H., Ozawa, K. and Kasai, M. (2003), Allogeneic haematopoietic stem cell transplantation for the treatment of adult T-cell leukaemia/lymphoma. British Journal of Haematology, 120: 304–309. doi: 10.1046/j.1365-2141.2003.04054.x

Author Information

  1. 1

    Department of Haematology, Toranomon Hospital,

  2. 2

    Stem Cell Transplant Unit, National Cancer Centre Hospital, Tokyo,

  3. 3

    Division of Haematology, Hamano-machi Hospital, Fukuoka,

  4. 4

    Department of Haematology and Oncology, University of Tokyo Hospital, Tokyo,

  5. 5

    Division of Cell Transplantation and Transfusion, Jichi Medical School, Tochigi, and

  6. 6

    Department of Internal Medicine, Sapporo Hokuyu Hospital, Hokkaido, Japan

*Dr Masahiro Kami, Department of Medical Oncology, Haematopoietic Stem Cell Transplantation Unit, National Cancer Centre Hospital, 5-1-1 Tsjukiji, Chuo-ku, Tokyo 104–0045, Japan. E-mail: mkami@ncc.go.jp

Publication History

  1. Issue published online: 24 JAN 2003
  2. Article first published online: 24 JAN 2003
  3. Received 9 August 2002;accepted for publication 12 August 2002

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Keywords:

  • allogeneic haematopoietic stem-cell transplantation;
  • adult T-cell leukaemia/lymphoma;
  • graft-versus-host disease;
  • regimen-related toxicity;
  • graft-versus-leukaemia effect

Summary. The feasibility of allogeneic haematopoietic stem-cell transplantation (allo-HSCT) in 11 patients with adult T-cell leukaemia/lymphoma (ATL) (6 acute, 4 lymphoma, 1 chronic type) was evaluated. The preparative regimens (9 conventional, 2 reduced-intensity) were tolerable. Five patients developed acute graft-versus-host disease (GVHD), and three, extensive chronic GVHD. All 10 patients who survived > 30 d achieved complete remission. Estimated 1-year overall and disease-free survival rates were 53 ± 30% and 45 ± 29% respectively. Four patients remain alive and disease-free at a median follow-up of 25 months. The others died of transplantation-related complications. This pilot study suggests that allo-HSCT in ATL should be evaluated further.

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