SEARCH

SEARCH BY CITATION

REFERENCES

  • Afar, D.E., McLaughlin, J., Sherr, C.J., Witte, O.N. & Roussel, M.F. (1995) Signaling by ABL oncogenes through cyclin D1. Proceedings of the National Academy of Science of the USA, 92, 95409544.
  • Ahuja, H., Bar-Eli, M., Arlin, Z., Advani, S., Allen, S.L., Goldman, J., Snyder, D., Foti, A. & Cline, M. (1991) The spectrum of molecular alterations in the evolution of chronic myelocytic leukemia. Journal of Clinical Investigation, 87, 20422047.
  • Asada, M., Yamada, T., Fukumuro, K. & Mizutani, S. (1998) p21Cip1/WAF1 is important for differentiation and survival of U937 cells. Leukemia, 12, 19441950.
  • Asada, M., Yamada, T., Ichijo, H., Delia, D., Miyazono, K., Fukumuro, K. & Mizutani, S. (1999) Apoptosis inhibitory activity of cytoplasmic p21 (Cip1/WAF1) in monocytic differentiation. EMBO Journal, 18, 12231234.
  • Chen, R., Kim, O., Yang, J., Sato, K., Eisenmann, K.M., McCarthy, J., Chen, H. & Qiu, Y. (2001) Regulation of Akt/PKB activation by tyrosine phosphorylation. Journal of Biological Chemistry, 276, 3185831862.
  • Cheng, M., Olivier, P., Diehl, J.A., Fero, M., Roussel, M.F., Roberts, J.M. & Sherr, C.J. (1999) The p21 (Cip1) and p27 (Kip1) CDK ‘inhibitors’ are essential activators of cyclin d-dependent kinases in murine fibroblasts. EMBO Journal, 18, 15711583.
  • Cortez, D., Reuther, G. & Pendergast, A.M. (1997) The Bcr-Abl tyrosine kinase activates mitogenic signaling pathways and stimulates G1-to-S phase transition in hematopoietic cells. Oncogene, 15, 23332342.
  • Dahia, P.L., Aguiar, R.C., Alberta, J., Kum, J.B., Caron, S., Sill, H., Marsh, D.J., Ritz, J., Freedman, A., Stiles, C. & Eng, C. (1999) PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanisms in haematological malignancies. Human Molecular Genetics, 8, 185193.
  • El-Deiry, W.S. (1998) Regulation of p53 downstream genes. Seminars in Cancer Biology, 8, 345357.
  • El-Deiry, W.S., Tokino, T., Velculescu, V.E., Levy, D.B., Parsons, R., Trent, J.M., Lin, D., Mercer, W.E., Kinzler, K.W. & Vogelstein, B. (1993) WAF1, a potential mediator of p53 tumor suppression. Cell, 75, 817825.
  • El-Deiry, W.S., Harper, J.W., O'Connor, P.M., Velculescu, V.E., Canman, C.E., Jackman, J., Pietenpol, J.A., Burrell, M., Hill, D.E. & Wang, Y . (1994) WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Research, 54, 11691174.
  • Di Bacco, A., Keeshan, K., McKenna, S.L. & Cotter, T.G. (2000) Molecular abnormalities in chronic myeloid leukemia: deregulation of cell growth and apoptosis. Oncologist, 5, 405415.
  • Diehl, J.A., Cheng, M., Roussel, M.F. & Sherr, C.J. (1998) Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. Genes and Development, 12, 34993511.
  • Fujio, Y., Guo, K., Mano, T., Mitsuuchi, Y., Testa, J.R. & Walsh, K. (1999) Cell cycle withdrawal promotes myogenic induction of Akt, a positive modulator of myocyte survival. Molecular and Cellular Biology, 19, 50735082.
  • Gartel, A.L. & Tyner, A.L. (1999) Transcriptional regulation of the p21 (WAF1/CIP1) gene. Experimental Cell Research, 246, 280289.
  • Gesbert, F., Sellers, W.R., Signoretti, S., Loda, M. & Griffin, J.D. (2000) BCR/ABL regulates expression of the cyclin-dependent kinase inhibitor p27Kip1 through the phosphatidylinositol 3-kinase/AKT pathway. Journal of Biological Chemistry, 275, 3922339230.
  • Gorospe, M., Cirielli, C., Wang, X., Seth, P., Capogrossi, M.C. & Holbrook, N.J. (1997) p21 (Waf1/Cip1) protects against p53-mediated apoptosis of human melanoma cells. Oncogene, 14, 929935.
  • Harper, J.W., Adami, G.R., Wei, N., Keyomarsi, K. & Elledge, S.J. (1993) The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell, 75, 805816.
  • Hiyama, H., Iavarone, A., LaBaer, J. & Reeves, S.A. (1997) Regulated ectopic expression of cyclin D1 induces transcriptional activation of the cdk inhibitor p21 gene without altering cell cycle progression. Oncogene, 14, 25332542.
  • Jonuleit, T., Van Der Kuip, H., Miething, C., Michels, H., Hallek, M., Duyster, J. & Aulitzky, W.E. (2000) Bcr-Abl kinase down-regulates cyclin-dependent kinase inhibitor p27 in human and murine cell lines. Blood, 96, 19331939.
  • Kandel, E.S. & Hay, N. (1999) The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Experimental Cell Research, 253, 210229.
  • Keeshan, K., Mills, K.I., Cotter, T.G. & McKenna, S.L. (2001) Elevated Bcr-Abl expression levels are sufficient for a haematopoietic cell line to acquire a drug-resistant phenotype. Leukemia, 15, 18231833.
  • Keeshan, K., Cotter, T.G. & McKenna, S.L. (2002) High Bcr-Abl expression prevents the translocation of Bax and Bad to the mitochondrion. Leukemia, 9, 17251734.
  • Khanna, S.J., Brown, R., Whetton, A.D., Ball, K.L. & Dive, C. (2001) v-Abl protein-tyrosine kinase up-regulates p21WAF-1 in cell cycle arrested and proliferating myeloid cells. Journal of Biological Chemistry, 276, 1114311150.
  • Krasilnikov, M.A. (2000) Phosphatidylinositol-3 kinase dependent pathways: the role in control of cell growth, survival, and malignant transformation. Biochemistry (Moscow), 65, 5967.
  • LaBaer, J., Garrett, M.D., Stevenson, L.F., Slingerland, J.M., Sandhu, C., Chou, H.S., Fattaey, A. & Harlow, E. (1997) New functional activities for the p21 family of CDK inhibitors. Genes and Development, 11, 847862.
  • Lawlor, M.A. & Rotwein, P. (2000) Insulin-like growth factor-mediated muscle cell survival: central roles for Akt and cyclin-dependent kinase inhibitor p21. Molecular and Cellular Biology, 20, 89838995.
  • Lee, M.H., Reynisdottir, I. & Massague, J. (1995) Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution. Genes and Development, 9, 639649.
  • Lowe, S.W. (1999) Activation of p53 by oncogenes. Endocrine-Related Cancer, 6, 4548.
  • Maehama, T. & Dixon, J.E. (1998) The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. Journal of Biological Chemistry, 273, 1337513378.
  • Martin, S.J., Reutelingsperger, C.P., McGahon, A.J., Rader, J.A., Van Schie, R.C., LaFace, D.M. & Green, D.R. (1995) Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. Journal of Experimental Medicine, 182, 15451556.
  • Matsuoka, S., Edwards, M.C., Bai, C., Parker, S., Zhang, P., Baldini, A., Harper, J.W. & Elledge, S.J. (1995) p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene. Genes and Development, 9, 650662.
  • Mitsuuchi, Y., Johnson, S.W., Selvakumaran, M., Williams, S.J., Hamilton, T.C. & Testa, J.R. (2000) The phosphatidylinositol 3-kinase/AKT signal transduction pathway plays a critical role in the expression of p21WAF1/CIP1/SDI1 induced by cisplatin and paclitaxel. Cancer Research, 60, 53905394.
  • Neshat, M.S., Raitano, A.B., Wang, H.G., Reed, J.C. & Sawyers, C.L. (2000) The survival function of the Bcr-Abl oncogene is mediated by Bad-dependent and -independent pathways: roles for phosphatidylinositol 3-kinase and Raf. Molecular and Cellular Biology, 20, 11791186.
  • Poluha, W., Poluha, D.K., Chang, B., Crosbie, N.E., Schonhoff, C.M., Kilpatrick, D.L. & Ross, A.H. (1996) The cyclin-dependent kinase inhibitor p21 (WAF1) is required for survival of differentiating neuroblastoma cells. Molecular and Cellular Biology, 16, 13351341.
  • Polyak, K., Lee, M.H., Erdjument-Bromage, H., Koff, A., Roberts, J.M., Tempst, P. & Massague, J. (1994) Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell, 78, 5966.
  • Ritt, M.G., Mayor, J., Wojcieszyn, J., Smith, R., Barton, C.L. & Modiano, J.F. (2000) Sustained nuclear localization of p21/WAF-1 upon growth arrest induced by contact inhibition. Cancer Letters, 158, 7384.
  • Rossig, L., Jadidi, A.S., Urbich, C., Badorff, C., Zeiher, A.M. & Dimmeler, S. (2001) Akt-dependent phosphorylation of p21 (Cip1) regulates PCNA binding and proliferation of endothelial cells. Molecular and Cellular Biology, 21, 56445657.
  • Sato, N., Mizumoto, K., Maehara, N., Kusumoto, M., Nishio, S., Urashima, T., Ogawa, T. & Tanaka, M. (2000) Enhancement of drug-induced apoptosis by antisense oligodeoxynucleotides targeted against Mdm2 and p21WAF1/CIP1. Anticancer Research, 20, 837842.
  • Scott, M.T., Morrice, N. & Ball, K.L. (2000) Reversible phosphorylation at the C-terminal regulatory domain of p21 (Waf1/Cip1) modulates proliferating cell nuclear antigen binding. Journal of Biological Chemistry, 275, 1152911537.
  • Sherr, C.J. & Roberts, J.M. (1999) CDK inhibitors: positive and negative regulators of G1-phase progression. Genes and Development, 13, 15011512.
  • Skorski, T., Bellacosa, A., Nieborowska-Skorska, M., Majewski, M., Martinez, R., Choi, J.K., Trotta, R., Wlodarski, P., Perrotti, D., Chan, T.O., Wasik, M.A., Tsichlis, P.N. & Calabretta, B. (1997) Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway. EMBO Journal, 16, 61516161.
  • Stambolic, V., Suzuki, A., De La Pompa, J.L., Brothers, G.M., Mirtsos, C., Sasaki, T., Ruland, J., Penninger, J.M., Siderovski, D.P. & Mak, T.W. (1998) Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell, 95, 2939.
  • Steinman, R.A. & Johnson, D.E. (2000) p21WAF1 prevents down-modulation of the apoptotic inhibitor protein c-IAP1 and inhibits leukemic apoptosis. Molecular Medicine, 6, 736749.
  • Sun, H., Lesche, R., Li, D.M., Liliental, J., Zhang, H., Gao, J., Gavrilova, N., Mueller, B., Liu, X. & Wu, H. (1999) PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. Proceedings of the National Academy of Science of the USA, 96, 61996204.
  • Suzuki, A., Tsutomi, Y., Akahane, K., Araki, T. & Miura, M. (1998) Resistance to Fas-mediated apoptosis: activation of caspase 3 is regulated by cell cycle regulator p21WAF1 and IAP gene family ILP. Oncogene, 17, 931939.
  • Toyoshima, H. & Hunter, T. (1994) p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell, 78, 6774.
  • Vazquez, F. & Sellers, W.R. (2000) The PTEN tumor suppressor protein: an antagonist of phosphoinositide 3-kinase signaling. Biochimica et Biophysica Acta, 1470, M21M35.
  • Wang, Z., Van Tuyle, G., Conrad, D., Fisher, P.B., Dent, P. & Grant, S. (1999) Dysregulation of the cyclin-dependent kinase inhibitor p21WAF1/CIP1/MDA6 increases the susceptibility of human leukemia cells (U937) to 1-beta-d-arabinofuranosylcytosine-mediated mitochondrial dysfunction and apoptosis. Cancer Research, 59, 12591267.
  • Zhou, B.P., Liao, Y., Xia, W., Spohn, B., Lee, M.H. & Hung, M.C. (2001) Cytoplasmic localization of p21Cip1/WAF1 byAkt-induced phosphorylation in HER-2/neu-overexpressing cells. Nature Cell Biology, 3, 245252.