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Keywords:

  • Factor VIII;
  • venous thromboembolism;
  • β-adrenoreceptors

Summary. Beta-blockers significantly reduce elevated factor VIII (FVIII) levels in patients with venous thromboembolism (VTE). To determine whether β-adrenergic receptors are important in the aetiology of high FVIII levels, we investigated four coding polymorphisms of the β1- and β2-receptor genes in 64 patients with high FVIII and VTE and 100 healthy controls. Genotypic and allelic frequencies were not significantly different between the patient and control groups. However, a significant dosage effect of the β2 E27 allele on plasma FVIII coagulant activity levels was observed in normal group O individuals.