Bronchial responsiveness to methacholine is increased in citrus red mite (Panonychus citri)-sensitive children without asthmatic symptoms

Authors

  • Min,

    1. *1 Department of Internal Medicine, Seoul National University College of Medicine, Seoul, 2 Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, 3 Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, §4 Department of Paediatrics, Cheju University College of Medicine, Cheju, Korea
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  • * Kim,

    1. *1 Department of Internal Medicine, Seoul National University College of Medicine, Seoul, 2 Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, 3 Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, §4 Department of Paediatrics, Cheju University College of Medicine, Cheju, Korea
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  • * Park,

    1. *1 Department of Internal Medicine, Seoul National University College of Medicine, Seoul, 2 Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, 3 Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, §4 Department of Paediatrics, Cheju University College of Medicine, Cheju, Korea
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  • Lee,

    1. *1 Department of Internal Medicine, Seoul National University College of Medicine, Seoul, 2 Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, 3 Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, §4 Department of Paediatrics, Cheju University College of Medicine, Cheju, Korea
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  • Lee,

    1. *1 Department of Internal Medicine, Seoul National University College of Medicine, Seoul, 2 Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, 3 Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, §4 Department of Paediatrics, Cheju University College of Medicine, Cheju, Korea
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  • * Son,

    1. *1 Department of Internal Medicine, Seoul National University College of Medicine, Seoul, 2 Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, 3 Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, §4 Department of Paediatrics, Cheju University College of Medicine, Cheju, Korea
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  • * Kim,

    1. *1 Department of Internal Medicine, Seoul National University College of Medicine, Seoul, 2 Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, 3 Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, §4 Department of Paediatrics, Cheju University College of Medicine, Cheju, Korea
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  • and * Cho *

    1. *1 Department of Internal Medicine, Seoul National University College of Medicine, Seoul, 2 Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, 3 Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, §4 Department of Paediatrics, Cheju University College of Medicine, Cheju, Korea
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Cho Department of Internal Medicine, Seoul ational University College of Medicine, 28 Yungun-dong Chongno-gu, Seoul 110–744 Korea.

Abstract

Background

A recent investigation has suggested that citrus red mite (Panonychus citri, CRM) is a common sensitizing allergen among children living around citrus farms.

Objective

A cross-sectional survey was performed to evaluate the bronchial responsiveness to methacholine in CRM-sensitive children without asthmatic symptoms.

Subjects and methods

A total of 375 children living around citrus farms were enrolled in this study. There were 201 boys and 174 girls with a mean age of 12.5 (range 7–16) years. Each subject was evaluated by a questionnaire, a skin prick test with 13 common inhalant allergens including CRM, and a methacholine bronchial provocation test (MBPT).

Results

Positive rate of MBPT (PC20-methacholine < 25 mg/mL) was higher in atopic rhinitic and atopic control children than in nonatopic rhinitic and nonatopic control subjects (41.3% and 33.3% vs 17.2% and 15.4%, respectively, both P < 0.05). Slope of dose–response curve (DRS, %/mg/mL) was higher in atopic rhinitic children than in nonatopic rhinitic, atopic control and nonatopic control subjects (14.3 ± 0.87 vs 9.4 ± 0.72, 10.0 ± 1.37 and 9.2 ± 1.51, P < 0.05, respectively). Both the positive rate of MBPT and the DRS were increased in children with positive skin response to CRM than in those without sensitization (48.2% vs 22.9%, P = 0.0001; 15.6 ± 1.26 vs 10.2 ± 0.65, P = 0.0001).

Conclusion

Bronchial responsiveness is increased in citrus red mite-sensitive children even if they have no asthmatic symptoms.

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