Crete: does farming explain urban and rural differences in atopy?
Article first published online: 20 DEC 2001
Clinical & Experimental Allergy
Volume 31, Issue 12, pages 1822–1828, December 2001
How to Cite
Barnes, M., Cullinan, P., Athanasaki, P., MacNeill, S., Hole, A. M., Harris, J., Kalogeraki, S., Chatzinikolaou, M., Drakonakis, N., Bibaki-Liakou, V., Newman Taylor, A. J. and Bibakis, I. (2001), Crete: does farming explain urban and rural differences in atopy?. Clinical & Experimental Allergy, 31: 1822–1828. doi: 10.1046/j.1365-2222.2001.01240.x
- Issue published online: 20 DEC 2001
- Article first published online: 20 DEC 2001
- Submitted 14 December 2000; accepted 3 May 2001.
Background Urban-rural differences in the prevalence of atopy and associated allergic diseases have been reported in several non-European countries. Within Europe, where such variations are less striking, a farm childhood has been postulated to be protective.
Objective We aimed to compare the prevalence of atopy in urban and rural children living in Crete and to examine the role of early exposure to a farming environment in explaining any measured differences.
Methods A cross-sectional survey of children attending secondary schools in Iraklion, the capital city, and five villages 100 km to the south. Atopy was determined by the responses to skin prick tests with seven common aeroallergens.
Results Nine-nundred and ninety-seven children participated in the survey. 19.6% of those living in Iraklion, but only 9.6% of those from the villages, had a positive response to one or more skin prick tests. Among urban children there were significant gradients in the prevalence of atopy across several categories of animal contact and consumption of farm (unpasteurized) milk products – before the age of 5 years. These differences, however, were not apparent among the rural children.