Mattress encasings and mite allergen levels in the Prevention and Incidence of Asthma and Mite Allergy study

Authors

  • R. T. Van Strien,

    1. *Department of Environmental and Occupational Health, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, †Department of Paediatrics, Sophia Children's Hospital, Rotterdam, Departments of ‡Epidemiology and Statistics and §Paediatric Respiratory Medicine, University Hospital Groningen, Groningen, ¶Central Laboratory for the Blood Transfusion Service, Department of Allergy, Amsterdam and **National Institute of Public Health and the Environment, Bilthoven, the Netherlands
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  • L. P. Koopman,

    1. *Department of Environmental and Occupational Health, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, †Department of Paediatrics, Sophia Children's Hospital, Rotterdam, Departments of ‡Epidemiology and Statistics and §Paediatric Respiratory Medicine, University Hospital Groningen, Groningen, ¶Central Laboratory for the Blood Transfusion Service, Department of Allergy, Amsterdam and **National Institute of Public Health and the Environment, Bilthoven, the Netherlands
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  • M. Kerkhof,

    1. *Department of Environmental and Occupational Health, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, †Department of Paediatrics, Sophia Children's Hospital, Rotterdam, Departments of ‡Epidemiology and Statistics and §Paediatric Respiratory Medicine, University Hospital Groningen, Groningen, ¶Central Laboratory for the Blood Transfusion Service, Department of Allergy, Amsterdam and **National Institute of Public Health and the Environment, Bilthoven, the Netherlands
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  • M. Oldenwening,

    1. *Department of Environmental and Occupational Health, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, †Department of Paediatrics, Sophia Children's Hospital, Rotterdam, Departments of ‡Epidemiology and Statistics and §Paediatric Respiratory Medicine, University Hospital Groningen, Groningen, ¶Central Laboratory for the Blood Transfusion Service, Department of Allergy, Amsterdam and **National Institute of Public Health and the Environment, Bilthoven, the Netherlands
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  • J. C. De Jongste,

    1. *Department of Environmental and Occupational Health, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, †Department of Paediatrics, Sophia Children's Hospital, Rotterdam, Departments of ‡Epidemiology and Statistics and §Paediatric Respiratory Medicine, University Hospital Groningen, Groningen, ¶Central Laboratory for the Blood Transfusion Service, Department of Allergy, Amsterdam and **National Institute of Public Health and the Environment, Bilthoven, the Netherlands
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  • J. Gerritsen,

    1. *Department of Environmental and Occupational Health, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, †Department of Paediatrics, Sophia Children's Hospital, Rotterdam, Departments of ‡Epidemiology and Statistics and §Paediatric Respiratory Medicine, University Hospital Groningen, Groningen, ¶Central Laboratory for the Blood Transfusion Service, Department of Allergy, Amsterdam and **National Institute of Public Health and the Environment, Bilthoven, the Netherlands
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  • H. J. Neijens,

    1. *Department of Environmental and Occupational Health, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, †Department of Paediatrics, Sophia Children's Hospital, Rotterdam, Departments of ‡Epidemiology and Statistics and §Paediatric Respiratory Medicine, University Hospital Groningen, Groningen, ¶Central Laboratory for the Blood Transfusion Service, Department of Allergy, Amsterdam and **National Institute of Public Health and the Environment, Bilthoven, the Netherlands
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  • R. C. Aalberse,

    1. *Department of Environmental and Occupational Health, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, †Department of Paediatrics, Sophia Children's Hospital, Rotterdam, Departments of ‡Epidemiology and Statistics and §Paediatric Respiratory Medicine, University Hospital Groningen, Groningen, ¶Central Laboratory for the Blood Transfusion Service, Department of Allergy, Amsterdam and **National Institute of Public Health and the Environment, Bilthoven, the Netherlands
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  • H. A. Smit,

    1. *Department of Environmental and Occupational Health, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, †Department of Paediatrics, Sophia Children's Hospital, Rotterdam, Departments of ‡Epidemiology and Statistics and §Paediatric Respiratory Medicine, University Hospital Groningen, Groningen, ¶Central Laboratory for the Blood Transfusion Service, Department of Allergy, Amsterdam and **National Institute of Public Health and the Environment, Bilthoven, the Netherlands
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  • B. Brunekreef

    1. *Department of Environmental and Occupational Health, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, †Department of Paediatrics, Sophia Children's Hospital, Rotterdam, Departments of ‡Epidemiology and Statistics and §Paediatric Respiratory Medicine, University Hospital Groningen, Groningen, ¶Central Laboratory for the Blood Transfusion Service, Department of Allergy, Amsterdam and **National Institute of Public Health and the Environment, Bilthoven, the Netherlands
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B. Brunekreef, IRAS-EOH, PO Box 80176, 3508 TD Utrecht, the Netherlands. Tel. + 31 30 2535400, Fax: + 31 30 2535077. E-mail: b.brunekreef@iras.uu.nl

Summary

Background Reduction of allergen exposure from birth may reduce sensitization and subsequent allergic disease.

Objective To measure the influence of mite allergen-impermeable mattress encasings and cotton placebo encasings on the amount of dust and mite allergen in beds.

Methods A total of 810 children with allergic mothers took part in the Prevention and Incidence of Asthma and Mite Allergy (PIAMA) study. Allergen-impermeable and placebo mattress encasings were applied to the childrens' and the parents' beds before birth. Dust samples were taken from the beds of children and their parents before birth and 3 and 12 months after birth. Extracts of dust samples were analysed for mite allergens (Der p 1 and Der f 1).

Results Active mattress encasings were significantly more effective in reducing dust and mite allergen levels than placebo encasings. Mite allergen levels were low in general and the treatment effect was modest. Twelve months after birth, mattresses with active mattress encasings had about half the amount of Der 1 (Der p 1 + Der f 1)/m2, compared to mattresses with placebo encasings, for the child's and the parental mattress.

Conclusion This study shows that mite-impermeable mattress encasings have a significant but modest effect on dust and mite allergen levels of mattresses with low initial mite allergen levels, compared to placebo.

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