Air filtration units in homes with cats: can they reduce personal exposure to cat allergen?
Article first published online: 10 JUN 2003
Clinical & Experimental Allergy
Volume 33, Issue 6, pages 765–769, June 2003
How to Cite
Gore, R. B., Bishop, S., Durrell, B., Curbishley, L., Woodcock, A. and Custovic, A. (2003), Air filtration units in homes with cats: can they reduce personal exposure to cat allergen?. Clinical & Experimental Allergy, 33: 765–769. doi: 10.1046/j.1365-2222.2003.01678.x
- Issue published online: 10 JUN 2003
- Article first published online: 10 JUN 2003
- Submitted 24 October 2002; revised 30 December 2002; accepted 20 January 2003
- air filtration;
- cat allergen;
- environmental control;
- Fel d 1;
- nasal sampling
Background Domestic air filtration units have previously been shown to cause a dramatic fall in airborne pet allergen levels in homes with pets. Clinical trials of air filtration units, however, have failed to reveal a significant beneficial effect. Personal pet allergen exposure during air filtration unit use has never been measured.
Objective To determine the effect of air filtration on inhaled cat allergen exposure in homes with cats.
Methods Nasal air samplers were worn to measure personal cat allergen exposure. The study was carried out in five homes with cats on 4 separate days examining four experimental conditions (cat absent or present, air filtration off or on). The two operators collected four baseline samples and two 15-min samples/h over three consecutive hours. Cat allergen-bearing particles were detected by immunoblotting and allergen concentrations measured by amplified enzyme-linked immunosorbent assay (ELISA).
Results There was a significant reduction in the quantity of the inhaled Fel d 1 when the air cleaner was used with the cat in the room. Fel d 1 halo counts (detransformed means) were 29.3 at baseline, 11.8 after 1 h, 10.0 after 2 h and 14.1 after 3 h, with no change on control days (P = 1.00). With the cat elsewhere in the house, a marginal, but statistically significant reduction was observed only after 3 h with the use of air cleaner (Fel d 1 halo count: baseline 12.4; 3 h 5.5; P = 0.01).
Conclusions The use of air filtration units appears to result in a much smaller reduction of inhaled cat allergen exposure than suggested by previous studies using standard air samplers. Cat removal remains the best advice to cat-allergic patients who experience symptoms upon exposure.