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Serum antibodies to HIV-1 are produced post-measles virus infection: evidence for cross-reactivity with HLA

  1. Baskar1,
  2. Collins1,
  3. Dorsey-Cooper1,
  4. Pyle1,
  5. Nagel1,
  6. Dwyer2,
  7. Dunston3,
  8. Johnson4,
  9. Kendig1,
  10. Israel2,
  11. Nalin5,
  12. Adler1

Article first published online: 25 DEC 2001

DOI: 10.1046/j.1365-2249.1998.00488.x

Issue

Clinical & Experimental Immunology

Clinical & Experimental Immunology

Volume 111, Issue 2, pages 251–256, February 1998

Additional Information

How to Cite

Baskar, Collins, Dorsey-Cooper, Pyle, Nagel, Dwyer, Dunston, Johnson, Kendig, Israel, Nalin and Adler (1998), Serum antibodies to HIV-1 are produced post-measles virus infection: evidence for cross-reactivity with HLA. Clinical & Experimental Immunology, 111: 251–256. doi: 10.1046/j.1365-2249.1998.00488.x

Author Information

  1. 1

    Laboratory of Immunology, National Institute on Aging, NIH,

  2. 2

    Maryland State Health Department, Baltimore, MD,

  3. 3

    Howard University School of Medicine, Washington, DC,

  4. 4

    Case Western Reserve University School of Medicine, Cleveland OH,

  5. 5

    Merck Research Laboratories, West Point, PA, USA

* PadmaBaskar PhD Laboratory of Immunology, National Institute on Aging, NIH, 4940 Eastern Avenue, Baltimore, MD 21224, USA.

Publication History

  1. Issue published online: 25 DEC 2001
  2. Article first published online: 25 DEC 2001

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Keywords:

  • HIV-1;
  • measles;
  • indeterminate Western blot

Convalescent sera obtained from patients who were recently recovered from an acute measles virus infection were tested for the presence of anti-HIV-1 antibodies by Western blot analysis. While 16% (17/104) of control sera displayed reactive bands to a variety of HIV proteins, 62% (45/73) of convalescent sera demonstrated immunoreactive bands corresponding to HIV-1 Pol and Gag, but not Env antigens. This cross-reactivity appears to be the result of an active measles infection. No HIV-1 immunoblot reactivity (0/10) was observed in sera obtained from young adults several weeks after a combined measles, mumps, and rubella (MMR) vaccination. Interestingly, examination of anti-HLA typing sera specific for either class I and class II molecules revealed that 46% (19/41) of these sera contained cross-reactive antibodies to HIV-1 proteins. Absorption of measles sera with mixed lymphocyte reaction (MLR)-activated lymphocytes and/or HIV-1 recombinant proteins significantly decreased or removed the presence of these HIV-1-immunoreactive antibodies. Together, these findings suggest that the immune response to a natural measles virus infection results in the production of antibodies to HIV-1 and possibly autoantigens.

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