• 1
    Thom D, Grayston J, Siscovick D, Wang S, Weiss N, Daling J. Association of prior infection with Chlamydia pneumoniae and angiographically demonstrated coronary artery disease. JAMA 1992; 268:68 72.
  • 2
    Melnick S, Sharar E, Folsom A, Grayston J, Sorlie P, Wang S, Szklo M. Past infection with Chlamydia pneumoniae strain TWAR and asymptomatic carotid atherosclerosis. Am J Med 1993; 95:499 504.
  • 3
    Patel P, Mendall M, Carrington D, Strachan D, Leatham E, Molineaux N, Levy J. Association of Helicobacter pylori and Chlamydia pneumoniae infections with coronary heart disease and cardiovascular risk factors. Brit Med J 1995; 311:711 4.
  • 4
    Kuo C, Shor A, Campbell L, Fukushi H, Patton D, Grayston J. Demonstration of Chlamydia pneumoniae in atherosclerotic lesions of coronary arteries. J Infect Dis 1993; 167:841 9.
  • 5
    Kuo C, Grayston J, Campbell L, Goo Y, Wissler R, Benditt E. Chlamydia pneumoniae (TWAR) in coronary arteries of young adults (15–34 years old) . Proc Natl Acad Sci USA 1995; 92:6911 4.
  • 6
    Blasi F, Denti F, Erba M et al. Detection of Chlamydia pneumoniae but not Helicobacter pylori in atherosclerotic plaques of aortic aneurysms. J Clin Microbiol 1996; 34:2766 9.
  • 7
    Jackson LA, Campbell LA, Kuo CC, Rodriguez DI, Lee A, Grayston JT. Isolation of Chlamydia pneumoniae from a carotid endarterectomy specimen. J Infect Dis 1997; 176:292 5.
  • 8
    Ramirez JA, Ahkee S, Summersgill JT et al. Isolation of Chlamydia pneumoniae from the coronary artery of a patient with coronary atherosclerosis. Ann Intern Med 1996; 125:979 82.
  • 9
    Fryer RH, Schwobe EP, Woods ML, Rodgers GM. Chlamydia species infect human vascular endothelial cells and induce procoagulant activity. J Invest Med 1997; 45:168 74.
  • 10
    Kaukorantatolvanen SSE, Teppo AM, Laitinen K, Saikku P, Linnavuori K, Leinonen M. Growth of Chlamydia pneumoniae in cultured human peripheral blood mononuclear cells and induction of a cytokine response. Microb Pathog 1996; 21:215 21.
  • 11
    Gaydos C, Summersgill J, Sahney N, Ramirez J, Quinn T. Replication of Chlamydia pneumoniae in vitro in human macrophages, endothelial cells and aortic artery smooth muscle cells. Infect Immun 1996; 64:1614 20.
  • 12
    Knoebel E, Vijayagopal P, Figueroa JE, Martin DH. In vitro infection of smooth muscle cells by Chlamydia pneumoniae. Infect Immun 1997; 65:503 6.
  • 13
    Kalayoglu MV & Byrne GI. Induction of macrophage foam cell formation by Chlamydia pneumoniae. J Infect Dis 1998; 177:725 9.
  • 14
    Muhlestein JB, Anderson JL, Hammond EH, Zhao LP, Trehan S, Schwobe EP, Carlquist JF. Infection with Chlamydia pneumoniae accelerates the development of atherosclerosis and treatment with azithromycin prevents it in a rabbit model. Circulation 1998; 97:633 6.
  • 15
    Laitinen K, Laurila A, Pyhala L, Leinonen M, Saikku P. Chlamydia pneumoniae infection induces inflammatory changes in the aortas of rabbits. Infect Immun 1997; 65:4832 5.
  • 16
    Capron L. Chlamydia in coronary plaques—hidden culprit or harmless hobo? Nature Med 1996; 2:856 7.
  • 17
    Johansson M, Schon K, Ward M, Lycke N. Studies in knockout mice reveal that anti-chlamydial protection requires TH1 cells producing IFN-gamma: is this true for humans? Scand J Immunol 1997; 46:546 52.
  • 18
    Hassell AB, Reynolds DJ, Deacon M, Gaston JSH, Pearce JH. Identification of T-cell stimulatory antigens of Chlamydia trachomatis using synovial fluid-derived T-cell clones. Immunology 1993; 79:513 9.
  • 19
    Halme S, Vonhertzen L, Bloigu A, Kaprio J, Koskenvuo M, Leinonen M, Saikku P, Surcel HM. Chlamydia pneumoniae-specific cell-mediated and humoral immunity in healthy people . Scand J Immunol 1998; 47:517 20.
  • 20
    Mach F, Schonbeck U, Sukhova GK, Atkinson E, Libby P. Reduction of atherosclerosis in mice by inhibition of CD40 signalling. Nature 1998; 394:200 3.
  • 21
    Stemme S, Faber B, Holm J, Wiklund O, Witztum J, Hansson G. T lymphocytes from human atherosclerotic plaques recognize oxidised low density lipoprotein. Proc Natl Acad Sci USA 1995; 92:3893 7.
  • 22
    Xu Q, Dietrich H, Steiner H, Gown A, Schoel B, Mikuz G, Kaufmann S, Wick G. Induction of arteriosclerosis in normocholesterolemic rabbits by immunization with heat shock protein 65. Arterioscler Thromb 1992; 12:789.
  • 23
    Wick G, Schett G, Amberger A, Kleindienst R, Xu QB. Is atherosclerosis an immunologically mediated disease? Immunol Today 1995; 16:27 33.
  • 24
    Kuo C-C, Wang S-P, Grayston J. Growth of trachoma organism in HeLa 229 cell culture,. In: HobsonD, HolmesK, eds. Nongonococcal urethritis and related infections. Washington DC: American Society for Microbiology, 1977: 328 36.
  • 25
    Jonasson L, Holm J, Skalli O, Bondjers G, Hansson G. Regional accumulations of T cells, macrophages, and smooth muscle cells in the human atherosclerotic plaque. Arteriosclerosis 1985; 6:131 8.
  • 26
    Viner N, Bailey L, Life P, Bacon P, Gaston J. Isolation of Yersinia specific T cell clones from the synovial membrane and synovial fluid of a patient with reactive arthritis. Arthritis Rheum 1991; 34:1151 7.
  • 27
    Deane K, Jecock R, Pearce J, Gaston J. Identification and characterization of a DR4-restricted T cell epitope within chlamydia hsp60. Clin Exp Immunol 1997; 109:439 45.
  • 28
    Stemme S, Rymo L, Hansson G. Polyclonal origin of T lymphocytes in human atherosclerotic plaques. Lab Invest 1991; 65:654 9.
  • 29
    Halme S, Juvonen T, Laurila A, Morosin M, Saikku P, Surcel H-M. Chlamydia pneumoniae reactive T lymphocytes in the walls of abdominalaortic aneurysms. Eur J Clin Invest 1999; 29:546 52.
  • 30
    Pitzalis C, Kingsley G, Covelli M, Meliconi R, Markey A, Panayi G. Selective migration of the human helper-inducer memory T cell subset—confirmation by in vivo cellular kinetic studies. Eur J Immunol 1991; 21:369 76.
  • 31
    Galea P, Brezinschek R, Lipsky P, Oppenheimer-Marks N. Phenotypic characterization of CD4-/αβ TCR+ and γδ TCR+ T cells with a transendothelial migratory capacity. J Immunol 1994; 153:529 41.
  • 32
    Oksenberg JR, Stavri GT, Jeong MC, Garovoy N, Salisbury JR, Erusalimsky JD. Analysis of the T-cell receptor repertoire in human atherosclerosis. Cardiovasc Res 1997; 36:256 67.
  • 33
    Bieganowska KD, Ausubel LJ, Modabber Y, Slovik E, Messersmith W, Hafler DA. Direct ex vivo analysis of activated, Fas-sensitive autoreactive T cells in human autoimmune disease. J Exp Med 1997; 185:1585 94.
  • 34
    Gaston JSH. Heat shock proteins and arthritis—new readers start here. Autoimmunity 1997; 26:33 42.
  • 35
    Van Eden W, Hogervorst E, Wauben M, VanderZee R, Boog C. Heat shock proteins as antigens in autoimmunity. Biochem Soc Trans 1991; 19:171 5.
  • 36
    Xu QB, Willeit J, Marosi M et al. Association of serum antibodies to heat-shock protein-65 with carotid atherosclerosis. Lancet 1993; 341:255 9.
  • 37
    Xu Q & Wick G. Stress proteins in atherogenesis. In: Van EdenW, YoungD, eds. Stress proteins in medicine. New York: Marcel Dekker, 1996: 445 64.
  • 38
    Xu Q, Kleindienst R, Waitz W, Dietrich H, Wick G. Increased expression of heat shock protein 65 coincides with a population of infiltrating T lymphocytes in atherosclerotic lesions in rabbits specifically responding to heat shock protein 65. J Clin Invest 1993; 91:2693.
  • 39
    Xu QB, Kleindienst R, Schett G, Waitz W, Jindal S, Gupta RS, Dietrich H, Wick G. Regression of arteriosclerotic lesions induced by immunization with heat shock protein 65-containing material in normocholesterolemic, but not hypercholesterolemic, rabbits. Atherosclerosis 1996; 123:145 55.
  • 40
    Kol A, Sukhova GK, Lichtman AH, Libby P. Chlamydial heat shock protein localises in human atheroma and regulates macrophage tumour necrosis factor-alpha and matrix metalloproteinase expression. Circulation 1998; 98:300 7.
  • 41
    Bachmeier K, Neu N, DelaMaza L, Pal S, Hessel A, Penninger J. Chlamydia infections and heart disease linked through antigenic mimicry. Science 1999; 283:1335 9.