• 1
    Lieberman JS & Kane GC. Asthma mortality: the worldwide response. J Royal Soc Med 1997; 89:265 7.
  • 2
    Johnston SL, Pattemore PK, Sanderson G et al. The relationship between upper respiratory infections and hospital admissions for asthma: a time trend analysis. Am J Respir Crit Care Med 1996; 154:654 60.
  • 3
    Johnston SL, Pattemore PK, Sanderson G et al. Community study of role of viral infections in exacerbations of asthma in 9–11 year old children. BMJ 1995; 310:1225 9.
  • 4
    Nicholson KG, Kent J, Ireland DC. Respiratory viruses and exacerbation of asthma in adults. BMJ 1993; 307:982 6.
  • 5
    Chanarin N, Miles J, Beasley R, Holgate ST, Johnston SL. Seasonal distribution of episodes of acute severe asthma in adults. Thorax 1997; 52 (Suppl. 6):S28.
  • 6
    Fraenkel DG, Bardin PG, Sanderson G, Lampe F, Johnston SL, Holgate ST. Lower airway inflammation during rhinovirus colds in normal and in asthmatic subjects. Am J Respir Crit Care Med 1995; 151:879 86.
  • 7
    Lemanske RF, Dick EC, Swenson CA, Vrtis RF, Busse WW. Rhinovirus upper respiratory infection increases airway hyper-reactivity and late asthmatic reactions. J Clin Invest 1989; 83:1 10.
  • 8
    Calhoun WJ, Dick EC, Schwartz LB, Busse WW. A common cold virus rhinovirus 16 potentiates airway inflammation after segmental bronchoprovocation in allergic subjects. J Clin Invest 1994; 94:2200 8.
  • 9
    Gern JE & Busse WW. Association of rhinovirus infections with asthma. Clin Microbiol Rev 1999; 12:9 18.
  • 10
    Sethi SK, Bianco A, Allen JT, Knight RA, Spiteri MA. Interferon-gamma (IFN-γ) down-regulates the rhinovirus-induced expression of intercellular adhesion molecule-1 (ICAM-1) on human airway epithelial cells. Clin Exp Immunol 1997; 110:362 9.
  • 11
    Papi A & Johnston SL. Rhinovirus infection induces expression of its own receptor intercellular adhesion molecule 1 (ICAM-1) via increased NF-κB-mediated transcription. J Biol Chem 1999; 274:9707 20.
  • 12
    Hakonarson HA. Mechanisms of rhinovirus induced changes in airway smooth muscle responsiveness. J Clin Invest 1998; 102:1732 41.
  • 13
    Bianco A, Sethi SK, Allen JT, Knight RA, Spiteri MA. Th2 cytokines exert a dominant influence on epithelial cell expression of the major group human rhinovirus receptor, ICAM-1. Eur Respir J 1998; 12:619 26.
  • 14
    Schleimer RP & Bochner BS. The role of adhesion molecules in allergic inflammation and their suitability as antiallergic therapy. Clin Exp Allergy 1998; 28 (Suppl. 3):15 23.
  • 15
    Briode DH, Sullivan S, Gifford T, Sriramarao P. Inhibition of pulmonary eosinophilia in P-selectin and ICAM-1 deficient mice. Am J Respir Cell Mol Biol 1998; 18:218 25.
  • 16
    Chin JE, Winterrowd GE, Hatfield CA et al. Involvement of intercellular adhesion molecule in the antigen induced infiltration of eosinophils and lymphocytes into the airways of a murine model of pulmonary inflammation. Am J Respir Cell Mol Biol 1998; 18:158 67.
  • 17
    Sharon RF, Grunberg K, Van Krieekn JHJM et al. Experimental rhinovirus (RV)16 infection enhances ICAM-1 expression in bronchial mucosal biopsies of mildly asthmatic subjects, regardless of inhaled steroid treatment. Am J Respir Crit Care Med 1998; 157:A22.
  • 18
    Bardin PGM, Fraenkel DJ, Sanderson G, Dorwood M, Lau LCK, Johnston SL, Holgate ST. Amplified rhinovirus colds in atopic subjects. Clin Exp Allergy 1994; 25:457 64.
  • 19
    Hamilos DL, Leung DY, Wood R, Cunningham L, Bean DK, Yasrnel Z, Schotman E, Hamid Q. Evidence of distinct cytokine expression in allergic versus nonallergic chronic sinusitis. J Allergy Clin Immunol 1995; 96:5537 44.
  • 20
    Hamelmann E, Wahn U, Gelfand EW. Role of Th-2 cytokines in the development of allergen induced airway inflammation and hyper-responsiveness. Int Arch Allergy Immunol 1999; 118:90 94.
  • 21
    Chanez P, Vignola AM, Lacoste P, Michel FB, Godard P, Boquet J. Increased expression of adhesion molecules (ICAM-1 and LFA-1) in alveolar macrophages from asthmatic patients. Allergy 1993; 48:576 80.
  • 22
    Wu J, Yankaskas E, Cheng E, Knowles MR, Boucher R. Growth and differentiation of human nasal epithelial cells in culture. Am Rev Respir Dis 1985; 132:311 20.
  • 23
    Xaubet A, Mullol J, Lopez E, Roca-Ferrer J, Rozman M, Carrion T, Fabrat M, Picado C. Comparison of the role of nasal polyp and normal nasal mucosal epithelia cells on in vitro eosinophil survival. Mediation by GM-CSF and inhibition by dexamethasone. Clin Exp Allergy 1994; 24:307 17.
  • 24
    Hsi ED & Remick DG. Monocytes are the major producers if Interleukin-1β in an ex vivo model of local cytokine production. J Interferon Cytokine Res 1995; 15:89 94.
  • 25
    Boenisch T. Staining methods. In: NaishS, ed. Immunochemical staining methods. Glostrup: Dako Corporation, 1989: 13 18.
  • 26
    Spiteri MA, Clarke SW, Poulter LW. Alveolar macrophages that suppress T-cell responses may be crucial to the pathogenetic outcome of pulmonary sarcoidosis. Eur Respir J 1992; 5:394 403.
  • 27
    Mason DY, Abdulaziz Z, Falini B, Stein H. Double immunoenzymatic labelling. In: PolakJ, Van NoordenS, WrightJ, eds. Immunocytochemistry: practical applications in pathology and biology, 2nd edn. Bristol: PSG Publishing Co., 1983: 113 28.
  • 28
    Gern JE, Dick EC, Lee WM, Murray S, Meyer K, Handzel ZT, Busse WW. Rhinovirus enters but does not replicate inside monocytes and airway macrophages. J Immunol 1996; 156:621 7.
  • 29
    SPSS, Version 7 for Windows 95. Seattle: Microsoft.
  • 30
    Hamilos DL, Leung DY, Huston DP, Kamil A, Wood R, Hamid Q. GM-CSF, IL-5, and RANTES immunoreactivity and mRNA expression in chronic hyperplastic sinusitis with nasal polyposis (NP) Clin Exp Allergy 1998; 28:1145 52.
  • 31
    Schall TJ & Bacon KB. Chemokines leukocyte trafficking and inflammation. Curr Opin Immunol 1994; 6:856 73.
  • 32
    Demoly P, Sahla M, Campbell AM, Bousquet J, Crampette C. ICAM-1 expression in upper respiratory mucosa is differentially related to eosinophil and neutrophil inflammation according to the allergic status. Clin Exp Allergy 1998; 28:731 8.
  • 33
    Jankowski JA. Eosinophils in the pathophysiology of nasal polyposis. Acta Otolaryngol (Stokh) 1996; 116:160 3.
  • 34
    Larsen L. The clinical relationship of nasal polyps to asthma. Allergy Asthma Proc 1996; 17:243 9.
  • 35
    Fleming HE, Little FF, Schurr D, Avila PC, Wong H, Liu J, Yagi S, Boushey HA. Rhinovirus 16 colds in healthy and in asthmatic subjects. Similar changes in upper and lower airways. Am J Respir Crit Care Med 1999; 160:100 8.