• 1
    De Smedt D, Menu E, Chaouat G. Immunoactive products of placenta. VI. Induction of transient murine T cell anergy by a low-molecular-weight compound obtained from supernatants of human placental cultures. Cell Immunol 1997; 175:12840.DOI: 10.1006/cimm.1996.1029
  • 2
    Medawar PB. Some immunological and endocrinological problems raised by the evolution of viviparity in vertebrates. Symp Soc Exp Biol 1953; 7:32038.
  • 3
    Tafuri A, Alferink J, Moller P, Hammerling GJ, Arnold B. T cell awareness of paternal alloantigens during pregnancy. Science 1995; 270:6303.
  • 4
    Wegmann TG, Lin H, Guilbert L, Mosmann TR. Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon? Immunol Today 1993; 14:3536.
  • 5
    Marzi M, Vigano A, Trabattoni D et al. Characterization of type 1 and type 2 cytokine production profile in physiologic and pathologic human pregnancy. Clin Exp Immunol 1996; 106:12733.
  • 6
    Raghupathy R. Th1-type immunity is incompatible with successful pregnancy. Immunol Today 1997; 18:47882.
  • 7
    Arck PC, Ferrick DA, Steele-Norwood D et al. Murine T cell determination of pregnancy outcome. Cell Immunol 1999; 196:719.
  • 8
    Saito S, Sakai M, Sasaki Y, Tanebe K, Tsuda H, Michimata T. Quantitative analysis of peripheral blood Th0, Th1, Th2 and the Th1 : Th2 cell ratio during normal human pregnancy and preeclampsia. Clin Exp Immunol 1999; 117:5505.
  • 9
    Hunt JS, Petroff MG, Burnett TG. Uterine leukocytes: key players in pregnancy. Semin Cell Dev Biol 2000; 11:12737.
  • 10
    Vince GS, Johnson PM. Leucocyte populations and cytokine regulation in human uteroplacental tissues. Biochem Soc Trans 2000; 28:1915.
  • 11
    Munn DH, Zhou M, Attwood JT et al. Prevention of allogeneic fetal rejection by tryptophan catabolism. Science 1998; 281:11913.
  • 12
    Piccinni MP, Giudizi MG, Biagiotti R et al. Progesterone favors the development of human T helper cells producing Th2-type cytokines and promotes both IL-4 production and membrane CD30 expression in established Th1 cell clones. J Immunol 1995; 155:12833.
  • 13
    Szekeres-Bartho J, Wegmann TG. A progesterone-dependent immunomodulatory protein alters the Th1/Th2 balance. J Reprod Immunol 1996; 31:8195.
  • 14
    Parhar RS, Kennedy TG, Lala PK. Suppression of lymphocyte alloreactivity by early gestational human decidua. I. Characterization of suppressor cells and suppressor molecules. Cell Immunol 1988; 116:392410.
  • 15
    Lala PK, Kennedy TG, Parhar RS. Suppression of lymphocyte alloreactivity by early gestational human decidua. II. Characterization of the suppressor mechanisms. Cell Immunol 1988; 116:41122.
  • 16
    Krause DS, Deutsch C. Cyclic AMP directly inhibits IL-2 receptor expression in human T cells: expression of both p55 and p75 subunits is affected. J Immunol 1991; 146:228596.
  • 17
    Anastassiou ED, Paliogianni F, Balow JP, Yamada H, Boumpas DT. Prostaglandin E2 and other cyclic AMP-elevating agents modulate IL-2 and IL-2Ra gene expression at multiple levels. J Immunol 1992; 148:284552.
  • 18
    Mannie MD, Prevost KD, Marinakis CA. Prostaglandin E2 promotes the induction of anergy during T helper cell recognition of myelin basic protein. Cell Immunol 1995; 160:1328.
  • 19
    Elliott LH, Levay AK. Costimulation with dexamethasone and prostaglandin E2: a novel paradigm for the induction of T-cell anergy. Cell Immunol 1997; 180:12431.
  • 20
    Snijdewint FG, Kalinski P, Wierenga EA, Bos JD, Kapsenberg ML. Prostaglandin E2 differentially modulates cytokine secretion profiles of human T helper lymphocytes. J Immunol 1993; 150:53219.
  • 21
    Kalinski P, Hilkens CM, Snijders A, Snijdewint FG, Kapsenberg ML. IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells. J Immunol 1997; 159:2835.
  • 22
    Kalinski P, Schuitemaker JH, Hilkens CM, Wierenga EA, Kapsenberg ML. Final maturation of dendritic cells is associated with impaired responsiveness to IFN-γ and to bacterial IL-12 inducers: decreased ability of mature dendritic cells to produce IL-12 during the interaction with Th cells. J Immunol 1999; 162:32316.
  • 23
    Rieser C, Bock G, Klocker H, Bartsch G, Thurnher M. Prostaglandin E2 and tumor necrosis factor α cooperate to activate human dendritic cells: synergistic activation of interleukin 12 production. J Exp Med 1997; 186:16038.
  • 24
    Cahill J, Hopper KE. Immunoregulation by macrophages. III. Prostaglandin E suppresses lymphocyte activation but not macro-phage effector function during Salmonella enteritidis infection. Int J Immunopharmacol 1984; 6:917.
  • 25
    Betz M, Fox BS. Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lymphokines. J Immunol 1991; 146:10813.
  • 26
    Paliogianni F, Boumpas DT. Prostaglandin E2 inhibits the nuclear transcription of the human interleukin 2, but not the IL-4, gene in human T cells by targeting transcription factors AP-1 and NF-AT. Cell Immunol 1996; 171:95101.DOI: 10.1006/cimm.1996.0178
  • 27
    Menu E, Kaplan L, Andreu G, Denver L, Chaouat G. Immunoactive products of human placenta. I. An immunoregulatory factor obtained from explant cultures of human placenta inhibits CTL generation and cytotoxic effector activity. Cell Immunol 1989; 119:34152.
  • 28
    Krishnan L, Menu E, Chaouat G, Talwar GP, Raghupathy R. In vitro and in vivo immunosuppressive effects of supernatants from human choriocarcinoma cell lines. Cell Immunol 1991; 138:31325.
  • 29
    Krishnan L, Kinsky R, Chaouat G, Talwar GP, Raghupathy R. Suppression of local and systemic GVHR by supernatants from human choriocarcinoma cell lines. Cell Immunol 1993; 150:37681.DOI: 10.1006/cimm.1993.1205
  • 30
    Chaouat G. Regulation of T-cell activities at the feto–placental interface – by placenta? Am J Reprod Immunol 1999; 42:199204.
  • 31
    Machwate M, Harada S, Leu CT et al. Prostaglandin receptor EP4 mediates the bone anabolic effects of PGE2. Mol Pharmacol 2001; 60:3641.
  • 32
    Matsumoto H, Naraba H, Murakami M et al. Concordant induction of prostaglandin E2 synthase with cyclooxygenase-2 leads to preferred production of prostaglandin E2 over thromboxane and prostaglandin D2 in lipopolysaccharide-stimulated rat peritoneal macrophages. Biochem Biophys Res Commun 1997; 230:1104.DOI: 10.1006/bbrc.1996.5894
  • 33
    Narumiya S, Sugimoto Y, Ushikubi F. Prostanoid receptors: structures, properties, and functions. Physiol Rev 1999; 79:1193226.
  • 34
    Bauman GP, Bartik MM, Brooks WH, Roszman TL. Induction of cAMP-dependent protein kinase (PKA) activity in T cells after stimulation of the prostaglandin E2 or the β-adrenergic receptors: relationship between PKA activity and inhibition of anti-CD3 monoclonal antibody-induced T cell proliferation. Cell Immunol 1994; 158:18294.
  • 35
    Minakuchi R, Wacholtz MC, Davis LS, Lipsky PE. Delineation of the mechanism of inhibition of human T cell activation by PGE2. J Immunol 1990; 145:261625.
  • 36
    Roper RL, Brown DM, Phipps RP. Prostaglandin E2 promotes B lymphocyte Ig isotype switching to IgE. J Immunol 1995; 154:162 70.
  • 37
    Albert DA. The effect of cyclic-AMP on the regulation of c-myc expression in T lymphoma cells. J Clin Invest 1995; 95:14906.
  • 38
    Kolenko V, Rayman P, Roy B et al. Downregulation of JAK3 protein levels in T lymphocytes by prostaglandin E2 and other cyclic adenosine monophosphate-elevating agents: impact on interleukin-2 receptor signaling pathway. Blood 1999; 93:230818.
  • 39
    Gurlo T, Huang WW, Von Grafenstein H. PGE2 inhibits IL-2 and IL-4-dependent proliferation of CTLL-2 and HT2 cells. Cytokine 1998; 10:26574.
  • 40
    Thellin O, Coumans B, Zorzi W, Igout A, Heinen E. Tolerance to the feto-placental ‘graft’: ten ways to support a child for nine months. Curr Opin Immunol 2000; 12:7317.
  • 41
    Joshi PC, Zhou X, Cuchens M, Jones Q. Prostaglandin E2 suppressed IL-15-mediated human NK cell function through down-regulation of common γ-chain. J Immunol 2001; 166:88591.
  • 42
    Bloom D, Jabrane-Ferrat N, Zeng L et al. Prostaglandin E2 enhancement of interferon-gamma production by antigen-stimulated type 1 helper T cells. Cell Immunol 1999; 194:217.
  • 43
    Zeng L, An S, Goetzl EJ. Selective regulation of RNK-16 cell matrix metalloproteinases by the EP4 subtype of prostaglandin E2 receptor. Biochemistry 1996; 35:715964.