• 1
    Kincade PW, Medina KL, Smithson G. Sex hormones as negative regulators of lymphopoiesis. Immunol Rev 1994; 137:11934.
  • 2
    Grossman CJ. Regulation of the immune system by sex steroids. Endocrine Rev 1984; 5:43555.
  • 3
    Whitacre CC, Reingold SC, O’Looney PA. A gender gap in autoimmunity. Science 1999; 283:12778.DOI: 10.1126/science.283.5406.1277
  • 4
    Loven MA, Wood JR, Nardulli AM. Interaction of estrogen receptors alpha and beta with estrogen response elements. Mol Cell Endocrinol 2001; 181:15163.
  • 5
    Eidinger D, Garrett TJ. Studies of the regulatory effects of the sex hormones on antibody formation and stem cell differentiation. J Exp Med 1972; 136:1098116.
  • 6
    Butterworth M, McClellan B, Allansmith M. Influence of sex hormones on immunoglobulin levels. Nature (Lond) 1967; 214:12245.
  • 7
    Terres G, Morrison SL, Habicht GS. A quantitative difference in the immune response between male and female mice. Proc Soc Exp Biol Medical 1968; 127:6647.
  • 8
    Lichtman MA, Vaughan JH, Hames CG. The distribution of serum immunoglobulins, anti-gamma-G globulins (‘rheumatoid factors’) and antinuclear antibodies in White and Negro subjects in Evans County, Georgia. Arthritis Rheum 1967; 10:20415.
  • 9
    Amadori A, Zamarchi R, De Silvestro G et al. Genetic control of the CD4/CD8 T-cell ratio in humans. Nat Med 1995; 1:127983.
  • 10
    Medina KL, Smithson G, Kincade PW. Supression of B lymphopoeisis during normal pregnancy. J Exp Med 1993; 178:150715.
  • 11
    Medina KL, Kincade PW. Pregnancy-related steroids are potential negative regulators of B lymphopoiesis. Proc Natl Acad Sci USA 1994; 91:53826.
  • 12
    Nilsson N, Carlsten H. Estrogen induces suppression of natural killer cell cytotoxicity and augmentation of polyclonal B cell activation. Cell Immunol 1994; 158:1319.DOI: 10.1006/cimm.1994.1262
  • 13
    Kanda N, Tamaki K. Estrogen enhances immunoglobulin production by human PBMCs. J Allergy Clin Immunol 1999; 103:2828.
  • 14
    Paavonen T, Andersson LC, Adlercreutz H. Sex hormone regulation of in vitro immune response. Estradiol enhances human B cell maturation via inhibition of suppressor T cells in pokeweed mitogen- stimulated cultures. J Exp Med 1981; 154:193545.
  • 15
    Sthoeger ZM, Chiorazzi N, Lahita RG. Regulation of the immune response by sex hormones. I. In vitro effects of estradiol and testosterone on pokeweed mitogen-induced human B cell differentiation. J Immunol 1988; 141:918.
  • 16
    Wira CR, Sandoe CP. Sex steroid hormone regulation of IgA and IgG in rat uterine secretions. Nature 1977; 268:5346.
  • 17
    Schumacher GF, Kim MH, Hosseinian AH, Dupon C. Immunoglobulins, proteinase inhibitors, albumin, and lysozyme in human cervical mucus. I. Communication: hormonal profiles and cervical mucus changes – methods and results. Am J Obstet Gynecol 1977; 129:62936.
  • 18
    Kutteh WH, Prince SJ, Hammond KR, Kutteh CC, Mestecky J. Variations in immunoglobulins and IgA subclasses of human uterine cervical secretions around the time of ovulation. Clin Exp Immunol 1996; 104:53842.
  • 19
    Lü FX, Ma Z, Rourke T, Srinivasan S, McChesney M, Miller CJ. Immunoglobulin concentrations and antigen-specific antibody levels in cervico-vaginal lavages of rhesus macaques are influenced by the stage of the menstrual cycle. Infect Immun 1999; 67:63218.
  • 20
    Ma Z, Lu FX, Torten M, Miller CJ. The number and distribution of immune cells in the cervico-vaginal mucosa remain constant throughout the menstrual cycle of rhesus macaques. Clin Immunol 2001; 100:2409.
  • 21
    Taussky HH. A microcolorimetric determination of creatine in urine by the Jaffe reaction. J Biol Chem 1954; 208:85361.
  • 22
    Abel K, Alegria-Hartman MJ, Zanotto K, McChesney MB, Marthas ML, Miller CJ. Anatomic site and immune function correlate with relative cytokine mRNA expression levels in lymphoid tissues of normal rhesus macaques. Cytokine 2001; 16:1438.
  • 23
    Franklin RD, Kutteh WH. Characterization of immunoglobulins and cytokines in human cervical mucus: influence of exogenous and endogenous hormones. J Reprod Immunol 1999; 42:93106.
  • 24
    Kutteh WH, Moldoveanu Z, Mestecky J. Mucosal immunity in the female reproductive tract. correlation of immunoglobulins, cytokines, and reproductive hormones in human cervical mucus around the time of ovulation. AIDS Res Hum Retroviruses 1998; 14 (Suppl. 1):S515.
  • 25
    Hildesheim A, McShane LM, Schiffman M et al. Cytokine and immunoglobulin concentrations in cervical secretions: reproducibility of the Weck-cel collection instrument and correlates of immune measures. J Immunol Meth 1999; 225:13143.
  • 26
    Fu YS, Reagan JW. Pathology of the uterine cervix, vagina and vulva. Philadelphia: WB Saunders, 1989.
  • 27
    Turner M. Antibodies and their receptors. In: Roitt I, Brostoff J, Male D, eds. Immunology. London: Mosby, 1996:4.3.
  • 28
    McKenzie CE, Berczi I. Oestrogen dependent suppression of mitogen response in rat lymphocytes. Acta Endocrinol (Copenh) 1987; 116: 2004.
  • 29
    Holdstock G, Chastenay BF, Krawitt EL. Effects of testosterone, oestradiol and progesterone on immune regulation. Clin Exp Immunol 1982; 47:44956.
  • 30
    Stimson WH. Oestrogen and human T lymphocytes: presence of specific receptors in the T-suppressor/cytotoxic subset. Scand J Immunol 1988; 28:34550.
  • 31
    Fox HS, Bond BL, Parslow TG. Estrogen regulates the IFN-gamma promoter. J Immunol 1991; 146:43627.
  • 32
    Grasso G, Muscettola M. The influence of beta-estradiol and progesterone on interferon gamma production in vitro. Int J Neurosci 1990; 51:3157.
  • 33
    Koch F, Stanzl U, Jennewein P et al. High level IL-12 production by murine dendritic cells. Upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10. J Exp Med 1996; 184:7416.
  • 34
    Kang K, Kubin M, Cooper KD, Lessin SR, Trinchieri G, Rook AH. IL-12 synthesis by human Langerhans cells. J Immunol 1996; 156: 14027.
  • 35
    D’Andrea A, Rengaraju M, Valiante NM et al. Production of natural killer cell stimulatory factor (NKSF/IL 12) by peripheral blood mononuclear cells. J Exp Med 1992; 176:138798.
  • 36
    Banchereau J, Briere F, Caux C et al. Immunobiology of dendritic cells. Annu Rev Immunol 2000; 18:767811.
  • 37
    Gulshan S, McCruden AB, Stimson WH. Oestrogen receptors in macrophages. Scand J Immunol 1990; 31:6917.
  • 38
    Majlessi L, Bordenave G. The T/B cell interaction involved in induction of the mouse IgG2ab suppression is restricted by major histocompatibility complex class I, but not class II molecules. Eur J Immunol 1997; 27:134652.
  • 39
    Majlessi L, Benaroch P, Bordenave G. T cell-induced allotypic suppression. Origin of the CD8+ T cells maintaining IgG2ab suppression. J Immunol 1992; 149:18818.
  • 40
    Shustov A, Luzina I, Nguyen P et al. Role of perforin in controlling B-cell hyperactivity and humoral autoimmunity. J Clin Invest 2000; 106:3947.
  • 41
    Specht C, Junker R, Kruger A, Rademaekers A, Redlich H, Kolsch E. Involvement of CD28 cosignalling in the T cell-mediated suppression of the IgG antibody response against the TI-2 antigen alpha (1[RIGHTWARDS ARROW]3) dextran. Immunobiology 1999; 201:4963.
  • 42
    Via CS, Nguyen P, Shustov A, Drappa J, Elkon KB. A major role for the Fas pathway in acute graft-versus-host disease. J Immunol 1996; 157:538793.
  • 43
    Eriksson K, Nordstrom I, Horal P et al. Amplified ELISPOT assay for the detection of HIV-specific antibody-secreting cells in subhuman primates. J Immunol Meth 1992; 153:10713.
  • 44
    Dresser DW, Taub RN, Krantz AR. The effect of localized injection of adjuvant material on the draining lymph node. II. Circulating lymphocytes. Immunology 1970; 18:66370.
  • 45
    Kubota M, Miller CJ, Imaoka K et al. Oral immunization with simian immunodeficiency virus (SIV) p55 gag and cholera toxin elicits both mucosal IgA and systemic immune responses in non-human primates. J Immunol 1997; 158:53219.
  • 46
    Imaoka K, Miller CJ, Kubota M et al. Nasal immunization of nonhuman primates with simian immunodeficiency virus p55gag and cholera toxin adjuvant induces Th1/Th2 help for virus-specific immune responses in reproductive tissues. J Immunol 1998; 161:59528.
  • 47
    Morris L, Binley JM, Clas BA et al. HIV-1 antigen-specific and -nonspecific B cell responses are sensitive to combination antiretroviral therapy. J Exp Med 1998; 188:23345.
  • 48
    Crowley-Nowick PA, Bell M, Edwards RP et al. Normal uterine cervix: characterization of isolated lymphocyte phenotypes and immunoglobulin secretion. Am J Reprod Immunol 1995; 34:2417.
  • 49
    Czerkinsky C, Prince SJ, Michalek SM et al. IgA antibody-producing cells in peripheral blood after antigen ingestion: evidence for a common mucosal immune system in humans. Proc Natl Acad Sci USA 1987; 84:244953.