• 1
    Boitard C, Yasunami R, Dardenne M, Bach JF. T cell-mediated inhibition of the transfer of autoimmune diabetes in NOD mice. J Exp Med 1989; 169: 166980.
  • 2
    Olivares-Villagomez D, Wang Y, Lafaille JJ. Regulatory CD4 (+) T cells expressing endogenous T cell receptor chains protect myelin basic protein-specific transgenic mice from spontaneous autoimmune encephalomyelitis. J Exp Med 1998; 188: 188394.
  • 3
    Olivares-Villagomez D, Wensky AK, Wang Y, Lafaille JJ. Repertoire requirements of CD4+ T cells that prevent spontaneous autoimmune encephalomyelitis. J Immunol 2000; 164: 5499507.
  • 4
    Van de Keere F, Tonegawa S. CD4 (+) T cells prevent spontaneous experimental autoimmune encephalomyelitis in anti-myelin basic protein T cell receptor transgenic mice. J Exp Med 1998; 188: 187582.
  • 5
    Hodes RJ. Cloned Lyt-1+, 2- T suppressor cells – a commentary. J Mol Cell Immunol 1985; 2: 146.
  • 6
    Hertel-Wulff B, Lindsten T, Schwadron R, Gilbert DM, Davis MM, Strober S. Rearrangement and expression of T cell receptor genes in cloned murine natural suppressor cell lines. J Exp Med 1987; 166: 116873.
  • 7
    Davis MM, Cohen DI, Nielsen EA, Steinmetz M, Paul WE, Hood L. Cell-type-specific cDNA probes and the murine I region: the localization and orientation of Ad alpha. Proc Natl Acad Sci USA 1984; 81: 21948.
  • 8
    Murphy DB. The I-J puzzle. Annu Rev Immunol 1987; 5: 40527.
  • 9
    Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986; 136: 234857.
  • 10
    Rizzo LV, DeKruyff RH, Umetsu DT, Caspi RR. Regulation of the interaction between Th1 and Th2 T cell clones to provide help for antibody production in vivo. Eur J Immunol 1995; 25: 70816.
  • 11
    Fishman MA, Perelson AS. Th1/Th2 cross regulation. J Theor Biol 1994; 170: 2556.
  • 12
    Powrie F, Correa-Oliveira R, Mauze S, Coffman RL. Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity. J Exp Med 1994; 179: 589600.
  • 13
    Quinn A, McInerney B, Reich EP, Kim O, Jensen KP, Sercarz EE. Regulatory and effector CD4 T cells in nonobese diabetic mice recognize overlapping determinants on glutamic acid decarboxylase and use distinct V beta genes. J Immunol 2001; 166: 298291.
  • 14
    Sakaguchi S, Sakaguchi N, Shimizu J et al. Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells. their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol Rev 2001; 182: 1832.
  • 15
    Roncarolo MG, Bacchetta R, Bordignon C, Narula S, Levings MK. Type 1 T regulatory cells. Immunol Rev 2001; 182: 6879.
  • 16
    Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995; 155: 115164.
  • 17
    Sakaguchi S, Toda M, Asano M, Itoh M, Morse SS, Sakaguchi N. T cell-mediated maintenance of natural self-tolerance: its breakdown as a possible cause of various autoimmune diseases. J Autoimmun 1996; 9: 21120.
  • 18
    Asano M, Toda M, Sakaguchi N, Sakaguchi S. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J Exp Med 1996; 184: 38796.
  • 19
    Itoh M, Takahashi T, Sakaguchi N, Kuniyasu Y, Shimizu J, Otsuka F, Sakaguchi S. Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J Immunol 1999; 162: 531726.
  • 20
    Takahashi T, Kuniyasu Y, Toda M, Sakaguchi N, Itoh M, Iwata M, Shimizu J, Sakaguchi S. Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int Immunol 1998; 10: 196980.
  • 21
    Zhang ZX, Yang L, Young KJ, DuTemple B, Zhang L. Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression. Nat Med 2000; 6: 7829.
  • 22
    Gregori S, Casorati M, Amuchastegui S, Smiroldo S, Davalli AM, Adorini L. Regulatory T cells induced by 1 alpha,25-dihydroxyvitamin D3 and mycophenolate mofetif treatment mediate transplantation tolerance. J Immunol 2001; 167: 194553.
  • 23
    Groux H, O'Garra A, Bigler M, Rouleau M, Antonenko S, De Vries JE, Roncarolo MG. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 1997; 389: 73742.
  • 24
    Yamagiwa S, Gray JD, Hashimoto S, Horwitz OA. A role for TGF-beta in the generation and expansion of CD4+CD25+ regulatory T cells from human peripheral blood. J Immunol 2001; 166: 72827289.
  • 25
    Rizzo LV, DeKruyff RH, Umetsu DT. Generation of B cell memory and affinity maturation. Induction with Th1 and Th2 T cell clones. J Immunol 1992; 148: 37339.
  • 26
    Cunha-Neto E, Rizzo LV. Prostaglandin E2 inhibits proliferation but not interleukin-2 production by phorbol ester plus calcium ionophore-activated murine T cell clones. Braz J Med Biol Res 1989; 22: 36577.
  • 27
    Rizzo LV, Umetsu DT, DeKruyff RH. Differential regulation of antigen presentation in high- and low-IgE responder mice. Eur J Immunol 1991; 21: 176770.
  • 28
    DeKruyff RH, Rizzo LV, Umetsu DT. Induction of immunoglobulin synthesis by CD4+ T cell clones. Semin Immunol 1993; 5: 42130.
  • 29
    Wahl SM, Dougherty SF. Measurement of Transforming Growth Factor β in Current Protocols in Immunology, Vol. 1 (eds. Coligan JE, Kruisbeek AM, Margulies OH, Shevach EM, Strober WJ). New York: Green Publishing Associates and Wiley–Interscience, 1991;
  • 30
    Ramshaw HS, Woodcock JM, Bagley CJ, McClure BJ, Hercus TR, Lopez AF. New approaches in the treatment of asthma. Immunol Cell Biol 2001; 79: 1549.
    Direct Link:
  • 31
    Sun B, Rizzo LV, Sun SH, Chan CC, Wiggert B, Wilder RL, Caspi RR. Genetic susceptibility to experimental autoimmune uveitis involves more than a predisposition to generate a T helper-1-like or a T helper-2-like response. J Immunol 1997; 159: 100411.
  • 32
    Racke MK, Bonomo A, Scott DE, Cannella B, Levine A, Raine CS, Shevach EM, Rocken M. Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease. J Exp Med 1994; 180: 19616.
  • 33
    Bach JF. Non-Th2 regulatory T-cell control of Th1autoimmunity. Scand J Immunol 2001; 54: 219.
  • 34
    Tsokos GC. Lymphocytes, cytokines, inflammation, and immune trafficking. Curr Opin Rheumatol 1996; 8: 395402.
  • 35
    Van der Meide PH, Schellekens H. Cytokines and the immune response. Biotherapy 1996; 8: 2439.
  • 36
    Annacker O, Burlen-Defranoux O, Pimenta-Araujo R, Cumano A, Bandeira A. Regulatory CD4 T cells control the size of the peripheral activated/memory CD4 T cell compartment. J Immunol 2000; 164: 357380.
  • 37
    Chen Y, Kuchroo VK, Inobe J, Hafler DA, Weiner HL. Regulatory T cell clones induced by oral tolerance. suppression of autoimmune encephalomyelitis. Science 1994; 265: 123740.
  • 38
    Furtado CG, Olivares-Villagomez D, Curotto De Lafaille MA, Wensky AK, Latkowski JÁ, Lafaille JJ. Regulatory T cells in spontaneous autoimmune encephalomyelitis. Immunol Rev 2001; 182: 12234.
  • 39
    Rizzo LV, Morawetz RA, Miller-Rivero NE, Choi R, Wiggert B, Chan CC, Morse HC 3rd, Nussenblatt RB, Caspi RR. IL-4 and IL-10 are both required for the induction of oral tolerance. J Immunol 1999; 162: 261322.
  • 40
    Gonnella PA, Chen Y, Inobe J, Komagata Y, Quartulli M, Weiner HL. In situ immune response in gut-associated lymphoid tissue (GALT) following oral antigen in TCR-transgenic mice. J Immunol 1998; 160: 470818.
  • 41
    De Waal Malefyt R, Haanen J, Spits H et al. Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression. J Exp Med 1991; 174: 91524.
  • 42
    Kuhn R, Lohler J, Rennick D, Rajewsky K, Muller W. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 1993; 75: 26374.
  • 43
    Fiorentino DF, Zlotnik A, Vieira P, Mosmann TR, Howard M, Moore KW, O'Garra A. IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells. J Immunol 1991; 146: 344451.
  • 44
    Koppelman B, Neefjes JJ, De Vries JE, De Waal Malefyt R. Interleukin-10 down-regulates MHC class II alphabeta peptide complexes at the plasma membrane of monocytes by affecting arrival and recycling. Immunity 1997; 7: 86171.
  • 45
    Bridoux F, Badou A, Saoudi A, Bernard I, Druet E, Pasquier R, Druet P, Pelletier L. Transforming growth factor beta (TGF-beta)-dependent inhibition of T helper cell 2 (Th2)-induced autoimmunity by self-major histocompatibility complex (MHC) class II-specific regulatory CD4 (+) T cell lines. J Exp Med 1997; 185: 176975.
  • 46
    Chang CH, Furue M, Tamaki K. B7–1 expression of Langerhans cells is up-regulated by proinflammatory cytokines, and is down-regulated by interferon-gamma or by interleukin-10. Eur J Immunol 1995; 25: 3948.
  • 47
    Willems F, Marchant A, Delville JP, Gerard C, Delvaux A, Velu T, De Boer M, Goldman M. Interleukin-10 inhibits B7 and intercellular adhesion molecule-1 expression on human monocytes. Eur J Immunol 1994; 24: 10079.
  • 48
    Fiorentino DF, Zlotnik A, Mosmann TR, Howard M, O'Garra A. IL-10 inhibits cytokine production by activated macrophages. J Immunol 1991; 147: 381522.
  • 49
    Sutmuller RP, Van Duivenvoorde LM, Van Elsas A et al. Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25 (+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses. J Exp Med 2001; 194: 82332.
  • 50
    Jonuleit H, Schmitt E, Stassen M, Tuettenberg A, Knop J, Enk AH. Identification and functional characterization of human CD4 (+) CD25 (+) T cells with regulatory properties isolated from peripheral blood. J Exp Med 2001; 193: 128594.
  • 51
    Takahashi T, Tagami T, Yamazaki S, Uede T, Shimizu J, Sakaguchi N, Mak TW, Sakaguchi S. Immunologic self-tolerance maintained by CD25 (+) CD4 (+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med 2000; 192: 30310.
  • 52
    Salomon B, Lenschow DJ, Rhee L, Ashourian N, Singh B, Sharpe A, Bluestone JAB, 7/, CD. 28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity 2000; 12: 43140,.
  • 53
    Seder RA, Marth T, Sieve MC, Strober W, Letterio JJ, Roberts AB, Kelsall B. Factors involved in the differentiation of TGF-beta-producing cells from naive CD4+ T cells: IL-4 and IFN-gamma have opposing effects, while TGF-beta positively regulates its own production. J Immunol 1998; 160: 571928.
  • 54
    Frauwirth KA, Alegre ML, Thompson CB. CTLA-4 is not required for induction of CD8 (+) T cell anergy in vivo. J Immunol 2001; 167: 493641.
  • 55
    Cohen IR. T-cell vaccination for autoimmune disease: a panorama. Vaccine 2001; 20: 70610.
  • 56
    Ben-Yehuda A, Bar-Tana R, Livoff A, Ron N, Cohen IR, Naparstek Y. Lymph node cell vaccination against the lupus syndrome of MRL/lpr/lpr mice. Lupus 1996; 5: 2326.
  • 57
    Ben-Nun A, Cohen IR. Vaccination against autoimmune encephalomyelitis (EAE). attenuated autoimmune T lymphocytes confer resistance to induction of active EAE but not to EAE mediated by the intact T lymphocyte line. Eur J Immunol 1981; 11: 94952.
  • 58
    Lohse AW, Dienes HP, Meyer zum Buschenfelde KH. Suppression of murine experimental autoimmune hepatitis by T-cell vaccination or immunosuppression. Hepatology 1998; 27: 153643.
  • 59
    Van Laar JM, Miltenburg AM, Verdonk MJ et al. Effects of inoculation with attenuated autologous T cells in patients with rheumatoid arthritis. J Autoimmun 1993; 6: 15967.
  • 60
    Stinissen P, Zhang J, Medaer R, Vandevyver C, Raus J. Vaccination with autoreactive T cell clones in multiple sclerosis. overview of immunological and clinical data. J Neurosci Res 1996; 45: 50011.
  • 61
    Kumar V, Sercarz E. T cell regulatory circuitry: antigen-specific and TCR-idiopeptide-specific T cell interactions in EAE. Int Rev Immunol 1993; 9: 28797.
  • 62
    Shevac EM. Regulatory T cells in autoimmmunity. Annu Rev Immunol 2000; 18: 42349.
  • 63
    Thornton AM, Shevach EM. CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med 1998; 188: 28796.
  • 64
    Itoh M, Mukasa A, Tokunaga Y, Hiramine C, Hojo K. Suppression of efferent limb of testicular autoimmune response by a regulatory CD4+ T cell line in mice. Clin Exp Immunol 1992; 87: 45560.
  • 65
    Seddon B, Mason D. The third function of the thymus. Immunol Today 2000; 21: 959.
  • 66
    Groux H. An overview of regulatory T cells. Microbes Infect 2001; 3: 8839.
  • 67
    Lohse AW, Spahn TW, Wolfel T, Herkel J, Cohen IR, Meyer zum Buschenfelde KH. Induction of the anti-ergotypic response. Int Immunol 1993; 5: 5339.