• 1
    Medawar PB. Some immunological and endocrinological problems raised by the evolution of viviparity in vertebrates. Symp Soc Exp Biol 1953; 7: 32038.
  • 2
    Sargent IL. Maternal and fetal immune responses during pregnancy. Exp Clin Immunogenet 1993; 10: 85102.
  • 3
    Wegmann TG, Lin H, Guilbert L, Mosmann TR. Bidirectional cytokine interactions in the maternal–fetal relationship: is successful pregnancy a TH2 phenomenon? Immunol Today 1993; 14: 3536.
  • 4
    Raghupathy R. Pregnancy: success and failure within the Th1/Th2/Th3 paradigm. Semin Immunol 2001; 13: 21927.
  • 5
    Marzi M, Vigano A, Trabattoni D et al. Characterization of type 1 and type 2 cytokine production profile in physiologic and pathologic human pregnancy. Clin Exp Immunol 1996; 106: 12733.
  • 6
    Saito S, Sakai M, Sasaki Y, Tanebe K, Tsuda H, Michimata T. Quantitative analysis of peripheral blood Th0, Th1, Th2 and the Th1 : Th2 cell ratio during normal human pregnancy and preeclampsia. Clin Exp Immunol 1999; 117: 5505.
  • 7
    Sacks GP, Studena K, Sargent IL, Redman CWG. Normal pregnancy and pre-eclampsia both produce inflammatory changes in peripheral blood leucocytes akin to sepsis. Am J Obstet Gynecol 1998; 179: 806.
  • 8
    Smarason AK, Gunnarsson A, Alfredsson JH, Valdimarsson H. Monocytosis and monocytic infiltration of decidua in early pregnancy. J Clin Laboratoryimmunol 1986; 21: 15.
  • 9
    Shibuya T, Izuchi K, Kuroiwa A, Okabe N, Shirakawa K. Study on nonspecific immunity in pregnant women: increased chemiluminescence response of peripheral blood phagocytes. Am J Reprod Immunol Microbiol 1987; 15: 1923.
  • 10
    Hanlon AM, Jang S, Salgame P. Signaling from cytokine receptors that affect Th1 responses. Front Biosci 2002; 7: 124754.
  • 11
    Trinchieri G. Cytokines acting on or secreted by macrophages during intracellular infection (IL-10, IL-12, IFN-gamma). Curr Opin Immunol 1997; 9: 1723.
  • 12
    Dudley DJ, Hunter C, Mitchell MD, Varner MW, Gately M. Elevations of serum interleukin-12 concentrations in women with severe pre-eclampsia and HELLP syndrome. J Reprod Immunol 1996; 31: 97107.
  • 13
    Kupferminc MJ, Peaceman AM, Wigton TR, Tamura RK, Rehnberg KA, Socol ML. Immunoreactive tumor necrosis factor-alpha is elevated in maternal plasma but undetected in amniotic fluid in the second trimester. Am J Obstet Gynecol 1994; 171: 9769.
  • 14
    Prussin C, Metcalfe DD. Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies. J Immunol Meth 1995; 188: 11728.
  • 15
    Elson LH, Nutman TB, Metcalfe DD, Prussin C. Flow cytometric analysis for cytokine production identifies T helper 1, T helper 2, and T helper 0 cells within the human CD4+CD27- lymphocyte subpopulation. J Immunol 1995; 154: 4294301.
  • 16
    Openshaw P, Murphy EE, Hosken NA et al. Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations. J Exp Med 1995; 182: 135767.
  • 17
    De Caestecker MP, Telfer BA, Hutchinson IV, Ballardie FW. The detection of intracytoplasmic interleukin-1 alpha, interleukin-1 beta and tumour necrosis factor alpha expression in human monocytes using two colour immunofluorescence flow cytometry. J Immunol Meth 1992; 154: 1120.
  • 18
    Fujishima S, Nakamura H, Waki Y et al. Cell-associated IL-8 in human blood monocytes: analysis by flow cytometry. Cytometry 1996; 24: 3829.
  • 19
    Sacks GP, Clover LM, Bainbridge DR, Redman CW, Sargent IL. Flow cytometric measurement of intracellular Th1 and Th2 cytokine production by human villous and extravillous cytotrophoblast. Placenta 2001; 22: 5509.
  • 20
    North ME, Ivory K, Funauchi M, Webster AD, Lane AC, Farrant J. Intracellular cytokine production by human CD4+ and CD8+ T cells from normal and immunodeficient donors using directly conjugated anti-cytokine antibodies and three-colour flow cytometry. Clin Exp Immunol 1996; 105: 51722.
  • 21
    Nakazawa M, Sugi N, Kawaguchi H, Ishii N, Nakajima H, Minami M. Predominance of type 2 cytokine-producing CD4+ and CD8+ cells in patients with atopic dermatitis. J Allergy Clin Immunol 1997; 99: 67382.
  • 22
    Cambronero R, Sewell WA, North ME, Webster AD, Farrant J. Up-regulation of IL-12 in monocytes: a fundamental defect in common variable immunodeficiency. J Immunol 2000; 164: 48894.
  • 23
    Wittmann M, Larsson VA, Schmidt P, Begemann G, Kapp A, Werfel T. Suppression of interleukin-12 production by human monocytes after preincubation with lipopolysaccharide. Blood 1999; 94: 171726.
  • 24
    Chen GR, Wilson Wang SH, Zheng HZ, Walker JJ, McKillop JH. Tumour necrosis factor-alpha (TNF-alpha) gene polymorphism and expression in pre-eclampsia. Clin Exp Immunol 1996; 104: 1549.
  • 25
    Sakai M, Tsuda H, Tanebe K, Sasaki Y, Saito S. Interleukin-12 secretion by peripheral blood mononuclear cells is decreased in normal pregnant subjects and increased in preeclamptic patients. Am J Reprod Immunol 2002; 47: 917.
  • 26
    Matthiesen L, Berg G, Ernerudh J, Hakansson L. Lymphocyte subsets and mitogen stimulation of blood lymphocytes in normal pregnancy. Am J Reprod Immunol 1996; 35: 709.
  • 27
    Lee H, Gregory CD, Rees GB, Scott IV, Golding PR. Cytotoxic activity and phenotypic analysis of natural killer cells in early normal human pregnancy. J Reprod Immunol 1987; 12: 3547.
  • 28
    Sacks GP, Sargent IL, Redman CWG. An innate view of human pregnancy. Immunol Today 1999; 20: 1148.
  • 29
    D’Andrea A, Ma X, Aste Amezaga M, Paganin C, Trinchieri G. Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production. J Exp Med 1995; 181: 53746.
  • 30
    Knight M, Redman CWG, Linton EA, Sargent IL. Syncytiotrophoblast microvilli are shed into the maternal circulation in increased amounts in pre-eclamptic pregnancy. Br J Obstet Gynaecol 1998; 105: 63240.
  • 31
    Redman CWG, Sargent IL. Placental debris, oxidative stress and pre-eclampsia. Placenta 2000; 21: 597602.
  • 32
    Plevyak M, Hanna N, Mayer S et al. Deficiency of decidual IL-10 in first trimester missed abortion: a lack of correlation with the decidual immune cell profile. Am J Reprod Immunol 2002; 47: 24250.
  • 33
    Michimata T, Ogasawara MS, Tsuda H et al. Distributions of endometrial NK cells, B cells, T cells an Th1/Th2 cells fail to predict pregnancy outcome following recurrent abortion. Am J Reprod Immunol 2002; 47: 196202.
  • 34
    Brabin BJ. Epidemiology of infection in pregnancy. Rev Infect Dis 1985; 7: 579603.
  • 35
    Mori W. The Shwartzman reaction: a review including clinical manifestations and proposal for a univisceral or single organ third type. Histopathology 1981; 5: 11326.
  • 36
    Ozmen L, Pericin M, Hakimi J et al. Interleukin 12, interferon gamma, and tumor necrosis factor alpha are the key cytokines of the generalized Shwartzman reaction. J Exp Med 1994; 180: 90715.
  • 37
    Redman CWG, Sacks GP, Sargent IL. Pre-eclampsia: an excessive maternal inflammatory response to pregnancy. Am J Obstet Gynecol 1999; 180: 499506.
  • 38
    Shiraishi H, Hayakawa S, Satoh K. Murine experimental abortion by IL-12 administration is caused by activation of cytotoxic T lymphocytes and placental apoptosis. Clin Laboratory Immunol 1996; 48: 93108.
  • 39
    Lemancewicz A, Urban R, Skotnicki M, Kretowska M, Sierakowski S. Evaluation of interleukin concentrations in amniotic fluid in preterm and term parturution and in oligohydramnios. Med Sci Monit 1997; 7: 9247.
  • 40
    Wong CK, Ho CY, Ko FW et al. Proinflammatory cytokines (IL-17, IL-6, IL-18 and IL-12) and Th cytokines (IFN-gamma, IL-4, IL-10 and IL-13) in patients with allergic asthma. Clin Exp Immunol 2001; 125: 17783.