The following were collaborators in the study:
Prospective audit of adverse reactions occurring in 459 primary antibody-deficient patients receiving intravenous immunoglobulin
Version of Record online: 17 JUL 2003
Clinical & Experimental Immunology
Volume 133, Issue 2, pages 247–251, August 2003
How to Cite
BRENNAN, V. M., SALOMÉ-BENTLEY, N. J., CHAPEL, H. M. and Immunology Nurses Study (2003), Prospective audit of adverse reactions occurring in 459 primary antibody-deficient patients receiving intravenous immunoglobulin. Clinical & Experimental Immunology, 133: 247–251. doi: 10.1046/j.1365-2249.2003.02199.x
Jane Abbey Great Ormond Street Hospital, Tracey Askew, Teresa Green Newcastle General Hospital, Sheila Cochrane Hope Hospital, Salford, Claire Fletcher, Claire Bennett Birmingham Heartlands Hospital, Cilla Freud, Annie Ryan Royal Free Hospital, London, Mary Haines Royal Brompton, London, Pauline Powell Queens Medical Centre, Nottingham, Delene Saunderson Royal Victoria Hospital, Belfast, Jan Short St. Helier Hospital, Carshalton, John Toolan St. James's Hospital, Leeds, Doreen Hendry, Oxford and Ann Wilkes, Southmead BTS, Bristol.
- Issue online: 17 JUL 2003
- Version of Record online: 17 JUL 2003
- (Accepted for publication 12 Mat 2003)
- adverse reactions;
- intravenous immunoglobulin;
- primary antibody deficiency
Intravenous immunoglobulin (IVIG) is used as the standard replacement therapy for patients with primary antibody deficiencies. A previous study of adverse reactions in patients self-infusing at home over 1 year showed an overall reaction rate of 0·7%. A larger prospective study is reported here, involving a greater number of immunology centres and including children and adults who received infusions from medical or nursing staff as well as those self-infusing. Four hundred and fifty-nine patients were entered into this study and 13 508 infusions were given. The study showed that no severe reactions occurred and the reaction rate was low at 0·8%. This figure could have been lower, 0·5%, if predisposing factors responsible for some reactions had been considered before infusion. In conclusion, the study shows the importance of ongoing training for patients and staff to recognize the predisposing factors to prevent avoidable reactions. Because none of these reactions were graded as severe, the present guidance to prescribe self-injectable adrenaline for patients infusing outside hospital should be reviewed.