• 1
    Hart PD, Sutherland I. BCG and vole bacillus vaccines in the prevention of tuberculosis in adolescence and early adult life. Br Med J 1977; 22: 2935.
  • 2
    Sutherland I, Springett VH. Effectiveness of BCG vaccination in England and Wales in 1983. Tubercle 1987; 68: 8192.
  • 3
    Karonga Prevention Trial Group. Randomized controlled trial of single BCG, repeated BCG, or combined BCG and killed Mycobacterium leprae vaccine for prevention of leprosy and tuberculosis in Malawi. Lancet 1996; 348: 1724.
  • 4
    Colditz GA, Berkey CS, Mosteller F, Brewer TF, Wilson ME, Burdick E, Fineberg HV. The efficacy of Bacillus Calmétte–Guerin vaccination of newborns and infants in the prevention of tuberculosis: meta-analysis of the published literature. Pediatrics 1995; 96: 2935.
  • 5
    Rodrigues LC, Diwan VK, Wheeler JG. Protective effect of BCG against tuberculous meningitis and miliary tuberculosis: a meta-analysis. Int J Epidemiol 1993; 22: 11548.
  • 6
    Orme IM, Roberts AD, Griffin JP, Abrams JS. Cytokine secretion by CD4 T lymphocytes acquired in response to Mycobacterium tuberculosis infection. J Immunol 1993; 151: 51825.
  • 7
    Tascon RE, Stavropoulos E, Lukacs KV, Colston MJ. Protection against Mycobacterium tuberculosis infection by CD8+ T cells requires the production of gamma interferon. Infect Immun 1998; 66: 8304.
  • 8
    Lein D, Von Reyn F. In vitro cellular and cytokine responses to mycobacterial antigens: application to diagnosis of tuberculosis infection and assessment of response to mycobacterial vaccines. Am J Med Sci 1997; 313: 36471.
  • 9
    Van Pinxteren LAH, Ravn P, Agger EM, Pollock J, Andersen P. Diagnosis of tuberculosis based on the two specific antigens ESAT-6 and CFP10. Clin Diagn Lab Immunol 2000; 7: 15560.
  • 10
    Dockrell HM, Weir RE. Whole blood cytokine assays – a new generation of diagnostic tests for tuberculosis? Int J Tuberc Lung Dis 1998; 2: 4412.
  • 11
    Smith SM, Klein MR, Malin AS, Sillah J, McAdam KP, Dockrell HM. Decreased IFN-gamma and increased IL-4 production by human CD8(+) T cells in response to Mycobacterium tuberculosis in tuberculosis patients. Tuberculosis 2002; 82: 713.
  • 12
    Ewer K, Deeks J, Alvarez L, Bryant G, Waller S, Andersen P, Monk P, Lalvani A. Comparison of T-cell-based assay with tuberculin skin test for diagnosis of Mycobacterium tuberculosis infection in a school tuberculosis outbreak. Lancet 2003; 361: 116873.
  • 13
    Streeton JA, Desem N, Jones SL. Sensitivity and specificity of a gamma interferon blood test for tuberculosis infection. Int J Tuberc Lung Dis 1998; 2: 44350.
  • 14
    Black GF, Weir RE, Floyd S et al. BCG-induced increase in interferon-gamma response to mycobacterial antigens and efficacy of BCG vaccination in Malawi and the UK: two randomised controlled studies. Lancet 2002; 359: 1393401.
  • 15
    Black GF, Fine PEM, Warndorff DK et al. Relationship between IFN-γ and skin test responsiveness to Mycobacterium tuberculosis PPD in healthy, non-BCG-vaccinated young adults in Northern Malawi. Int J Tuberc Lung Dis 2001; 5: 66472.
  • 16
    Black GF, Dockrell HM, Crampin AC et al. Patterns and implications of naturally acquired immune responses to environmental and tuberculous mycobacterial antigens in Northern Malawi. J Infect Dis 2001; 184: 3229.
  • 17
    Department of Health. Tuberculosis: BCG immunisation. In: SalisburyDM, BeggNT, eds. Immunisation against infectious disease, 2nd edn. London: HMSO, 1996:231232.
  • 18
    Donoghue HD, Overend E, Stanford JL. A longitudinal study of environmental mycobacteria on a farm in south-west England. J Appl Microbiol 1997; 82: 5767.
  • 19
    Lamden K, Watson JM, Knerer G, Ryan MJ, Jenkins PA. Opportunist mycobacteria in England and Wales: 1982–94. CDR Rev 1996; 6: R147R151.
  • 20
    Fonteyne PA, Kunze ZM, De Beenhouwer H, Dumonceau JM, Dawson DJ, McFadden JJ, Portaels F. Characterization of Mycobacterium avium complex related mycobacteria isolated from an African environment and patients with AIDS. Trop Med Int Health 1997; 2: 2007.
  • 21
    Great Britain Medical Research Council. BCG and vole bacillus vaccines in the prevention of tuberculosis in adolescence and early adult life. Fourth report to the Medical Research Council by its Tuberculosis Vaccines Clinical Trials Committee. Bull WHO 1972; 46: 37185.
  • 22
    Fine PEM, Floyd S, Stanford JL et al. Environmental mycobacteria in northern Malawi: implications for the epidemiology of tuberculosis and leprosy. Epidemiol Infec 2001; 126: 37987.
  • 23
    Cobelens FGJ, Van Deutekom H, Draayer-Jansen IWE, Schepp-Beelen ACHM, Van Gerven PJHJ, Van Kessel RPM, Mensen MEA. Risk of infection with Mycobacterium tuberculosis in travellers to areas of high tuberculosis endemicity. Lancet 2000; 356: 4615.
  • 24
    Fine PEM. Variation in protection by BCG: implications of and for heterologous immunity. Lancet 1995; 346: 133945.
  • 25
    Orme IM, Collins FM. Adoptive protection of the Mycobacterium tuberculosis-infected lung. Dissociation between cells that passively transfer protective immunity and those that transfer delayed-type hypersensitivity to tuberculin. Cell Immunol 1984; 84: 11320.
  • 26
    Brandt L, Cunha JF, Olsen AW, Chilima B, Hirsch P, Appelberg R, Andersen P. Failure of the Mycobacterium bovis BCG vaccine: some species of environmental mycobacteria block multiplication of BCG and induction of protective immunity to tuberculosis. Infect Immun 2002; 70: 6728.
  • 27
    Palmer CE, Long MW. Effects of infection with atypical mycobacteria on BCG vaccination and tuberculosis. Am Rev Respir Dis 1966; 94: 55368.