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Keywords:

  • Azathioprine;
  • dermatomyositis;
  • monosomy 7;
  • secondary acute myeloid leukaemia

A 66-year-old female with dermatomyositis (DM) who had received immunosuppressive therapy with azathioprine developed acute myeloid leukaemia (AML). Cytogenetic analysis revealed a complex karyotype including monosomy 7, and trilineage dysplastic features strongly suggestive of a treatment-related aetiology. The literature on azathioprine-associated AML is reviewed.