Health-related quality of life, symptom distress and sense of coherence in adult survivors of allogeneic stem-cell transplantation

Authors

  • L. Edman,

    1. Centre for Allogeneic Stem Cell Transplantation, Huddinge University Hospital1Department of Nursing2Department of Haematology, Karolinsk a Institutet3Nursing Care Research and Development Unit, Huddinge University Hospital/Department of Nursing, Karolinska Institutet, Stockholm, Sweden
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  • J. Larsen RN, PHD, CANDIDATE,

    1. Centre for Allogeneic Stem Cell Transplantation, Huddinge University Hospital1Department of Nursing2Department of Haematology, Karolinsk a Institutet3Nursing Care Research and Development Unit, Huddinge University Hospital/Department of Nursing, Karolinska Institutet, Stockholm, Sweden
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  • 1 H. Hägglund MD, PHD,

    1. Centre for Allogeneic Stem Cell Transplantation, Huddinge University Hospital1Department of Nursing2Department of Haematology, Karolinsk a Institutet3Nursing Care Research and Development Unit, Huddinge University Hospital/Department of Nursing, Karolinska Institutet, Stockholm, Sweden
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  • 2 A. Gardulf RN, PHD,

    1. Centre for Allogeneic Stem Cell Transplantation, Huddinge University Hospital1Department of Nursing2Department of Haematology, Karolinsk a Institutet3Nursing Care Research and Development Unit, Huddinge University Hospital/Department of Nursing, Karolinska Institutet, Stockholm, Sweden
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  • and 3 Assistant Professor 3

    1. Centre for Allogeneic Stem Cell Transplantation, Huddinge University Hospital1Department of Nursing2Department of Haematology, Karolinsk a Institutet3Nursing Care Research and Development Unit, Huddinge University Hospital/Department of Nursing, Karolinska Institutet, Stockholm, Sweden
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Correspondence address: LEdman Nursing Care Research and Development Unit, M98, Huddinge University Hospital, SE-141 86 Stockholm, Sweden (e-mail: vardutvecklingsavdelningen@nursres.hs.sll.se)

Abstract

This is the first Swedish study to evaluate the health-related quality of life and sense of coherence in adult survivors of allogeneic, haematopoietic stem cell transplantation (HSCT). Twenty-five recipients completed three questionnaires 2–4 years after the transplantation. The questionnaires used were the Sickness Impact Profile (SIP), the Symptom Frequency Intensity and Distress (SFID-BMT) scale and the Sense of Coherence (SOC) scale measuring subjective functional status, symptom distress and coping ability. Impairments in functional status were found, as compared with a population norm. The most common impairments were found in the areas of social interaction and sleep and rest. Eye problems, dry mouth, cough, sexual problems, tiredness, anxiety and changes of taste were symptoms reported by more than half of the patients. Despite impaired functioning and a high incidence of symptoms, the general health was described as quite good or excellent by 80% (n = 20) of the patients. The majority (20/22) had also been able to return to work or to attend school. No difference in the sense of coherence was seen, as compared with the population norm. Functional impairments were significantly correlated to a lower degree of sense of coherence.

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