• 1
    Ruggeri ZM. Mechanisms initiating platelet thrombus formation. Thromb Haemost, 1997;78:611 6.
  • 2
    Pareti FI, Niiya K, McPherson JM, Ruggeri ZM. Isolation and characterization of two domains of human von Willebrand factor that interact with fibrillar collagen types I and III. J Biol Chem, 1987;262:13835 41.
  • 3
    Rand JH, Patel ND, Schwartz E, Zhou SL, Potter BJ. 150-kD von Willebrand factor binding protein extracted from human vascular subendothelium is type VI collagen. J Clin Invest, 1991;88:253 9.
  • 4
    Rand JH, Glanville RW, Wu XXet al. The significance of subendothelial von Willebrand factor. Thromb Haemost, 1997;78:445 50.
  • 5
    Moroi M, Jung SM, Nomura S, Sekiguchi S, Ordinas A, Diaz-Ricart M. Analysis of the involvement of the von Willebrand factor–glycoprotein Ib interaction in platelet adhesion to a collagen-coated surface under flow conditions. Blood, 1997;90:4413 24.
  • 6
    Savage B, Almus-Jacobs F, Ruggeri ZM. Specific synergy of multiple substrate–receptor interactions in platelet thrombus formation under flow. Cell, 1998;94:657 66.
  • 7
    Kehrel B. Platelet receptors for collagen. Platelets, 1995;6:11 6.
  • 8
    Alberio L & Dale GL. Flow cytometric analysis of platelet activation by different collagen types present in the vessel wall. Br J Haematol, 1998;102:1212 8.
  • 9
    Brass LF. The biochemistry of platelet activation. In: Hoffman R, Benz EJ, Shattil SJ, Furie B & Cohen HJ, editors. Hematology Basic Principles and Practice. New York: Churchill Livingstone; 1991. p.1176 97.
  • 10
    Kehrel B. Platelet–collagen interactions. Sem Thromb Hemost, 1995;21:123 9.
  • 11
    Sixma JJ, Van Zanten H, Huizinga EGet al. Platelet adhesion to collagen: an update. Thromb Haemost, 1997;78:434 8.
  • 12
    Moroi M & Jung SM. Platelet receptors for collagen. Thromb Haemost, 1997;78:439 44.
  • 13
    Watson SP & Gibbins JM. Collagen receptor signalling in platelets: extending the role of the ITAM. Immunol Today, 1998;19:260 4.
  • 14
    Barnes MJ, Knight CG, Farndale RW. The collagen–platelet interaction. Curr Opin Hematol, 1998;5:314 20.
  • 15
    Morton LF, Peachey AR, Barnes MJ. Platelet-reactive sites in collagens type I and type III. Evidence for separate adhesion and aggregatory sites. Biochem J, 1989;258:157 63.
  • 16
    Santoro SA, Walsh JJ, Staatz WD, Baranski KJ. Distinct determinants on collagen support α2β1 integrin-mediated platelet adhesion and activation. Cell Regul, 1991;2:905 13.
  • 17
    Barnes MJ, Knight CG, Farndale RW. The use of collagen-based model peptides to investigate platelet-reactive sequences in collagen. Biopolymers, 1996;40:383 97.
  • 18
    Knight CG, Morton LF, Onley DJet al. Identification in collagen type I of an integrin alpha2 beta1-binding site containing an essential GER sequence. J Biol Chem, 1998;273:33287 94.
  • 19
    Van Der Rest M & Garrone R. Collagen family of proteins. FASEB J, 1991;5:2814 23.
  • 20
    Williams BR, Gelman RA, Poppke DC, Piez KA. Collagen fibril formation: optimal in vitro conditions and preliminary kinetic results. J Biol Chem, 1978;253:6578 85.
  • 21
    Pischel KD, Bluestein HG, Woods VL. Platelet glycoproteins Ia, Ic, and IIa are physicochemically indistinguishable from the very late activation antigens adhesion-related proteins of lymphocytes and other cell types. J Clin Invest, 1988;81:505 13.
  • 22
    Kunicki TJ, Nugent DJ, Staats SJ, Orchekowski RP, Wayner EA, Carter WG. The human fibroblast class II extracellular matrix receptor mediates platelet adhesion to collagen and is identical to the platelet glycoprotein Ia-IIa complex. J Biol Chem, 1988;263:4516 9.
  • 23
    Santoro SA & Zutter MM. The α2β1 integrin: a collagen receptor on platelets and other cells. Thromb Haemost, 1995;74:813 21.
  • 24
    Takada Y & Hemler ME. The primary structure of the VLA-2/collagen receptor alpha 2 subunit (platelet GPIa): homology to other integrins and the presence of a possible collagen-binding domain. J Cell Biol, 1989;109:397 407.
  • 25
    Argraves WS, Suzuki S, Arai H, Thompson K, Pierschbacher MD, Ruoslathi E. Amino acid sequence of the human fibronectin receptor. J Cell Biol, 1987;105:1183 90.
  • 26
    Dickeson SK, Walsh JJ, Santoro SA. Contributions of the I and EF hand domains to the divalent cation-dependent collagen binding activity of the alpha2beta1 integrin. J Biol Chem, 1997;272:7661 8.
  • 27
    Kamata T, Puzon W, Takada Y. Identification of putative ligand binding sites within I domain of integrin alpha 2 beta 1 (VLA-2, CD49b/CD29). J Biol Chem, 1994;271:9659 63 [erratum: J Biol Chem, 1996;271:19008].
  • 28
    Tuckwell DS, Reid KB, Barnes MJ, Humphries MJ. The A-domain of integrin alpha 2 binds specifically to a range of collagens but is not a general receptor for the collagenous motif. Eur J Biochem, 1996;241:732 9.
  • 29
    Depraetere H, Wille C, Gansemans Yet al. The integrin alpha 2 beta 1 (GPIa/IIa) -I-domain inhibits platelet– collagen interaction. Thromb Haemost, 1997;77:981 5.
  • 30
    Chan BM & Hemler ME. Multiple functional forms of the integrin VLA-2 can be derived from a single alpha 2 cDNA clone: interconversion of forms induced by an anti-beta 1 antibody. J Cell Biol, 1993;120:537 43.
  • 31
    Takada Y & Puzon W. Identification of a regulatory region of integrin beta 1 subunit using activating and inhibiting antibodies. J Biol Chem, 1993;268:17597 601.
  • 32
    Nieuwenhuis HK, Akkerman JW, Houdijk WPW, Sixma JJ. Human blood platelets showing no response to collagen fail to express surface glycoprotein Ia. Nature, 1985;318:470 2.
  • 33
    Nieuwenhuis HK, Sakariassen KS, Houdijk WPW, Nievelstein PF, Sixma JJ. Deficiency of platelet membrane glycoprotein Ia associated with a decreased platelet adhesion to subendothelium: a defect in platelet spreading. Blood, 1986;68:692 5.
  • 34
    Kehrel B, Balleisen L, Kokott R, Mesters R, Stenzinger W, Clemetson KJ. Deficiency of intact thrombospondin and membrane glycoprotein Ia in platelets with defective collagen induced aggregation and spontaneous loss of the disorder. Blood, 1988;71:1074 8.
  • 35
    Deckmyn H, Chew SL, Vermylen J. Lack of platelet response to collagen associated with an autoantibody against glycoprotein Ia: a novel cause of acquired qualitative platelet dysfunction. Thromb Haemost, 1990;64:74 9.
  • 36
    Handa M, Watanabe K, Kawai Yet al. Platelet unresponsiveness to collagen: involvement of glycoprotein Ia-IIa (alpha 2 beta 1 integrin) deficiency associated with a myeloproliferative disorder. Thromb Haemost, 1995;73:521 8.
  • 37
    Santoro SA. Identification of a 160′000 dalton platelet membrane protein that mediates the initial divalent cation-dependent adhesion of platelets to collagen. Cell, 1986;46:913 20.
  • 38
    Staatz WD, Rajpara SM, Wayner EA, Carter WG, Santoro SA. The membrane glycoprotein Ia-IIa (VLA-2) complex mediates the Mg2+-dependent adhesion of platelet to collagen . J Biol Chem, 1989;108:1917 24.
  • 39
    Shadle PJ & Barondes SH. Adhesion of human platelets to immobilized trimeric collagen. J Cell Biol, 1982;95:361 5.
  • 40
    Saelman EUM, Nieuwenhuis HK, Hese KMet al. Platelet adhesion to collagen types I through VIII under conditions of stasis and flow is mediated by GPIa/IIa (α2β1-integrin) . Blood, 1994;83:1244 50.
  • 41
    Rosfjord EC, Maemura M, Johnson MDet al. Activation of protein kinase C by phorbol esters modulates alpha2beta1 integrin on MCF-7 breast cancer cells. Exp Cell Res, 1999;248:260 71.
  • 42
    Jung SM & Moroi M. Platelets interact with soluble and insoluble collagens through characteristically different reactions. J Biol Chem, 1998;273:14827 37.
  • 43
    Chung J, Wang XQ, Lindberg FP, Frazier WA. Thrombospondin-1 acts via IAP/CD47 to synergize with collagen in alpha2beta1-mediated platelet activation. Blood, 1999;94:642 8.
  • 44
    Kunicki TJ, Orchekowski R, Annis D, Honda Y. Variability of integrin α2β1 activity on human platelets. Blood, 1993;82:2693 703.
  • 45
    Coller BS, Beer JH, Scudder LE, Steinberg MH. Collagen–platelet interactions: evidence for a direct interaction of collagen with platelet GP Ia/IIa and an indirect interaction with platelet GP IIb/IIIa mediated by adhesive proteins. Blood, 1989;74:182 92.
  • 46
    Kritzik M, Savage B, Nugent DJ, Santoso S, Ruggeri ZM, Kunicki TJ. Nucleotide polymorphisms in the α2 gene define multiple alleles that are associated with differences in platelet α2β1 density. Blood, 1998;92:2382 8.
  • 47
    Kunicki TJ, Kritzik M, Annis DS, Nugent DJ. Hereditary variation in platelet integrin alpha 2 beta 1 density is associated with two silent polymorphisms in the alpha 2 gene coding sequence. Blood, 1997;89:1939 43.
  • 48
    Kiefel V, Santoso S, Katzmann B, Mueller-Eckhardt C. The Bra/Brb alloantigen system on human platelets. Blood, 1989;73:2219 23.
  • 49
    Moshfegh K, Wuillemin WA, Redondo Met al. Association of two silent polymorphisms of platelet glycoprotein Ia/IIa receptor with risk of myocardial infarction: a case-control study. Lancet, 1999;353:351 4.
  • 50
    Santoso S, Kunicki TJ, Kroll H, Haberbosch W, Gardemann A. Association of the platelet glycoprotein Ia C807T gene polymorphism with nonfatal myocardial infarction in younger patients. Blood, 1999;93:2449 53.
  • 51
    Carlsson LE, Santoso S, Spitzer C, Kessler C, Greinacher A. The alpha2 gene coding sequence T807/A873 of the platelet collagen receptor integrin alpha2beta1 might be a genetic risk factor for the development of stroke in younger patients. Blood, 1999;93:3583 6.
  • 52
    Di Paola J, Federici AB, Mannucci PMet al. Low platelet alpha2beta1 levels in type I von Willebrand disease correlate with impaired platelet function in a high shear stress system. Blood, 1999;93:3578 82.
  • 53
    Santoro SA. Platelet surface collagen receptor polymorphisms: variable receptor expression and thrombotic/ hemorrhagic risk. Blood, 1999;93:3575 7.
  • 54
    Clemetson KJ, McGregor JL, James E, Dechevanne M, Luscher EF. Characterization of the platelet membrane glycoprotein abnormalities in Bernard–Soulier syndrome and comparison with normal by surface-labeling techniques and high-resolution two-dimensional gel electrophoresis. J Clin Invest, 1982;70:304 11.
  • 55
    Sugiyama T, Okuma M, Ushikubi F, Sensaki S, Kanaji K, Uchino H. A novel platelet aggregating factor found in a patient with defective collagen-induced platelet aggregation and autoimmune thrombocytopenia. Blood, 1989;69:1712 20.
  • 56
    Moroi M, Jung SM, Okuma M, Shinmyozu K. A patient with platelet deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesion. J Clin Invest, 1989;84:1440 5.
  • 57
    Ryo R, Yoshida A, Sugano Wet al. Deficiency of P62, a putative collagen receptor, in platelets from a patient with defective collagen-induced platelet aggregation. Am J Hematol, 1992;39:25 31.
  • 58
    Arai M, Yamamoto N, Moroi M, Akamatsu N, Fukutane K, Tanoue K. Platelets with 10% of the normal amount of glycoprotein VI have an impaired response to collagen that results in a mild bleeding tendency. Br J Haematol, 1995;89:124 30.
  • 59
    Takahashi H, Hanano M, Moroi M, Shibata A. Platelet membrane glycoprotein VI (GPVI) is necessary for collagen-induced aggregation and adhesion and anti-GPVI antibody induces platelet aggregation: an evidence from a patient with systemic lupus erythematosus. Thromb Haemost, 1995;73:1197 (Abstract).
  • 60
    Moroi M, Okuma M, Jung SM. Platelet adhesion to collagen-coated wells: analysis of this complex process and a comparison with the adhesion to matrigel-coated wells. Biochim Biophys Acta, 1992;1137:1 9.
  • 61
    Nakamura T, Kambayashi J, Okuma M, Tandon NN. Activation of the GP IIb-IIIa complex induced by platelet adhesion to collagen is mediated by both alpha2beta1 integrin and GP VI. J Biol Chem, 1999;274:11897 903.
  • 62
    Moroi M, Jung SM, Shinmyozu K, Tomiyama Y, Ordinas A, Diaz-Ricart M. Analysis of platelet adhesion to a collagen-coated surface under flow conditions: the involvement of glycoprotein VI in the platelet adhesion. Blood, 1996;88:2081 92.
  • 63
    Kehrel B, Vierwille S, Clemetson KJet al. Glycoprotein VI is a major collagen receptor for platelet activation: it recognizes the platelet activating quaternary structure of collagen, whereas CD36, glycoprotein IIb/IIIa and von Willebrand factor do not. Blood, 1998;91:491 9.
  • 64
    Talle MA, Rao PE, Westberg Eet al. Patterns of antigenic expression on human monocytes as defined by monoclonal antibodies. Cell Immunol, 1983;78:83 99.
  • 65
    Daviet L & McGregor JL. Vascular biology of CD36: roles of this new adhesion molecule family in different disease states. Thromb Haemost, 1997;78:65 9.
  • 66
    Ware JA & Coller BS. Platelet morphology, biochemistry, and function. In: Beutler E, Lichtmann MA, Coller BS & Kipps TJ, editors. Williams Hematology. 5th ed. New York: McGraw-Hill; 1995. p.1161 201.
  • 67
    Tandon NN, Kralisz U, Jamison GA. Identification of glycoprotein IV (CD36) as a primary receptor for platelet-collagen adhesion. J Biol Chem, 1989;264:7576 83.
  • 68
    McGregor GL, Catimel B, Parmentier S, Clezardin P, Dechevanne M, Leung LL. Rapid purification and partial characterisation of human glycoprotein IIIb. Interaction with thrombospondin and its role in platelet aggregation. J Biol Chem, 1989;264:501 6.
  • 69
    Diaz-Ricart M, Tandon NN, Carretero M, Ordinas A, Bastida E, Jamieson G. Platelets lacking functional CD36 (glycoprotein IV) show reduced adhesion to collagen in flowing whole blood. Blood, 1993;82:491 6.
  • 70
    Yamamoto N, Ikeda H, Tandon NNet al. A platelet membrane glycoprotein (GP) deficiency in healthy blood donors: Naka- platelets lack detectable GPIV (CD36). Blood, 1990;76:1698 703.
  • 71
    Yamamoto N, Akamatsu N, Yamazaki H, Tanoue K. Normal aggregations of glycoprotein IV (CD36) -deficient platelets from seven healthy Japanese donors. Br J Haematol, 1992;81:86 92.
  • 72
    Daniel JL, Dangelmaier C, Strouse R, Smith JB. Collagen induces normal signal transduction in platelets deficient in CD36 (platelet glycoprotein IV). Thromb Haemost, 1994;71:353 6.
  • 73
    Saelman EU, Kehrel B, Hese KM, DeGroot PG, Sixma JJ, Nieuwenhuis HK. Platelet adhesion to collagen and endothelial cell matrix under flow conditions is not dependent on platelet glycoprotein IV. Blood, 1994;83:3240 4.
  • 74
    Kehrel B, Kronenberg A, Rauterberg Jet al. Platelets deficient in glycoprotein IIIb aggregate normally to collagens type I and III but not to collagen type V. Blood, 1993;82:3364 70.
  • 75
    Ooshima A. Collagen B-chain: increased proportion in human atherosclerosis. Science, 1981;213:666 8.
  • 76
    Chiang TM & Kang AH. Isolation and purification of collagen α1 (I) receptor from human platelet membrane. J Biol Chem, 1982;257:7581 6.
  • 77
    Chiang TM, Kang AH, Dale JB, Beachy EH. Immunochemical studies of the purified human platelet receptor for the α1 (I) -chain of chick skin collagen. J Immunol, 1984;133:872 6.
  • 78
    Chiang TM, Jin A, Kang AH. Platelet–collagen interaction. Inhibition by a monoclonal antibody raised against collagen receptor. J Immunol, 1987;139:887 92.
  • 79
    Chiang TM, Rinaldy A, Kang AH. Cloning, characterization, and functional studies of a non-integrin platelet receptor for type I collagen. J Clin Invest, 1997;100:514 21.
  • 80
    Chiang TM & Kang AH. A synthetic peptide derived from the sequence of a type I collagen receptor inhibits type I collagen-mediated platelet aggregation. J Clin Invest, 1997;100:2079 84.
  • 81
    Deckmyn E, Von Houtte E, Vermylen J. Disturbed platelet aggregation to collagen associated with an antibody against an 85/90 kD platelet glycoprotein in a patient with prolonged bleeding time. Blood, 1992;79:1466 71.
  • 82
    Brass LF, Manning DR, Cichowski K, Abrams CS. Signaling through G proteins in platelets: to the integrins and beyond. Thromb Haemost 1997;78:581 9.
  • 83
    Rhee SG & Bae YS. Regulation of phosphoinositide-specific phospholipase C isoenzymes. J Biol Chem, 1997;272:15045 8.
  • 84
    Blake RA, Schieven GL, Watson SP. Collagen stimulates tyrosine phosphorylation of phospholipase C-gamma 2 but not phospholipase C-gamma 1 in human platelets. FEBS Lett, 1994;353:212 6.
  • 85
    Daniel JL, Dangelmaier C, Smith JB. Evidence for a role for tyrosine phosphorylation of phospholipase C gamma 2 in collagen-induced platelet cytosolic calcium mobilization. Biochem J, 1994;302:617 22.
  • 86
    Smith JB, Dangelmaier C, Daniel JL. Elevation of c-AMP in human platelets inhibits thrombin- but not collagen-induced tyrosine phosphorylation. Biochem Biophys Res Commun, 1993;191:695 700.
  • 87
    Shattil SJ, Ginsberg MH, Brugge JS. Adhesive signaling in platelets. Curr Opin Cell Biol, 1994;6:695 704.
  • 88
    Yanaga F, Poole A, Asselin Jet al. Syk interacts with tyrosine-phosphorylated proteins in human platelets activated by collagen and cross-linking of the Fc gamma-IIA receptor. Biochem J, 1995;311:471 8.
  • 89
    Fujii C, Yanagi S, Sada K, Nagai K, Taniguchi T, Yamamaura H. Involvement of protein-tyrosine kinase p72Syk in collagen-induced signal transduction in platelets. Eur J Biochem, 1994;226:243 8.
    Direct Link:
  • 90
    Gibbins JM, Briddon S, Shutes Aet al. The p85 subunit of phosphatidylinositol 3-kinase associates with the Fc receptor γ-chain and linker for activation of T cells (LAT) in platelets stimulated by collagen and convulxin. J Biol Chem, 1998;273:34437 43.
  • 91
    Zhang W, Sloan-Lancaster J, Kitchen J, Trible RP, Samelson LE. LAT: the ZAP-70 tyrosine kinase substrate that links T Cell receptor to cellular activation. Cell, 1998;92:83 92.
  • 92
    Reth M. Antigen receptor tail clue. Nature, 1989;338:383 4.
  • 93
    Gibbins JM, Asselin J, Farndale R, Barnes M, Law C-L, Watson SP. Tyrosine phophorylation of the Fc receptor γ-chain in collagen stimulated platelets. J Biol Chem, 1996;271:18095 9.
  • 94
    Morton HC, Van Den Herik-Oudijk IE, Vossebeld Pet al. Functional association between the human myeloid immunoglobulin A Fc receptor (CD89) and FcR γ-chain. J Biol Chem, 1995;270:29781 7.
  • 95
    Takai T, Li M, Sylvestre D, Clynes R, Ravetch JV. FcR gamma chain deletion results in pleiotrophic effector cell defects. Cell, 1994;76:519 29.
  • 96
    Shiue L, Zoller MJ, Brugge JS. Syk is activated by phosphotyrosine-containing peptides representing the tyrosine-based activation motifs of the high affinity receptor for IgE. J Biol Chem, 1995;270:10498 502.
  • 97
    Van Vugt MJ, Heijnen AF, Capel PJet al. FcR gamma-chain is essential for both surface expression and function of human Fc gamma RI (CD64) in vivo. Blood, 1996;87:3593 9.
  • 98
    Poole A, Gibbins JM, Turner Met al. The Fc receptor γ-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen. EMBO, 1997;16:2333 41.
  • 99
    Morton LF, Hargreaves PG, Farndale RW, Young RD, Barnes MJ. Integrin α2β1-independent activation of platelets by collagen: collagen tertiary (triple helical) and quaternary (polymeric) structures are sufficient alone for activity . Biochem J, 1995;306:337 44.
  • 100
    Asselin J, Gibbins JM, Achinson Met al. A collagen-like peptide stimulates tyrosine phosphorylation of syk and phospholipase Cγ2 in platelets independent of the integrin α2β1. Blood, 1997;89:1235 42.
  • 101
    Ichinohe T, Takayama H, Ezumi Y, Yanagi S, Yamamura H, Okuma M. Cyclic AMP-insensitive activation of c-Src and Syk protein-tyrosine kinases through platelet membrane glycoprotein VI. J Biol Chem, 1995;270:28029 36.
  • 102
    Liebenhoff U, Brockmeier D, Presek P. Substrate affinity of the protein tyrosine kinase pp. 60c-src is increased on thrombin stimulation of human platelets. Biochem J, 1993;295:41 8.
  • 103
    Clark EA, Shattil SJ, Ginsberg MH, Bolen J, Brugge JS. Regulation of the protein tyrosine kinase pp. 72syk by platelet agonists and the integrin alpha IIb beta 3. J Biol Chem, 1994;269:28859 64.
  • 104
    Ichinohe T, Takayama H, Ezumi Yet al. Collagen-stimulated activation of Syk but not c-Src is severly compromised in human platelets lacking membrane glycoprotein VI. J Biol Chem, 1997;272:63 8.
  • 105
    Gibbins JM, Okuma M, Farndale R, Barnes M, Watson SP. Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor γ-chain. FEBS Lett, 1997;413:255 9.
  • 106
    Tsuji M, Ezumi Y, Arai M, Takayama H. A novel association of Fc receptor γ-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets. J Biol Chem, 1997;272:23528 31.
  • 107
    Polgár J, Clemetson JM, Kehrel BEet al. Platelet activation and signal transduction by convulxin, a C-type lectin from crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor. J Biol Chem, 1997;272:13576 83.
  • 108
    Ezumi Y, Shindoh K, Tsuji M, Takayama H. Physical and functional association of the Src famiy kinases Fyn and Lyn with the collagen receptor glycoprotein VI-Fc receptor γ chain complex on human platelets. J Exp Med, 1998;188:267 76.
  • 109
    Hanke JH, Gardner JP, Dow RLet al. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and Fyn-dependent T cell activation. J Biol Chem, 1996;271:695 701.
  • 110
    Briddon SJ & Watson SP. Evidence for the involvement of p59fyn and p53/56lyn in collagen receptor signalling in human platelets. Biochem J, 1999;338:203 9.
  • 111
    Clements JL, Lee JR, Gross Bet al. Fetal hemorrhage and platelet dysfunction in SLP-76-deficient mice. J Clin Invest, 1999;103:19 25.
  • 112
    Jackman JK, Motto DG, Sun Qet al. Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells. J Biol Chem 1995;270:7029 32.
  • 113
    Yablonski D, Kuhne MR, Kadlecek T, Weiss A. Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76- deficient T cell. Science, 1998;281:413 6.
  • 114
    Clements JL, Yang B, Ross-Barta SEet al. Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development. Science, 1998;281:416 9.
  • 115
    Pivniouk V, Tsitsikov E, Swinton P, Rathbun G, Alt FW, Geha RS. Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76. Cell, 1998;94:229 38.
  • 116
    Gross BS, Lee JR, Clements JLet al. Tyrosine phosphorylation of SLP-76 is downstream of Syk following stimulation of the collagen receptor in platelets. J Biol Chem, 1999;274:5963 71.
  • 117
    Rittenhouse SE. Phosphoinositide 3-kinase activation and platelet function. Blood, 1996;88:4401 14 [erratum: Blood, 1997;89:3075].
  • 118
    Keely PJ & Parise LV. The α2β1 integrin is a necessary co-receptor for collagen-induced aktivation of syk and the subsequent phosphorylation of phospholipase Cγ2 in platelets . J Biol Chem, 1996;271:26668 76.
  • 119
    Kamiguti AS, Markland FS, Zhou Q, Laing GD, Theakston RDG, Zuzel M. Proteolytic cleavage of the β1 subunit of platelet α2β1 integrin by the metalloproteinase jararhagin compromises collagen-stimulated phosphorylation of pp. 72syk. J Biol Chem, 1997;272:32599 605.
  • 120
    Kelton JG, Sheridan D, Santos Aet al. Heparin-induced thrombocytopenia: laboratory studies. Blood, 1988;72:925 30.
  • 121
    Sullam PM, Hyun WC, Szollosi J, Dong J, Foss WM, Lopez JA. Physical proximity and functional interplay of the glycoprotein Ib-IX-V complex and the Fc receptor FcgammaRIIA on the platelet plasma membrane. J Biol Chem, 1998;273:5331 6.
  • 122
    Huang MM, Bolen JB, Barnwell JW, Shattil SJ, Brugge JS. Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets. Proc Natl Acad Sci USA, 1991;88:7844 8.
  • 123
    Aiken ML, Ginsberg MH, Byers-Ward V, Plow EF. Effects of OKM5, a monoclonal antibody to glycoprotein IV, on platelet aggregation and thrombospondin surface expression. Blood, 1990;76:2501 9.
  • 124
    Trelstad R & Carvalho A. Type IV and type ‘A-B’ collagens do not elicit platelet aggregation or the serotonin release reaction. J Lab Clin Med, 1979;93:499 504.
  • 125
    Chiang TM, Seyer JM, Kang AH. Collagen–platelet interaction: separate receptors sites for types I and III collagen. Thromb Res, 1993;71:443 56.
  • 126
    Huang TF, Liu CZ, Yang SH. Aggretin, a novel platelet-aggregation inducer from snake (Calloselasma rhodostoma) venom, activates phospholipase C by acting as a glycoprotein Ia/IIa agonist. Biochem J, 1995;309:1021 7.
  • 127
    Asselin J, Knight CG, Farndale RW, Barnes MJ, Watson SP. Monomeric (glycine-proline-hydroxyproline) 10 repeat sequence is a partial agonist of the platelet collagen receptor glycoprotein VI. Biochem J, 1999;339:413 8.
  • 128
    Knight CG, Morton LF, Onley DJet al. Collagen–platelet interaction: Gly-Pro-Hyp is uniquely specific for platelet Gp VI and mediates platelet activation by collagen. Cardiovasc Res, 1999;41:450 7.
  • 129
    Clemetson JM, Polgar J, Magnenat E, Wells TNC, Clemetson KJ. The platelet collagen receptor glycoprotein VI is a member fo the immunoglobulin superfamily closely related to Fc alpha R and the natural killer receptors. J Biol Chem, 1999;274:29019 24.