Oxidative stress in symptom-free HCV carriers: relation with ALT flare-up
Version of Record online: 9 OCT 2008
European Journal of Clinical Investigation
Volume 31, Issue 1, pages 54–63, January 2001
How to Cite
Vendemiale, G., Grattagliano, I., Portincasa, P., Serviddio, G., Palasciamo, G. and Altomare, E. (2001), Oxidative stress in symptom-free HCV carriers: relation with ALT flare-up. European Journal of Clinical Investigation, 31: 54–63. doi: 10.1046/j.1365-2362.2001.00747.x
- Issue online: 9 OCT 2008
- Version of Record online: 9 OCT 2008
- Received 29 February 2000; accepted 22 July 2000
- chronic hepatitis C;
- oxidative balance
The reason why some hepatitis C virus carriers with normal aminotransferase activity present, during time, an activation of the disease, is unknown. The aim of this study was to assess the oxidative balance in such patients and to evaluate its possible role on the severity of disease.
Materials and methods
Histology, glutathione and malondialdehyde were determined in the liver of 30 HCV-RNA positive patients with persistently normal aminotransferase. Patients were followed-up for 18 months with plasmatic determinations of aminotransferase, ferritin, glutathione, malondialdehyde, carbonyl and sulphydryl protein levels (every 2 months) and serum HCV-RNA (every 3 months).
Four subjects had normal histology, whereas the remaining 26 showed mild/moderate chronic hepatitis. Hepatic glutathione and malondialdehyde concentrations were normal in 16 patients and clearly altered in the other 14. The hepatic redox state did not correlate with histology whereas it correlated with plasmatic oxidative markers. During the study, aminotransferase flared up in 11 patients, 9 of these (82%) having at enrolment an altered hepatic oxidative balance. Patients with aminotransferase elevation showed increased blood indices of oxidative stress, which occurred earlier than aminotransferase flare-ups. No oxidative stress was observed in the remaining subjects.
This study suggests that symptom-free HCV carriers with impaired redox state have a higher risk of aminotransferase flare-up; therefore the impaired oxidative balance may have a prognostic significance on disease activity.