1744-313X/asset/cover.gif?v=1&s=8f5c80fe909e37c3dd7499797c5e3a42db0f93de "European Journal of Immunogenetics")
INSERM U396, Hôpital St Louis, Paris, France,
1744-313X/asset/IJI_centre.gif?v=1&s=3eff60c8abbe622ba8b4a6eede6030ce33ad8b65)
Mitochondrial DNA polymorphism in the Vietnamese population
Article first published online: 25 DEC 2001
DOI: 10.1046/j.1365-2370.1999.00184.x
Additional Information
How to Cite
Ivanova, R., Astrinidis, A., Lepage, V., Djoulah, S., Wijnen, E., Vu-Trieu, A. N., Hors, J. and Charron, D. (1999), Mitochondrial DNA polymorphism in the Vietnamese population. European Journal of Immunogenetics, 26: 417–422. doi: 10.1046/j.1365-2370.1999.00184.x
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INSERM U396, Hôpital St Louis, Paris, France,
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Laboratoire d’Immunologie et d’Histocompatibilite, Hôpital St Louis, Paris, France,
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Department of Genetics, Development and Molecular Biology, School of Biology, Aristotle University of Thessaloniki, 54006 Thessaloniki, Greece,
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Faculty of Technology and Science, Etten-Leur, Pays-Bas, and
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Department of Immunology and Physiopathology, Medical College of Hanoi, Vietnam.
Publication History
- Issue published online: 25 DEC 2001
- Article first published online: 25 DEC 2001
- Received 9 April 1999; revised 21 June 1999;accepted 14 July 1999
- Abstract
- Article
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- Cited By
Abstract
The mitochondrial DNA variation was screened in a sample of 50 unrelated individuals of the Vietnamese population originating from Hanoi. A combination of long and standard PCR and restriction endonuclease digests with the enzymes HpaI, BamHI, HaeII, MspI, AvaII and HincII were used to reveal mtDNA variation. Twenty enzyme morphs were detected, three of which (HaeII-13Viet, MspI-19Viet and MspI-20Viet) are new and are produced by a single mutational event in already known enzyme morphs. Ten already known and four new mitotypes [93Viet (1-1-2-4-1), 94Viet (2-1-13Viet-1-1), 95Viet (2-1-13Viet-19Viet-1) and 96Viet (1-1-2–20Viet-12)] were found in the Vietnamese population. The 9-bp deletion occurring in the COII/tRNALys region of the mitochondrial genome was also analysed and 10 samples were found to have this deletion. The comparison of the Vietnamese with other East Asian populations showed a close genetic relationship of the population under investigation with other Orientals. However, the Vietnamese population can be differentiated by the significantly higher frequency of the enzyme morph HincII-5 and by seven new markers. These results strongly support the hypothesis of a dual ethnic origin of the Vietnamese population from the Chinese and Thai–Indonesian populations based on HLA markers and linguistic evidence.