CD80 (B7-1) and CD86 (B7-2) genes and genetic susceptibility to coeliac disease


  • N. Woolley,

  • P. Holopainen,

  • C. Bourgain,

  • K. Mustalahti,

  • P. Collin,

  • M. Mäki,

  • J. Partanen

  • Department of Tissue Typing, Finnish Red Cross Blood Transfusion Service, Helsinki, Finland,

  •  INSERM U535, Kremlin-Bicetre, France, and

  •  Institute of Medical Technology and Department of Pediatrics, University of Tampere, Tampere, Finland.

Jukka Partanen, FRC Blood Transfusion Service, Kivihaantie 7, 00310 Helsinki, Finland. Tel: 358 9 5801298; Fax: 358 9 5801429; E-mail:


The role of the costimulatory molecules B7-1 (CD80) and B7-2 (CD86) in T-cell activation makes them good candidates for coeliac disease susceptibility genes. We conducted a genetic linkage study of the CD80/86 gene region in the general Finnish population and in a local subisolate. No linkage was found in either population.