Chromatin assembly factors: a dual function in nucleosome formation and mobilization?

Authors

  • Takashi Ito,

    1. Department of Biology, 0347, and Centre for Molecular Genetics, University of California, San Diego, Pacific Hall, room 2216, 9500 Gilman Drive, La Jolla, CA 92093-0347, USA
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  • Jessica K. Tyler,

    1. Department of Biology, 0347, and Centre for Molecular Genetics, University of California, San Diego, Pacific Hall, room 2216, 9500 Gilman Drive, La Jolla, CA 92093-0347, USA
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  • James T. Kadonaga

    1. Department of Biology, 0347, and Centre for Molecular Genetics, University of California, San Diego, Pacific Hall, room 2216, 9500 Gilman Drive, La Jolla, CA 92093-0347, USA
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James T. Kadonaga E-mail: jkadonaga@ucsd.edu

Abstract

Chromatin assembly is a process that interfaces DNA replication, gene expression and progression through the cell cycle, and it is therefore critically involved in many important biological phenomena. This brief review provides a general background to the study of chromatin assembly, as well as an overview of putative chromatin assembly factors. Interestingly, recent data suggest that the ATP-utilizing chromatin assembly factor, ACF, functions not only in nucleosome formation, but also in the ATP-dependent remodelling of chromatin that facilitates DNA-utilizing processes, such as transcription, replication, recombination, and repair.

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