• 1
    Allfrey, V.G., Faulkner, R., Mirsky, A.E. (1964) Acetylation and methylation of histones and their possible role in the regulation of RNA synthesis. Proc. Natl. Acad. Sci. USA 51, 786794.
  • 2
    Bannister, A.J. & Kouzarides, T. (1996) The CBP co-activator is a histone acetyltransferase. Nature 384, 641643.
  • 3
    Borrow, J., Stanton, V.P. Jr, Andresen, J.M., et al. (1996) The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein. Nat. Genet. 14, 3341.
  • 4
    Braunstein, M., Sobel, R.E., Allis, C.D., Turner, B.M., Broach, J.R. (1996) Efficient transcriptional silencing in Saccharomyces cerevisiae requires a heterochromatin histone acetylation pattern. Mol. Cell. Biol. 16, 43494356.
  • 5
    Brownell, J.E., Zhou, J., Ranalli, T., et al. (1996) Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation. Cell 84, 843851.
  • 6
    Chen, H., Lin, R.J., Schiltz, R.L., et al. (1997) Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell 90, 569580.
  • 7
    Doenecke, D. & Gallwitz, D. (1982) Acetylation of histones in nucleosomes . Mol. Cell. Biochem. 44, 113128.
  • 8
    Ehrenhofer-Murray, A.E., Rivier, D.H., Rine, J. (1997) The role of Sas2, an acetyltransferase homologue of Saccharomyces cerevisiae, in silencing and ORC function. Genetics 145, 923934.
  • 9
    Grant, P.A., Duggan, L., Côté, J., et al. (1997) Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex. Genes Dev. 11, 16401650.
  • 10
    Grant, P.A., Schieltz, D., Pray-Grant, M.G. , et al. (1998) A subset of TAFIIs are integral components of the SAGA complex required for nucleosome acetylation and transcriptional stimulation. Cell 94, 4553.
  • 11
    Grunstein, M. (1997) Histone acetylation in chromatin structure and transcription. Nature 389, 349352.DOI: 10.1038/38664
  • 12
    Gu, W. & Roeder, R.G. (1997) Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 90, 595606.
  • 13
    Hilfiker, A., Hilfiker-Kleiner, D., Pannuti, A., Lucchesi, J.C. (1997) mof, a putative acetyl transferase gene related to the Tip60 and MOZ human genes and to the SAS genes of yeast, is required for dosage compensation in Drosophila. EMBO J. 16, 20542060.DOI: 10.1093/emboj/16.8.2054
  • 14
    Imhof, A., Yang, X.-J., Ogryzko, V.V., Nakatani, Y., Wolffe, A.P., Ge, H. (1997) Acetylation of general transcription factors by histone acetyltransferases. Curr. Biol. 7, 689692.
  • 15
    Kamine, J., Elangovan, B., Subramanian, T., Coleman, D., Chinnadurai, G. (1996) Identification of a cellular protein that specifically interacts with the essential cysteine region of the HIV-1 Tat transactivator. Virology 216, 357366.DOI: 10.1006/viro.1996.0071
  • 16
    Karas, M. & Bahr, U. (1991) Matrix-assisted laser desorption ionization mass spectrometry. Mass Spect. Rev. 10, 335357.
  • 17
    Kimura, A. & Horikoshi, M. (1998) How do histone acetyltransferases select lysine residues in core histones? FEBS Lett. 431, 131133.DOI: 10.1016/S0014-5793(98)00752-2
  • 18
    Kleff, S., Andrulis, E.D., Anderson, C.W., Sternglanz, R. (1995) Identification of a gene encoding a yeast histone H4 acetyltransferase. J. Biol. Chem. 270, 2467424677.
  • 19
    Kuo, M.-H., Brownell, J.E., Sobel, R.E., et al. (1996) Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines. Nature 383, 269272.
  • 20
    Kuo, M.-H., Zhou, J., Jambeck, P., Churchill, M.E.A., Allis, C.D. (1998) Histone acetyltransferase activity of yeast Gcn5p is required for the activation of target genes in vivo. Genes Dev. 12, 627639.
  • 21
    Lu, L., Berkey, K.A., Casero, R.A. Jr (1996) RGFGIGS is an amino acid sequence required for acetyl coenzyme A binding and activity of human spermidine/spermine N1 acetyltransferase. J. Biol. Chem. 271, 1892018924.
  • 22
    Lusser, A., Brosch, G., Loidl, A., Haas, H., Loidl, P. (1997) Identification of maize histone deacetylase HD2 as an acidic nucleolar phosphoprotein. Science 277, 8891.DOI: 10.1126/science.277.5322.88
  • 23
    Marvin, K.W., Yau, P., Bradbury, E.M. (1990) Isolation and characterization of acetylated histones H3 and H4 and their assembly into nucleosomes. J. Biol. Chem. 265, 1983919847.
  • 24
    Mizzen, C.A., Yang, X.-J., Kokubo, T., et al. (1996) The TAFII250 subunit of TFIID has histone acetyltransferase activity. Cell 87, 12611270.
  • 25
    Ogryzko, V.V., Kotani, T., Zhang, X. , et al. (1998) Histone-like TAFs within the PCAF histone acetylase complex. Cell 94, 3544.
  • 26
    Ogryzko, V.V., Schiltz, R.L., Russanova, V., Howard, B.H., Nakatani, Y. (1996) The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell 87, 953959.
  • 27
    Parthun, M.R., Widom, J., Gottschling, D.E. (1996) The major cytoplasmic histone acetyltransferase in yeast: links to chromatin replication and histone metabolism. Cell 87, 8594.
  • 28
    Puri, P.L., Sartorelli, V., Yang, X.-J., et al. (1997) Differential roles of p300 and PCAF acetyltransferases in muscle differentiation. Mol. Cell 1, 3545.
  • 29
    Reifsnyder, C., Lowell, J., Clarke, A., Pillus, L. (1996) Yeast SAS silencing genes and human genes associated with AML and HIV–1 Tat interactions are homologous with acetyltransferases. Nat. Genet. 14, 4249.
  • 30
    Rundlett, S.E., Carmen, A.A., Kobayashi, R., Bavykin, S., Turner, B.M., Grunstein, M. (1996) HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription. Proc. Natl. Acad. Sci. USA 93, 1450314508.
  • 31
    Smith, E.R., Eisen, A., Gu, W., et al. (1998) ESA1 is a histone acetyltransferase that is essential for growth in yeast. Proc. Natl. Acad. Sci. USA 95, 35613565.
  • 32
    Spencer, T.E., Jenster, G., Burcin, M.M., et al. (1997) Steroid receptor coactivator-1 is a histone acetyltransferase. Nature 389, 194198.DOI: 10.1038/38304
  • 33
    Taunton, J., Hassig, C.A., Schreiber, S.L. (1996) A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 272, 408411.
  • 34
    Thorne, A.W., Kmiciek, D., Mitchelson, K., Sautiere, P., Crane-Robinson, C. (1990) Patterns of histone acetylation. Eur. J. Biochem. 193, 701713.
  • 35
    Turner, B.M., Birley, A.J., Lavender, J. (1992) Histone H4 isoforms acetylated at specific lysine residues define individual chromosomes and chromatin domains in Drosophila polytene nuclei. Cell 69, 375384.
  • 36
    Wade, P.A., Pruss, D., Wolffe, A.P. (1997) Histone acetylation: chromatin in action. Trends Biochem. Sci. 22, 128132.DOI: 10.1016/S0968-0004(97)01016-5
  • 37
    Yamamoto, T. & Horikoshi, M. (1997) Novel substrate specificity of the histone acetyltransferase activity of HIV-1-Tat interactive protein Tip60. J. Biol. Chem. 272, 3059530598.
  • 38
    Yang, X.-J., Ogryzko, V.V., Nishikawa, J., Howard, B.H., Nakatani, Y. (1996) A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature 382, 319324.
  • 39
    Yip, T.-T. & Hutchens, T.W. (1992) Mapping and sequence-specific identification of phosphopeptides in unfractionated protein digest mixtures by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. FEBS Lett. 308, 149153.
  • 40
    Zhang, W., Bone, J.R., Edmondson, D.G., Turner, B.M., Roth, S.Y. (1998) Essential and redundant functions of histone acetylation revealed by mutation of target lysines and loss of the Gcn5p acetyltransferase. EMBO J. 17, 31553167.DOI: 10.1093/emboj/17.11.3155