Molecular basis of tissue-specific gene expression mediated by the Runt domain transcription factor PEBP2/CBF

Authors

  • Yoshiaki Ito

    1. Laboratory of Cell Regulation, Department of Viral Oncology, Institute for Virus Research, Kyoto University, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
    Search for more papers by this author

Yoshiaki Ito E-mail: yito@ virus.kyoto-u.ac.jp

Abstract

The Runt domain transcription factor PEBP2/CBF is a heterodimer of α and β subunits. Of the three mammalian α subunit genes, which are homologues of the Drosophila gene runt, PEBP2αA/CBFA1 and PEBP2αB/AML1 are critical regulators of osteogenesis and haematopoiesis, respectively. A unique functional interaction between PEBP2αB/AML1 and Ets-1 was recently observed, and provides a clear example of context-dependent transcriptional regulation. An elaborate mechanism of cooperation between the two factors may represent a basis for tissue-specific gene expression, which is thought to be achieved by combinations of specific sets of transcription factors unique to each cell lineage or stage of differentiation. A possible molecular basis for the critical role(s) played by PEBP2/CBF in tissue determination is discussed in light of these observations.

Ancillary