Molecular mechanism of a cross-talk between oestrogen and growth factor signalling pathways

Authors

  • Shigeaki Kato,

    1. The Institute of Molecular and Celluar Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan,
    2. CREST, Japan Science and Technology, 4-1-8 Honcho, Kawaguchi-shi, Saitama 332-0012, Japan,
    Search for more papers by this author
  • Yoshikazu Masuhiro,

    1. The Institute of Molecular and Celluar Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan,
    Search for more papers by this author
  • Michiko Watanabe,

    1. The Institute of Molecular and Celluar Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan,
    Search for more papers by this author
  • Yoko Kobayashi,

    1. The Institute of Molecular and Celluar Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan,
    Search for more papers by this author
  • Ken-ichi Takeyama,

    1. The Institute of Molecular and Celluar Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan,
    Search for more papers by this author
  • Hideki Endoh,

    1. The Institute of Molecular and Celluar Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan,
    2. Molecular Medicine Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical, Tsukuba, Ibaraki 308-8585, Japan
    Search for more papers by this author
  • Junn Yanagisawa

    1. The Institute of Molecular and Celluar Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan,
    2. CREST, Japan Science and Technology, 4-1-8 Honcho, Kawaguchi-shi, Saitama 332-0012, Japan,
    Search for more papers by this author

Shigeaki Kato E-mail: uskato@mail.ecc.u-tokyo.ac.jp

Abstract

Oestrogen (E2) plays significant roles in variety of biological events such as the development and maintenance of female reproductive organs, bone and lipid metabolisms. More recently, from study of knock-out mice deficient in oestrogen receptor (ER) α and ERβ it turned out that normal spermatogenesis requires the E2 actions. Furthermore, this female steroid hormone is also well known to be deeply involved in many pathophysiological events such as osteoporosis and cancer development in female reproductive organs. It is particularly well known that most breast cancer is dependent on E2 in its development. Such E2 actions are thought to be mediated through two subtypes of ERs. Growth factors have been shown to synergize in this E2 signalling pathway, although the actual molecular mechanism largely remains unknown.

Recently, we found that the MAP kinase activated by growth factors phosphorylates the Ser118 residue of the human ERα A/B domain and this phosphorylation potentiates the N-terminal transactivation function (AF-1) of human ERα, indicating the possible molecular mechanism of a novel cross-talk between E2 and growth factor signalling pathways. More recently, we have identified a coactivator associating with the hERα AF-1 in a MAPK-mediated phosphorylation-dependent manner. In this review, the molecular mechanism of this cross-talk is discussed in terms of the transactivation function of ERs, and their coactivators.

Ancillary