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  • Akiyama, S., Katagiri, T., Namiki, M., et al. (1997) Constitutively active BMP type I receptors transduce BMP-2 signals without the ligand in C2C12 myoblasts. Exp. Cell Res. 235, 362369.
  • Arnold, H.-H. & Winter, B. (1998) Muscle differentiation: more complexity to the network of myogenic regulators. Curr. Opin. Genet. Dev. 8, 539544.
  • Asahina, I., Sampath, T.K., Nishimura, I. & Hauschka, P.V. (1993) Human osteogenic protein-1 induces both chondroblastic and osteoblastic differentiation of osteoprogenitor cells derived from newborn rat calvaria. J. Cell Biol. 123, 921933.
  • Benezra, R., Davis, R.L., Lockshon, D., Turner, D.L. & Weintraub, H. (1990) The protein Id: a negative regulator of helix-loop-helix DNA binding proteins. Cell 61, 4959.
  • Buckingham, M. (2001) Skeletal muscle formation in vertebrates. Curr. Opin. Genet. Dev. 11, 440448.
  • Celeste, A., Iannazzi, J.A., Taylor, R.C., et al. (1990) Identification of transforming growth factor β family members present in bone-inductive protein purified from bovine bone. Proc. Natl. Acad. Sci. USA 87, 98439847.
  • Clement, J.H., Marr, N., Meissner, A., et al. (2000) Bone morphogenetic protein 2 (BMP-2) induces sequential changes of Id gene expression in the breast cancer cell line MCF-7. J. Cancer Res. Clin. Oncol. 126, 271279.
  • Dennler, S., Itoh, S., Vivien, D., Ten Dijke, P., Huet, S. & Gauthier, J.-M. (1998) Direct binding of Smad3 and Smad4 to critical TGF β-inducible elements in the promoter of human plasminogen inhibitor-type 1 gene. EMBO J. 17, 30913100.
  • Ebisawa, T., Tada, K., Kitajima, I., et al. (1999) Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation. J. Cell Sci. 112, 35193527.
  • Feng, X.-H., Zhang, Y., Wu, R.-Y. & Derynck, R. (1998) The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGF-β-induced transcriptional activation. Genes Dev. 12, 21532163.
  • Fujii, M., Takeda, K., Imamura, T., et al. (1999) Roles of bone morphogenetic protein type I receptors and Smad proteins in osteoblast and chondroblast differentiation. Mol. Biol. Cell 10, 38013813.
  • Hata, A., Seoane, J., Lagna, G., Montalvo, E., Hemmati-Brivanlou, A. & Massague, J. (2000) OAZ. uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways. Cell 100, 229240.
  • Hayashi, H., Abdollah, S., Qiu, Y., et al. (1997) The MAD-related protein Smad7 associates with the TGFβ receptor and functions as an antagonist of  TGFβ signaling. Genes Dev. 89, 11651173.
  • Hogan, B.L.M. (1996) Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes Dev. 10, 15801594.
  • Hollnagel, A., Oehlmann, V., Heymer, J., Rüther, U. & Nordheim, A. (1999) Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells. J. Biol. Chem. 274, 1983819845.
  • Imamura, T., Takase, M., Nishihara, A., et al. (1997) Smad6 inhibits signaling by the TGF-β superfamily. Nature 389, 622626.
  • Ishida, W., Hamamoto, T., Kusanagi, K., et al. (2000) Smad6 is a Smad1/5-induced Smad inhibitor: characterization of bone morphogenetic protein-responsive element in the mouse Smad6 promoter. J. Biol. Chem. 275, 60756079.
  • Iwasaki, S., Iguchi, M., Watanabe, K., Hoshino, R., Tsujimoto, M. & Kohno, M. (1999) Specific activation of the p38 mitogen-activated protein kinase signaling pathway and induction of neurite outgrowth in PC12 cells by bone morphogenetic protein-2. J. Biol. Chem. 274, 2650326510.
  • Janknecht, R., Wells, N.J. & Hunter, T. (1998) TGF-β-stimulated cooperation of Smad proteins with the coactivators CBP/p300. Genes Dev. 12, 21142119.
  • Jonk, L.J., Itoh, S., Heldin, C.-H., Ten Dijke, P. & Kruijer, W. (1998) Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-b, activin, and bone morphogenetic protein-inducible enhancer. J. Biol. Chem. 273, 2114521152.
  • Katagiri, T., Akiyama, S., Namiki, M., et al. (1997) Bone morphogenetic protein-2 inhibits terminal differentiation of myogenic cells by suppressing the transcriptional activity of MyoD and myogenin. Exp. Cell Res. 230, 342351.
  • Katagiri, T., Yamaguchi, A., Ikeda, T., et al. (1990) The non-osteogenic mouse pluripotent cell line, C3H10T1/2, is induced to differentiate into osteoblastic cells by recombinant human bone morphogenetic protein-2. Biochem. Biophys. Res. Commun. 172, 295299.
  • Katagiri, T., Yamaguchi, A., Komaki, M., et al. (1994) Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage. J. Cell Biol. 127, 17551766.
  • Kawabata, M., Imamura, T. & Miyazono, K. (1998) Signal transduction by bone morphogenetic proteins. Cytokine Growth Factor Rev. 9, 4961.
  • Kim, J., Johnson, K., Chen, H.J., Carroll, S. & Laughton, A. (1997) Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic. Nature 388, 304308.
  • Kingsley, D.M. (1994) The TGF-β superfamily: new members, new receptors, and new genetic tests of function in different organisms. Genes Dev. 8, 133146.
  • Kingsley, D.M., Bland, A.E., Grubber, J.M., et al. (1992) The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGF β superfamily. Cell 71, 399410.
  • Korchynski, O. & Ten Dijke, P. (2002) Identification and functional characterization of distinct critically important bone morphogenetic protein-specific responses elements in the Id1 promoter. J. Biol. Chem. 277, 48834891.
  • Lopez-Rovira, T., Chalaux, E., Massague, J., Rosa, J.L. & Ventura, F. (2002) Direct binding of Smad1 and Smad4 to two distinct motifs mediated bone morphogenetic protein-specific transcriptional activation of Id1 gene. J. Biol. Chem. 277, 31763185.
  • Ludolph, D.C. & Konieczny, S.F. (1995) Transcription factor families: muscling in on the myogenic program. FASEB J. 9, 15951604.
  • Luyten, F.P., Cunningham, N.S., Ma, S., et al. (1989) Purification and partial amino acid sequence of osteogenin, a protein initiating bone differentiation. J. Biol. Chem. 264, 1337713380.
  • Maeno, M., Ong, R.C., Suzuki, A., Ueno, N. & Kung, H.-F. (1994) A truncated bone morphogenetic protein 4 receptor alters the fate of ventral mesoderm to dorsal mesoderm: roles of animal pole tissue in the development of ventral mesoderm. Proc. Natl. Acad. Sci. USA 91, 1026010264.
  • Massague, J. (2000) How cells read TGF-β signals. Nat. Rev. Mol. Cell. Biol. 1, 169178.
  • Massague, J. & Chen, Y.-G. (2000) Controlling TGF-β signaling. Genes Dev. 14, 627644.
  • Miyazono, K. (1999) Signal transduction by bone morphogenetic protein receptors: functional roles of Smad proteins. Bone 25, 9193.
  • Molkentin, J.D. & Olson, E. (1996) Combinational control of muscle development by basic helix-loop-helix and MADS-box transcription factors. Proc. Natl. Acad. Sci. USA 93, 93669373.
  • Nakao, A., Afrakhte, M., Moren, A., et al. (1997) Identification of Smad7, a TGF β-inducible antagonist of TGF-β signaling. Nature 389, 631635.
  • Namiki, M., Akiyama, S., Katagiri, T., et al. (1997) A kinase domain-truncated type I receptor blocks bone morphogenetic protein-2-induced signal transduction in C2C12 myoblasts. J. Biol. Chem. 272, 2204622052.
  • Nishihara, A., Hanai, J.I., Okamoto, N., et al. (1998) Role of p300, a transcriptional coactivator, in signaling of  TGF-β. Genes Cells 3, 613623.
  • Nishimura, R., Kato, Y., Chen, D., Harris, S.E., Mundy, G.R. & Yoneda, T. (1998) Smad5 and DPC4 are key Molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12. J. Biol. Chem. 273, 18721879.
  • Perry, R.L.S. & Rudnicki, M.A. (2000) Molecular mechanisms regulating myogenic determination and differentiation. Front. Biosci. 5, d750767.
  • Pouponnot, C., Jayaraman, L. & Massague, J. (1998) Physical and functional interaction of SMADs and p300/CBP. J. Biol. Chem. 273, 2286522868.
  • Raftery, L. & Sutherland, D.J. (1999) TGF-β family signal transduction in Drosophila development. Dev. Biol. 210, 251268.
  • Reddi, A.H. (2001) Bone morphogenetic proteins: from basic to clinical applications. J. Bone Joint Surg. Am. 83A(Suppl. 1), S1S6.
  • Sakou, T. (1998) Bone morphogenetic proteins; from basic studies to clinical approaches. Bone 22, 591603.
  • Sampath, T.K., Coughlin, J.E., Whetstone, R.M., et al. (1990) Bovine osteogenic protein is composed of dimmers of OP-1 and BMP-2A, two members of the transforming growth factor-β superfamily. J. Biol. Chem. 265, 1319813205.
  • Sampath, T.K., Maliakal, J.C., Hauschka, P.V., et al. (1992) Recombinant human osteogenic protein-1 (hOP-1) induces new bone formation in vivo with specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation and differentiation in vitro. J. Biol. Chem. 267, 2035220362.
  • Schreiber, E., Matthias, P., Muller, M.M. & Schaffner, W. (1989) Rapid detection of octamer binding proteins with ‘mini-extracts’, prepared from a small number of cells. Nucl. Acids Res. 17, 6419.
  • Schutte, M., Hruban, R.H., Hedrick, L., et al. (1996) DPC4 gene in various tumor types. Cancer Res. 56, 25272530.
  • Shi, Y. (2001) Structural insights on Smad function in TGF-β signaling. Bioessay 23, 223232.
  • Shi, Y., Wang, Y.-F., Jayaraman, L., Yang, H., Massague, J. & Pavletich, N. (1998) Crystal structure of a Smad1 MH1 domain bound to DNA: insights on DNA-binding in TGF-β signaling. Cell 94, 585594.
  • Storm, E.E., Huynh, T.V., Copeland, N.G., Jenkins, N.A., Kingsley, D.M. & Lee, S.J. (1994) Limb alterations in brachypodism mice due to mutations in a new member of the TGF β-superfamily. Nature 368, 639643.
  • Suzuki, A., Thies, R.S., Yamaji, N., et al. (1994) A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo. Proc. Natl. Acad. Sci. USA 91, 1025510259.
  • Tapscott, S.J. & Weintraub, H. (1990) MyoD and the regulation of myogenesis by helix-loop-helix proteins. J. Clin. Inv. 87, 11331138.
  • Thomas, J.T., Kilpatrick, M.W., Lin, K., et al. (1997) Disruption of human limb morphogenesis by a dominant negative mutation in CDMP1. Nat. Genet. 17, 5864.
  • Thomas, J.T., Lin, K., Nandedkar, M., Camargo, M., Cervenka, J. & Luyten, F.P. (1996) A human chondrodysplasia due to a mutation in a TGF-β superfamily member. Nat. Genet. 12, 315317.
  • Topper, J., DiChiara, M.R., Brown, J.D., et al. (1998) CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor β transcriptional responses in endothelial cells. Proc. Natl. Acad. Sci. USA 95, 95069511.
  • Tournay, O. & Benezra, R. (1996) Transcription of the dominant-negative helix-loop-helix protein Id1 is regulated by a protein complex containing the immediate-early response gene Egr-1. Mol. Cell. Biol. 16, 24182430.
  • Urist, M.R. (1965) Bone: formation by autoinduction. Science 150, 893899.
  • Vinals, F., Lopez-Rovira, T., Rosa, J.L. & Ventura, F. (2002) Inhibition of PI3K/p70 S6K and p38 MAPK cascades increases osteoblastic differentiation induced by BMP-2. FEBS Lett. 510, 99104.
  • Wieser, R., Wrana, J.L. & Massague, J. (1995) GS domain mutations that constitutively active TβR-I, the downstream signaling component in the TGF-β receptor complex. EMBO J. 14, 21992208.
  • Wozney, J.M. & Rosen, V. (1998) Bone morphogenetic protein and bone morphogenetic protein gene family in bone formation and repair. Clin. Orthop. 346, 2637.
  • Wozney, J.M., Rosen, V., Celeste, A.J., et al. (1988) Novel regulators of bone formation: molecular clones and activities. Science 242, 15281534.
  • Wrana, J. (2000) Regulation of Smad activity. Cell 100, 189192.
  • Wrana, J.L., Attisano, L., Weiser, R., Ventura, F. & Massague, J. (1994) Mechanism of activation of the TGF-β receptor. Nature 370, 341347.
  • Xu, X., Yin, Z., Hudson, J.B., Ferguson, E.L. & Frasch, M. (1998) Smad proteins act in combination with synergistic and antagonistic regulators to target DPP responses to the Drosophila mesoderm. Genes Dev. 12, 23542370.
  • Yamaguchi, A., Katagiri, T., Ikeda, T., et al. (1991) Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro. J. Cell Biol. 113, 681687.
  • Yamaguchi, K., Shirakabe, K., Shibuya, H., et al. (1995) Identification of a member of the MAPKKK family as a potential mediator of TGF-β signal transduction. Science 270, 20082011.
  • Yamamoto, N., Akiyama, S., Katagiri, T., Namiki, M., Kurokawa, T. & Suda, T. (1997) Smad1 and Smad5 act downstream of intracellular signalings of BMP-2 that inhibits myogenic differentiation and induces osteoblast differentiation in C2C12 myoblasts. Biochem. Biophys. Res. Commun. 238, 574580.
  • Yanai, T., Katagiri, T., Akiyama, S., et al. (2001) Expression of mouse osteocalcin transcripts, OG1 and OG2, is differently regulated in bone tissue and osteoblast cultures. J. Bone Miner. Metab. 19, 345351.