• Adams, R.H., Porras, A., Alonso, G., et al. (2000) Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development. Mol. Cell. 6, 109116.
  • Allen, M., Svensson, L., Roach, M., Hambor, J., McNeish, J. & Gabel, C.A. (2000) Deficiency of the stress kinase p38alpha results in embryonic lethality: characterization of the kinase dependence of stress responses of enzyme-deficient embryonic stem cells. J. Exp. Med. 191, 859870.
  • Arman, E., Haffner-Krausz, R., Chen, Y., Heath, J.K. & Lonai, P. (1998) Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development. Proc. Natl. Acad. Sci. USA 95, 50825087.
  • Bladt, F., Riethmacher, D., Isenmann, S., Aguzzi, A. & Birchmeier, C. (1995) Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud. Nature 376, 768771.
  • Giroux, S., Tremblay, M., Bernard, D., et al. (1999) Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta. Curr. Biol. 9, 369372.
  • Hindley, A. & Kolch, W. (2002) Extracellular signal regulated kinase (ERK)/mitogen activated protein kinase (MAPK)-independent functions of Raf kinases. J. Cell Sci. 115, 15751581.
  • Imaizumi, T., Araki, K., Miura, K., et al. (1999) Mutant mice lacking Crk-II caused by the gene trap insertional mutagenesis: Crk-II is not essential for embryonic development. Biochem. Biophys. Res. Commun. 266, 569574.
  • Itoh, M., Yoshida, Y., Nishida, K., Narimatsu, M., Hibi, M. & Hirano, T. (2000) Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation. Mol. Cell. Biol. 20, 36953704.
  • Mazzucchelli, C., Vantaggiato, C., Ciamei, A., et al. (2002) Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory. Neuron 34, 807820.
  • Mikula, M., Schreiber, M., Husak, Z., et al. (2001) Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene. EMBO J. 20, 19521962.
  • Mountford, P., Zevnik, B., Duwel, A., et al. (1994) Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression. Proc. Natl. Acad. Sci. USA 91, 43034307.
  • Mudgett, J.S., Ding, J., Guh-Siesel, L., et al. (2000) Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis. Proc. Natl. Acad. Sci. USA 97, 1045410459.
  • Nagy, A. & Rossant, J. (2000) Production and analysis of ES cell aggregation chimeras. In: Gene Targeting: a Practical Approach (ed. A.L.Joyner), pp. 177206. Oxford: Oxford University Press.
  • Niwa, H., Yamamura, K. & Miyazaki, J. (1991) Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 108, 193199.
  • Pages, G., Guerin, S., Grall, D., et al. (1999) Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice. Science 286, 13741377.
  • Qian, X., Esteban, L., Vass, W.C., et al. (2000) The Sos1 and Sos2 Ras-specific exchange factors: differences in placental expression and signaling properties. EMBO J. 19, 642654.
  • Rossant, J. & Cross, J.C. (2001) Placental development: lessons from mouse mutants. Nature Rev. Genet. 2, 538548.
  • Saxton, T.M., Cheng, A.M., Ong, S.H., et al. (2001) Gene dosage-dependent functions for phosphotyrosine-Grb2 signaling during mammalian tissue morphogenesis. Curr. Biol. 11, 662670.
  • Sibilia, M. & Wagner, E.F. (1995) Strain-dependent epithelial defects in mice lacking the EGF receptor. Science 269, 234238.
  • Sugiura, N., Suga, T., Ozeki, Y., Mamiya, G. & Takishima, K. (1997) The mouse extracellular signal-regulated kinase 2 gene. Gene structure and characterization of the promoter. J. Biol. Chem. 272, 2157521581.
  • Tamura, K., Sudo, T., Senftleben, U., Dadak, A.M., Johnson, R. & Karin, M. (2000) Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell 102, 221231.
  • Threadgill, D.W., Dlugosz, A.A., Hansen, L.A., et al. (1995) Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science 269, 230234.
  • Uehara, Y., Minowa, O., Mori, C., et al. (1995) Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor. Nature 373, 702705.
  • Xu, X., Weinstein, M., Li, C., et al. (1998) Fibroblast growth factor receptor 2 (FGFR2) -mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction. Development 125, 753765.