Menorrhagia in von Willebrand disease successfully treated with single daily dose tranexamic acid


Dr. Mayne Northern Ireland Haemophilia Comprehensive Care Centre, Department of Heamatology, Royal Group of Hospitals NHS Trust, Grosvenor Road, Belfast BT12 6BA, UK. Tel: (01232) 240503 ext 3519; fax: (01232) 325272.


Four cases of menorrhagia in von Willebrand disease were successfully treated with tranexamic acid given in a single daily dose of 4 g for the first 3–5 days of the menstrual cycle. The pathophysiology and pharmacokinetics are discussed. The apparent improved efficacy and acceptability of this new dosing regime have been highlighted.